DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and CG43340

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001246184.1	Gene:	CG43340 / 35698	FlyBaseID:	FBgn0263077	Length:	3213	Species:	Drosophila melanogaster

Alignment Length:	1403	Identity:	262/1403 - (18%)
Similarity:	459/1403 - (32%)	Gaps:	460/1403 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VPILLPNEEDTIDLDEPRMSQKIYELVGFTVSVDDKMPQTICSQCVDKINDFYEFREMCYATNKQ 95
            |.::...|....|..||..:..|.|::.|..|..| :|:|                        .
  Fly  1322 VDLIATTEAVNADHSEPGEAGLISEVLQFHSSGGD-LPET------------------------D 1361

  Fly    96 TRNLLGLKQIEPARLIDLKRIVKEERPISGAVGKRGRKRKGEESWPKNNNVKPQVKKESFVWHKK 160
            :|.:..|....||.:|::.       |:..|
  Fly  1362 SRAIEPLPLAPPAEVIEVV-------PLGSA---------------------------------- 1385

  Fly   161 QKLQPSQITSLVSKRE---PEIKDEPAEQDTSLKGPPKKAGRKSICSVCGEKFLSKELADEHKSL 222
            :.|.||:.|.:||...   || |.||.|..|.::       .:.:.|....:.:.....|.|::
  Fly  1386 ELLSPSEPTEVVSPSAIALPE-KPEPMENATEIE-------IEEMVSPTSVEIVPTTTEDLHQA- 1441

  Fly   223 VHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLSKTPYKCPLCESSVANAYAFTRHLREHTP--- 284
            ..|....|.: :|..:....:....|      :.|:|...|: |..      .::|..:.||
  Fly  1442 ESVVETARPV-SAVEEVKPIEDSTAA------IDKSPQISPI-EGE------HSQHSEKETPESV 1492

  Fly   285 ------PTPVQLLVLDRECPLCKKTFVTNFFYNTHRCAIRKRKCGGCSRTLNTEAAYMRHAPTCP 343
                  |....::....|......|.||.                  |...:||      .|..|
  Fly  1493 EVGLDSPNVADVITTSVEVIPTSTTAVTT------------------SDGASTE------MPEPP 1533

  Fly   344 KIYLNHSKHIMPQVVTNEAQMLIKNEIEEELLGLPPATTVPPDFVIDEGMQPVVVLERLSSPLLR 408
            |||...:.....::..||.         .|.|.:...||:|.:.|..:|.             |.
  Fly  1534 KIYCETAPPAAEEIEQNET---------VETLSVSADTTLPEEIVSQDGN-------------LE 1576

  Fly   409 SSSGTDQLVAAKSKNSDRVSARNYLK--------RVDQLLKNTINTLVSIK-------------- 451
            :|..|..:......|.:.:.::..::        :.|:.|...|...|::.
  Fly  1577 ASEQTASIDVTFQANLNNMESKGCVEVAVDVRESKEDETLMEPIAVDVAVPVEVVPQCAGVELGV 1641

  Fly   452 HEPEVHINDT-------GPPRGQAE-SDPEPERNEEH---PSFGDDIQAAND------------- 492
            .|||.....|       .||...:| .|.||....|.   .||..|.|.::|
  Fly  1642 SEPEEATPATNNLTSGENPPEEVSELVDVEPRNPHEEIHTDSFEKDSQKSSDAVALHEDNTKSEE 1706

  Fly   493 ---------------------ECQECQPETESDKISVAACDDI---------------------- 514
                                 ...|..|:|::..|...|..||
  Fly  1707 KVDPPQVAEEVAPDIITLDPPSLVELSPDTQAMAIGNIAPFDIILEPESIVIEQPVPVVKPETIV 1771

  Fly   515 ---------------PSVSVKQEPEYDGYEKQT----GVKQEPLKLKLKITKNHGKLNSSLIDDL 560
                           ||||.:.:.:.:..::|.    .|:::.||:.:   ...|::.|  :|.:
  Fly  1772 VESDPEAIDHTALLEPSVSAEVQDKVESAQQQVSENKSVEEDSLKVSI---GERGEIIS--MDPI 1831

  Fly   561 DEAGQAFGRSSKKKKKRKHKEREKEASNETENCRTESQNQPAIKIKQEPVDYAPEATVMTTIPMT 625
            ..|...          .:...|.::....||:...|.....:|....|||..|...|:..:.|..
  Fly  1832 TPADAV----------SEQNFRVEDPITSTESTAVEVIASESINTVVEPVSVAQSPTIEDSTPEE 1886

