DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and prdm15

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_009303772.1	Gene:	prdm15 / 566512	ZFINID:	ZDB-GENE-080618-4	Length:	1120	Species:	Danio rerio

Alignment Length:	1105	Identity:	217/1105 - (19%)
Similarity:	379/1105 - (34%)	Gaps:	325/1105 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DNPGKVPILLPNEE-----DTIDLDEPRMSQKIYELVGFTVSVDDKMPQTICSQCVDKINDFYEF 85
            :.||..|:..|..|     |.:....|..::            |..:||
Zfish   183 NKPGDSPMKAPPPENLPVPDQLLCQTPAPAE------------DPPVPQ---------------- 219

  Fly    86 REMCYATNKQTRNLLGLKQIEPARLIDLKRIVKEERPISGAVGKRGRKRKGEESWPKN--NNVKP 148
              :..|.::....::...|.|||:        |:.||         |:.|.::|.|..  |:.:.
Zfish   220 --VTEALSQNNTAIIAPIQPEPAK--------KQSRP---------RRTKTQKSVPSGAANSAQE 265

  Fly   149 QVKKESFVWHKKQKLQ---PSQITSLVSKREPEIKDEPAEQDTSLKGPPKKAGRKSICSVCGEKF 210
            ....||    .:|.|.   |....|::..:|..:..:|....||      :..|..|.|  |:..
Zfish   266 APVAES----NEQPLSTVAPDVPLSVLDVQEVMVSVDPLPLKTS------RLTRSPISS--GKPI 318

  Fly   211 LSKEL---ADEHKSLVHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLSKTPYKCPLCESSVANA 272
            |.|..   ..:||.:        |.|..||:...|.|::..|...|  ....:||..|:...:..
Zfish   319 LRKRTLRPGGDHKRV--------YQCCLCNKVFQNSSNLNRHIRSH--GDKCFKCDECDKMFSRK 373

  Fly   273 YAFTRHLR-EHTPPTPVQLLVLDRE----CPLCKKTFVTNFFYNTHRCAIRKR--KCGGCSRTLN 330
            .:..:|:. :|:...|      |.|    |..|:|:|........|.|....:  :|..|||..:
Zfish   374 ESLKQHISYKHSKNEP------DIEYRYKCSTCEKSFRVENALRFHNCRTDDKTFQCEICSRFFS 432

  Fly   331 TEAAYMRH----------APTCPKIYLNHSKHIMPQVVTNEAQMLI--KNEIEEELLGLPPATTV 383
            |.:...:|          ...|.|::  :.|.:|..   ::.:.::  ||...|||
Zfish   433 TNSNLSKHKKKHGEKLYACEICNKMF--YRKDVMQD---HQRRHVVGPKNLKREEL--------- 483

  Fly   384 PPDFVIDEGMQPVVVLERLSSPL------LRSSSGTDQLVAAKSKNSDRVSARNYLKRVDQLLKN 442
              :...:||.:  ...|..:.|:      .||:.....|.....|.:..:..|.:. ||| :|::
Zfish   484 --EVNGEEGSK--YRKEPSACPICGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFF-RVD-VLRD 542

  Fly   443 TINT-----LVSIKHEPEVHINDTGPPRGQAE--SDPEPERNE-EHPSFGDDIQAANDECQECQP 499
            .|:.     .:..:.|.|..|...|....:::  ||.|.|:|: ||..:         .|::||
Zfish   543 HIHVHFKDIALMDEQEREDFIKKIGISMEESDDSSDEEDEKNDPEHHKY---------SCKKCQ- 597

  Fly   500 ETESDKISVAACDDIPSVSVKQEPEYDGYEKQTGVKQEPLK----LKLKITKNH----------- 549
                  ::.|...|.....::...| .||......::..||    ..|.|.::|
Zfish   598 ------VTFAKGRDYLKHIMEMHKE-KGYNCTMCNRRFALKATYNAHLVIHRDHLPDPAVQKYIH 655

  Fly   550 -----GKLNSSLIDDLD---------------EAGQAFGRSSK-KKKKRKHKE-REKEASNETEN 592
                 |::.:| |.:||               :.|::|.|... |:..|.|.. |:...:...:.
Zfish   656 PCEMCGRIFNS-IGNLDRHKIIHTGVKSHCCEQCGKSFARKDMLKEHLRVHDNVRDFLCAECGKG 719

