DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and tnc

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster

Alignment Length:	1411	Identity:	280/1411 - (19%)
Similarity:	486/1411 - (34%)	Gaps:	369/1411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NEEDTIDLDEPRMSQKIYELVGFTVSVDDK------------MPQTICSQCVDKIN--------- 80
            :|||:..:||....:|..|     .|.:||            :|..|.:..::|.:
  Fly  1271 SEEDSKPIDESEEDKKPVE-----ESAEDKKPVEDSEEKEKPLPTVIPASEIEKESKPEDEKKTE 1330

  Fly    81 -DFYEFREMCYAT---------NKQTRNLLGL-----------------KQIEPARLIDLKRIVK 118
             ||....|...||         .|:..:.|..                 |:.|.|::.|.:....
  Fly  1331 ADFAAPTEQPEATTPAQIADTAEKEVDDKLATTSAPVSGEDELKPADEKKRTETAQIPDAEIPAS 1395

  Fly   119 EERPISGA------VGKRGRK--RKGEESWPKNNNVKPQVKKESFVWHKKQK------LQPSQIT 169
            .:.|.|..      :.|:..:  .||.|: |:::.| |:|...:...::.::      :.|.:|
  Fly  1396 TDEPESSTELPTVDLDKKPEEDSTKGTEA-PESDKV-PEVPTSASTENEIEESDKFTTVAPPKI- 1457

  Fly   170 SLVSKREPEIKD-------EPAEQD-------TSLKGPP----------KKAGRKSICSVCGEKF 210
            |...:.||..::       ||.|.:       .:::|||          ||       .|..|..
  Fly  1458 SASDETEPTAEEDLVPATFEPIESEFEVSTKKPAVQGPPLPTLAPAQPEKK-------PVDAETS 1515

  Fly   211 LSKELADEHKSLVHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLSKTPY-------KCPLCESS 268
            ...:::.|..:.|..        .|..:|..:.::|.|     ..|.||.       |.|..|.:
  Fly  1516 TEADISTEPSAEVEK--------EASGETSESDNEIDA-----GASSTPVPVSADEDKTPSTEKT 1567

  Fly   269 VANAYAFTR-------HLREHTPPTPVQLLVLDRECPLCKKTFVTNFFYNTHRCAIRKRKCGGCS 326
            |.....||.       ....:.|..|..  :.:.|.|:...|...:             |..|..
  Fly  1568 VEADDKFTTVAPLAGDEEESNLPKLPQD--IFEEEAPVAVTTAAPS-------------KDDGEQ 1617

  Fly   327 RTLNTEAAYMRHAPTCPKIYLNHSKHIMPQVVTNEAQMLIKNEIEEELLGLPPATTVPPDFVIDE 391
            :.:..|          .|...:..|.|..:..|..:.   :||||.|   ...|||:.|.  .:|
  Fly  1618 KPVEVE----------EKPIEDGQKPIEDETSTPTSS---ENEIEPE---SDRATTIAPS--KEE 1664

  Fly   392 GMQPVVVLERLSSPLLRSSSGTDQLVAAKSKNSDRVSARNYLKRVDQLLKNTINTLVSIKHEPEV 456
            ..:|.........|   :...||...:.:||.:........:....:.:..:..|       |:.
  Fly  1665 PSEPSTGAPTKDEP---AEPSTDAPESDESKETPESEVPTTVAPAGEKIPTSSIT-------PDE 1719

  Fly   457 HINDTGPPRGQAESDPEPERNEEHP-----SFGDDIQAAND----ECQECQPET------ESDKI 506
            ....|..|..:.:.|.|.|.:.|.|     |..:|..::.|    |..|.:|||      |.|.:
  Fly  1720 EPTATSAPVAKPDEDVEKETSTEIPTDAPASSEEDENSSTDQIPSEVPEKKPETPAQTPEEGDIV 1784

  Fly   507 SVAAC----DDIPSVSVKQE---PEYDGYEKQTGVKQ-------------EPLKLKLKITKNHGK 551
            ...|.    |::|.|....|   .|......:||:||             ||
  Fly  1785 GATAAPTTSDEVPPVQRLPEEVLAEIPQPSTETGIKQQDETTAAPSIDRKEP------------- 1836

  Fly   552 LNSSLIDDLDEAGQAFGRSSKKKKK---------------------RKHKEREKEASNE------ 589
                .:.::||........|:|.:|                     .|.|..|::.|.|
  Fly  1837 ----YVTEIDEEATTVAPISEKDEKPTEEEKPVEQKPTGEEPSEEEEKEKPIEQDVSTEGPVSTE 1897

  Fly   590 -TENCRTESQNQ--PAI--KIKQEPVDYAPEATV---MTTIPMTQFESSLNESERSEEVDEAMIQ 646
             :|...|||..:  |:.  ::.::|.|..|.:|.   :.|||  :..:.|...:..:...||.:.
  Fly  1898 ASEAGSTESSEEVKPSTEGEVAEKPEDKQPSSTAQAPVETIP--EISTELPAQDGDKPTSEAPVD 1960