  Fly   626 QFESSLNESERSEEVDEAMIQSQEDVKPNRMELDRMMQISNV-TSGVDMAE-EAMALERA--EEA 686
            ..:.|...|..:|....|.||..:.::|..:||...::.|:: .|..|.|: |:.::::|  .:.
  Fly  1887 VTQCSAVNSTDTEVASAAPIQVDQKIQPVHVELVSQIEASDLQESPKDTAQVESDSVDQAILTQV 1951

  Fly   687 CPEDSLHKVKSVKSTARKSTGGAERKTYSPPRTNTLPQIVAVVSGESAFNMISIKPEPRNLGYGD 751
            ...||:  |....|..::|    |.....||              .||.|::.:.|...:....:
  Fly  1952 SETDSI--VVEPSSPVKQS----EDSQGEPP--------------GSAQNVLDVGPVEMDQSAPE 1996

  Fly   752 EEPED-----------QRETTEEINH-----NDMMEEEKEYIGSLDLSDVSVKQERELDICEIDA 800
            |.||.           :.|..|.|..     :|.:|...:.:|:.||    |.:...:|....:|
  Fly  1997 EVPETDPVAVEPSVPVEEEVIEVIQPAPKEISDSVERTLDSLGNTDL----VAEAESVDTPAENA 2057

  Fly   801 ---VHRNGLEKS--------DEDDDDGNEDSASSADEAEEAMERDTEERIYRE------------ 842
               :..:.|||.        ||......|............::.:..|.:..:
  Fly  2058 GPEIGTSELEKELLVVSTTIDEQPSAVLEPLVLICQAESTNLDHELPENLVPQGQSVPASLPTNL 2122

  Fly   843 -IELPPLELQNESSRK-DLESERMDTEV--------STALPASET-------------PSQTRDV 884
             |:..|.:|:.:.|.: .|::|.:|.|:        ||...:.||             |.:..::
  Fly  2123 TIQTQPTDLETQPSMELILQTETVDAEMVKPVDMGDSTVDKSQETGEMVLKLESSKWEPLEATEL 2187

  Fly   885 LGVEKSEASAFSLVITNICSQAVPQ-PSAACSNDIECSIGPSPSTTNEPHS--HTVENVQSPAND 946
            :.:|.|..:..:...:.|.:..||| .|...|...|..|.|.|   .|||:  :.:....|.:.|
  Fly  2188 VTMEPSSETESTCADSKIYANLVPQLDSVPLSVPTELRIQPEP---EEPHAFENPIPETVSSSED 2249

  Fly   947 LQTSAQVAIAAQSQPDPCIVSQPAASSESQADTKDLP--PAASQIQTFNTESLPIHVHSETEDNS 1009
            |...|||.|    |.||..:             ::||  |....:...|.|..|:.:.|::.|.:
  Fly  2250 LLEPAQVLI----QEDPVAL-------------ENLPGVPIVPDVHAHNFEPSPVEITSQSADTN 2297

  Fly  1010 IENDASYLESRAQVDCQSAGTENPSVVLEQNESLPSGSCVSPIPENPSPGNSPPQHDESESLDKP 1074
                                    ::|..:.|::     :.|..|.|||
  Fly  2298 ------------------------AIVPVEVETI-----MKPETEAPSP---------------- 2317

  Fly  1075 EMAAGSAYCLATVSLDAPKDTEALALPPCDAAIIDSNYTSDEEQQNVLNHELSEQQLAIMEHRQL 1139
             ||..|...|..|:||..:...|....|.: .:.::.:.::|.:......:....::::.
  Fly  2318 -MAVESTPDLEAVALDTKESVPAAQAIPVE-VVPETEHLTEETKNETAKMDAEPARISVE----- 2375

  Fly  1140 LVHEEQP-ALLEVIP--PGLSSRPIEETENRI-------NEQQQDLEQGEERPPRF----QANDD 1190
            :|.|||| :|...||  ...||.|:|...:.:       :.:|::....||  |.|    ..|||
  Fly  2376 IVQEEQPLSLGNKIPVENETSSAPVEAPFDTVSIPASVDSVEQKESNASEE--PHFGEDILKNDD 2438

  Fly  1191 SNINEIAENNN------NANIERELQDDAL-GAQENVN 1221
            :.:..:..|.:      .|:|::||:|.|. |..:|.:
  Fly  2439 AILETVTANADLSSDAQLASIDQELKDPATEGIHKNTS 2476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	13/67 (19%)
		C2H2 Zn finger	203..224	CDD:275368	3/20 (15%)
		C2H2 Zn finger	233..253	CDD:275368	2/19 (11%)
		C2H2 Zn finger	262..282	CDD:275368	3/19 (16%)
		C2H2 Zn finger	297..314	CDD:275368	3/16 (19%)
CG43340	NP_001246184.1	FYVE_BSN_PCLO	63..119	CDD:277290
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900