  Fly   593 CRTESQNQPAIKIKQEPVDYAPEATVMTTIPMTQFESSLNESERSEEVDEAMIQ--SQEDVKPNR 655
            .:|:...:..:|:.:...:|..:.   ......|..:.|...:|.....:.|.:  .:...:.|.
Zfish   720 MKTKHALRHHMKLHKGIKEYECKE---CNRKFAQKVNMLKHYKRHTGTKDFMCELCGKTFSERNT 781

  Fly   656 MELDRMMQISNVTSGVDMAEEAMALERAEEACPEDSLHKVKS-------VKSTARKSTGGAERKT 713
            ||..:::.....|....:.::....:...:...:.:..||::       .|.:.|.|.....|:.
Zfish   782 METHKLIHTVGKTFSCSVCDKKYVTQYMLQKHTQLTHEKVEAQSCHLCGTKVSTRASMNRHMRRK 846

  Fly   714 YSPPRTNTLPQIVAV------VSGESAF--NMISIKPEPRNLGYGDEEPEDQRETTEEINHNDMM 770
            :        |:||||      :|..|..  :.|||...|..|        |:...||:::.|
Zfish   847 H--------PEIVAVRLSEFDISEPSTVDASTISIAQPPLTL--------DKSSLTEKVSRN--- 892

  Fly   771 EEEKEYIGSLDLSDVSVKQERELDICEIDAVHRNGLEKSDEDDD---DGNEDSASSADEAEEAME 832
                           |.|:.:.|.       |...|..|||..|   ...|..|:..||...|::
Zfish   893 ---------------SKKRAKLLP-------HEPELSDSDEYSDFTSKNTEFPAAVGDETNSAVQ 935

  Fly   833 RDTEERIYREIELPPLELQNESSRKDLESERMDTEVSTALPAS-----------ETPSQ---TRD 883
            ...:..:..:...||:    .||..:|.:..: |.::|..||.           .|||.   |.|
Zfish   936 SIQQVVVLTDPSAPPV----SSSSVNLTNITV-TPITTPAPAQFSNLQPVAVSHLTPSDRPLTLD 995

  Fly   884 --VLGVEKSEASAFSLVIT---NICSQAV-------PQPSAACSNDIECSIGPSPSTTNEP---- 932
              :|.|.....|..:::..   ::.|:||       || |.|...::...:.|.|....:|
Zfish   996 SSILTVTFDTVSGSAMLHNRPPDLQSEAVGTVGATAPQ-SVAHFINLTTFVNPLPHQLEQPALTW 1059

  Fly   933 ------HSHTVENVQSPANDLQTSAQVAIAAQSQPDPCIVSQPAASSESQADTKDLPPAASQIQT 991
                  .:||. ::..|..|        .||...|.    .||          :.||....||||
Zfish  1060 RPVAADGAHTA-SIDDPQTD--------TAAPQGPS----DQP----------QTLPEQRHQIQT 1101

Fly 992 991
Zfish 1102 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	11/77 (14%)
		C2H2 Zn finger	203..224	CDD:275368	6/23 (26%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..282	CDD:275368	3/20 (15%)
		C2H2 Zn finger	297..314	CDD:275368	4/16 (25%)
prdm15	XP_009303772.1	COG5048	312..807	CDD:227381	105/553 (19%)
		zf-C2H2	334..356	CDD:278523	7/21 (33%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..413	CDD:275368	11/55 (20%)
		zf-C2H2	422..444	CDD:278523	6/21 (29%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	4/24 (17%)
		C2H2 Zn finger	500..520	CDD:275368	4/19 (21%)
		C2H2 Zn finger	527..547	CDD:275368	6/21 (29%)
		C2H2 Zn finger	621..644	CDD:275368	4/22 (18%)
		C2H2 Zn finger	657..677	CDD:275368	5/20 (25%)
		zf-H2C2_2	669..694	CDD:290200	4/24 (17%)
		C2H2 Zn finger	685..705	CDD:275368	5/19 (26%)
		C2H2 Zn finger	713..733	CDD:275368	2/19 (11%)
		C2H2 Zn finger	741..761	CDD:275368	2/22 (9%)
		C2H2 Zn finger	769..789	CDD:275368	3/19 (16%)
		C2H2 Zn finger	797..818	CDD:275368	0/20 (0%)
		C2H2 Zn finger	826..844	CDD:275370	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100