  Fly   647 SQEDVKPNRMELDRMMQISNVTSGVDMAEEAMALERAEEACPEDSLHKVKSVKSTARKSTGGAER 711
            |.||......|     :|.:| ||.:: |.......:.:|..||.|   |:...:...||.....
  Fly  1961 SDEDTSAPSDE-----KIPSV-SGEEV-EGPEVTTASPQAAEEDEL---KTPAESEPSSTDKVPE 2015

  Fly   712 KTYSPPRTNT----LPQIVAVVSGESAFNMISIKPEPRNLGYGDEEPEDQRETTEEINHNDMMEE 772
            ..|..|...|    .|:.|..||..:......:       ..||.|.::|..|...       ||
  Fly  2016 TEYQKPEDETKADETPESVTQVSDVATSTSAPV-------AGGDIEKDEQATTASP-------EE 2066

  Fly   773 EKEYIGSL-DLSDVSVKQERE-LDICEIDAVHRNGLEKSDEDDDDGNEDSASSA-----DEAEEA 830
            |:|...:: ..:::....|:| :|..|::    :|.:.:..:.|....|..:.|     |||..|
  Fly  2067 EEEIKPTIAPAAEIPQPSEKEPVDEQEVE----SGTKATPAESDGQPIDEIAPATSGPIDEASTA 2127

  Fly   831 MERDTEERIYREIELPPL---ELQNESSRKDLESER----MDTEVSTALPAS-ETPSQTRDVLGV 887
            .....|.........|.:   |:::.::.:.:..|:    ...|..|::..| ::|:...|
  Fly  2128 APTKEESTTVASAASPAVHDDEIKDVTTTQPVADEKEVAAPQDETKTSIDVSTDSPTAQDD---- 2188

  Fly   888 EKSEASAFSLVITNICSQAVPQPSAACSNDIECSIGPSP------------STTNEPHSHTVENV 940
            ||.:.:...:..|.:.|......:.:.:..:|.   |||            |.|..|  ||.:..
  Fly  2189 EKQDKTEAPVAPTTVSSPTADSAADSSTPTVEV---PSPVEIDTKPMDDIMSQTIAP--HTADGA 2248

  Fly   941 QSPANDLQTSAQVAIAAQSQPDPCIVSQP-----AASSESQADTKDLPPAASQIQTFNTESLPIH 1000
            .|.:.:.:..|.|.::.|......:...|     ..|||:..|..::|..|:.:   :...:|..
  Fly  2249 ASTSTEDEDQAPVTVSPQDAEKTPVSPAPQDSDKTPSSEAPQDADEIPATATPL---DDNKIPAT 2310

  Fly  1001 VHSETEDNSIENDASYLESRAQVDCQSAGTEN-PSVVLE-QNESLPSGSCVSPI-----PENPSP 1058
            |..:|:|......|...|.:.|........|. ||.... .:|.:|:.  |||:     |.:..|
  Fly  2311 VAPQTDDGVPATAAPLDEDKIQTTAAPLDEEKIPSTAAPLDDEKIPAP--VSPVVFDVEPSSEKP 2373

  Fly  1059 GNS---------PPQHDESESLDKPEMAA---GSAYCLATVSLDAPKDTEALALPPCDAAIIDSN 1111
            ..|         ||.||...|.|:|...|   ......||.| ::|. |||..:|...|..::..
  Fly  2374 AVSEYDGEESTEPPVHDVETSTDEPTSDAKLKPPTSAPATPS-ESPA-TEAEIVPETAAPELEKE 2436

  Fly  1112 YTSDEEQQNVLNHELSEQ--QLAIMEHRQLLVHEEQPALLEVIPPGLSSRPIEETE--NRINEQQ 1172
            ......:|..|..|..|:  :...:|........|||.|.:..|...:.:|..|.|  ::..||.
  Fly  2437 VPEKATEQPELEKETPEKATEQPELEKETPEKATEQPELEKETPEKATEQPELEKEVTDKATEQP 2501

  Fly  1173 QDLEQGEERPPRFQAN------DDSNINEIAENNNNANIERELQDD 1212
            :.:::.....|..:.:      |:.::....|:.:..:..:|.::|
  Fly  2502 ESVDEKTTPEPVVKPSLDSTEEDEESVESEEESADKKDKNKETEED 2547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	19/92 (21%)
		C2H2 Zn finger	203..224	CDD:275368	3/20 (15%)
		C2H2 Zn finger	233..253	CDD:275368	4/19 (21%)
		C2H2 Zn finger	262..282	CDD:275368	5/26 (19%)
		C2H2 Zn finger	297..314	CDD:275368	2/16 (13%)
tnc	NP_001247300.1	VWC	235..296	CDD:214564
		PHA02664	<433..595	CDD:177447
		Ehrlichia_rpt	529..1065	CDD:118064
		DUF863	<1684..>1788	CDD:283539	22/110 (20%)
		VWC	2762..>2805	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900