DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and Cp190

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	1251	Identity:	257/1251 - (20%)
Similarity:	426/1251 - (34%)	Gaps:	338/1251 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NEEDTIDL-----DEPRMSQKIYELV------GFTV------SVDDK--MPQTICSQCVDKINDF 82
            |:.|..||     |..::  |::.||      .|.|      .|||.  ||....:..|..|.:|
  Fly    25 NKTDYCDLTLQFRDNSQL--KVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVVPIVNF 87

  Fly    83 -----YEFREMCYA----TNKQTRNLLGLKQIEPARLIDLKRIVKEERPISGAVGKRGRKRK--G 136
                 .||....|.    |.|:....:.||.:|..|. .::.:.:::||.|    .:|.:|:  |
  Fly    88 MYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEAHRR-TMENVNRQQRPPS----PKGIRRRTVG 147

  Fly   137 EES-----------WPKNNNVKPQVKKESFVWHKKQKLQPSQITSLVSKREP-----EIKDEPA- 184
            :.|           .|::.||...:.:.:...........|: ||..|.|.|     .:|.||.
  Fly   148 QPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSR-TSGGSNRSPYGDSSNVKQEPTS 211

  Fly   185 --EQ------------DTSLKGPP-KKAGRKSICSVCGEKFLSKELADEHKSLVHVPSIPRYICN 234
              ||            .|||..|| ||...:.:.....::.:.|::|.|:..     :.|.|...
  Fly   212 PFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGD-----NDPEYDGG 271

  Fly   235 AC-NQTHHNQSDIRAHQLWHKLSKTPYKCPLCESSVANAYAFTRHLREHTPPTPVQLLVLDRECP 298
            .. :..|....|.         ...|   |...:|...:...|:...||...|    ::|.::.|
  Fly   272 MLYDDVHAGDDDD---------DDMP---PQPSTSKQQSPQGTQTQLEHGSTT----IILKQDSP 320

  Fly   299 LCKKTFVTNFFYNTHRCAIRKRKCGGCSRTLNTEAAYMRHAPTCPKIYLNHSKHI------MPQV 357
            ....|.:.....|..                                 |||:|.|      .|.:
  Fly   321 SQTPTIIVKDSSNAK---------------------------------LNHTKIIAEVLRQYPHI 352

  Fly   358 VTNEAQMLIKNEIEEELLGLP-----PATTVPP----------------DFVIDEGMQPVVVLER 401
            |.....  ||.:|.......|     |||..||                .|..|:....:...::
  Fly   353 VKGHKN--IKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQK 415

  Fly   402 LSSPLLRSSSGTDQLVA--AKSKNSDRVSARNYLKRVDQLLKNTINTLVSIKHEPEVHINDTGP- 463
            .:|.  :..|||.|...  ....|....:|....:|:|   ..|::.|::...|     |.|||
  Fly   416 AASS--QQKSGTSQTTGNQGTGANPPANTAAAQKRRID---SKTMHALIAQGAE-----NTTGPW 470

  Fly   464 ------PRGQAESDPEPERNEEH--PSFGDDIQAANDECQEC----------------QPETESD 504
                  ..|:..|.|.......|  .:..:.|..|  .|:.|                :.:|:|.
  Fly   471 LCLRCGVNGRPISIPSYRGFRRHLINTHKETIDPA--LCEHCGWRSVNNRELHFHMYMEHQTKSL 533

  Fly   505 KISVAACDDIPSVSVKQEPEYDGY--------EKQ-----TGVKQEPLKLKLKITKNHGK--LNS 554
            ..:.|.| .:.:.|.:.:.|.:.:        .||     ..|.::.|:|...:...|.:  |..
  Fly   534 LYTFAEC-ALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQALED 597

  Fly   555 SLIDDLDEAGQAFGRSSKKKKKRKHKEREKEASNETENCRTESQNQPAIKIKQEPVDYAPEATVM 619
            .:||:.||  :..|...::::....:|:|.|   :|...|..|             |.:..||..
  Fly   598 GIIDETDE--EFLGSQDEEEEAEGDEEQEPE---QTGKVRILS-------------DISLPATSA 644

  Fly   620 TTIPMTQFESSLNESERSEEVDEAMIQSQEDVK-----PNRMEL------DRMMQISNVTSGVDM 673
            .|:...|     .|..:.|:|:    |.|::||     .|.:||      :.:.|::...:|...
  Fly   645 ITVQQAQ-----QEQLQEEDVE----QVQQEVKFVGADGNEVELTDEQRKEILSQLNQQQAGATA 700

  Fly   674 AEEAMALERAEEACPEDSLHKVKSVKSTARKSTGGAER-----KTYSPPRTNTLPQIVAVVSGES 733
            ....|.|.       |.....||  :.|..||..|.|.     :.||        ::.|..|.||
  Fly   701 GGVVMVLS-------EPEAEHVK--QETDEKSLAGTEEEYDDSQIYS--------ELGAADSVES 748

  Fly   734 AFNMISIKPEPRNLGYGDEEPEDQRETTEEINHNDMMEEEKEYIGSLDLSDVSVKQERELDICEI 798
            |         .:|:....:|..|..|..|.:......:..||........|:|.|. :||
  Fly   749 A---------KKNIADESKESIDNLEWAENLIAESEEQSNKEPKSDKPRDDISEKL-KEL----- 798

  Fly   799 DAVHRNGLEKSDEDDDDGNEDSASSADEAEEAMERDTEERIYREIELPPLELQN-----ESSRKD 858
                 .|....||:||| .:|..::|:.|.|...:|.|..::.|.:...|.||:     |.:.::
  Fly   799 -----TGDWTEDENDDD-VDDKPATAELASELANKDPEPTVHEEEDDIDLALQSLHKGPEEATEE 857

  Fly   859 LESERMDTEVSTALPASETPSQTRDVLGVEKSEASAFSLVITNICSQAVPQ--PSAACSNDIECS 921
            ..||...|....|:.|....:...:.:.|: |||:      ....|:|..|  ..|...||.|..
  Fly   858 KASEESVTSADDAVDAVPNINSQPEKMDVD-SEAA------DEKASKAEVQIKKEAELENDQEEF 915

  Fly   922 I-GPSPSTTNEPHSHTVENVQSPANDLQTSAQVAIAAQSQPDPCIVSQPAASSESQADTKDLPPA 985
            | ..||.    |||.:|..::......:....|.:.|.:.... ::.:..|.:|.....||:
  Fly   916 IKEDSPI----PHSDSVAELREAVTASEGEDDVHLEADNIRKE-LLDELIAEAEKPDQEKDI--- 972

  Fly   986 ASQIQTFNTESLPIHVHSETEDNSIENDASYLESRAQVDCQSAGTENPSV--VLEQNESLPSGSC 1048
            ....:...||:|         |.|: .|...|....||..:....:.|:.  ..|.||...:..
  Fly   973 VQSEENATTEAL---------DRSV-TDEDDLVPPTQVSTEQMEIDEPAAEKAAENNEDTRTAD- 1026

  Fly  1049 VSPIPENPSPGNSPPQHDESESLDKPEMAAGSAYCLATVSLDAPKDTEALALPPCDAAIIDSNYT 1113
                 |..:..:.|.|..:..:.:||.:.:..|.       |.....||.::....:.|.:....
  Fly  1027 -----EKEAVEDKPNQTQDVTTAEKPTLESAKAG-------DEATSGEAASVDKVKSLISEWGDD 1079

  Fly  1114 SDEEQQNVLNHELSEQ 1129
            .::|.:|.::....|:
  Fly  1080 DEDEDENGVSAAAKEE 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	23/89 (26%)
		C2H2 Zn finger	203..224	CDD:275368	3/20 (15%)
		C2H2 Zn finger	233..253	CDD:275368	2/20 (10%)
		C2H2 Zn finger	262..282	CDD:275368	3/19 (16%)
		C2H2 Zn finger	297..314	CDD:275368	3/16 (19%)
Cp190	NP_524359.2	BTB	20..122	CDD:279045	26/98 (27%)
		BTB	31..127	CDD:197585	25/98 (26%)
		C2H2 Zn finger	540..568	CDD:275371	4/28 (14%)
		C2H2 Zn finger	569..586	CDD:275371	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900