DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1647 and REPIN1

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001374966.1	Gene:	REPIN1 / 29803	HGNCID:	17922	Length:	626	Species:	Homo sapiens

Alignment Length:	351	Identity:	71/351 - (20%)
Similarity:	106/351 - (30%)	Gaps:	128/351 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 CYATNKQTRNLLGLKQIEPARLIDLKRIVKEERPIS-GAVGKR----------GRKRKGEESWP- 141
            |....|:.|:       :| .||..:|:...|||.. ...|||          .|...||:.:|
Human   297 CACCGKRFRH-------KP-NLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPC 353

  Fly   142 ----KNNNVKPQVKKESFVWHKKQK----------------------LQPSQITSLVSKREPEIK 180
                :....||.:...|.: ||:.:                      .:|:....|...:||...
Human   354 KECGRRFRHKPNLLSHSKI-HKRSEGSAQAAPGPGSPQLPAGPQESAAEPTPAVPLKPAQEPPPG 417

  Fly   181 DEPAEQDTSLKGPP-------------------------------------KKAGRKS------- 201
            ..|......::.||                                     |..|:|:
Human   418 APPEHPQDPIEAPPSLYSCDDCGRSFRLERFLRAHQRQHTGERPFTCAECGKNFGKKTHLVAHSR 482

  Fly   202 --------ICSVCGEKF-LSKELADEHKSLVHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLSK 257
                    .|..||.:| ....||...:.  |.|..| ::|..|.:...::..:.||:..|...|
Human   483 VHSGERPFACEECGRRFSQGSHLAAHRRD--HAPDRP-FVCPDCGKAFRHKPYLAAHRRIHTGEK 544

  Fly   258 TPYKCPLCESSVANAYAFTRHLREHTPPTPVQLLVLDRECPLCKKTFVTNFFYNTHR-------- 314
             ||.||.|..:.:.......|.|.||...|.       .||.|.::|.......|||
Human   545 -PYVCPDCGKAFSQKSNLVSHRRIHTGERPY-------ACPDCDRSFSQKSNLITHRKSHIRDGA 601

  Fly   315 --CAIRKRKCGGCSRTLNTEAAYMRH 338
              |||       |.:|.:.|...:.|
Human   602 FCCAI-------CGQTFDDEERLLAH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	3/9 (33%)
		C2H2 Zn finger	203..224	CDD:275368	6/21 (29%)
		C2H2 Zn finger	233..253	CDD:275368	4/19 (21%)
		C2H2 Zn finger	262..282	CDD:275368	5/19 (26%)
		C2H2 Zn finger	297..314	CDD:275368	5/16 (31%)
REPIN1	NP_001374966.1	C2H2 Zn finger	118..138	CDD:275368
		C2H2 Zn finger	146..166	CDD:275368
		C2H2 Zn finger	177..197	CDD:275368
		COG5048	<197..371	CDD:227381	19/81 (23%)
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	238..258	CDD:275368
		COG5048	292..599	CDD:227381	64/321 (20%)
		C2H2 Zn finger	297..317	CDD:275368	7/27 (26%)
		C2H2 Zn finger	325..345	CDD:275368	4/19 (21%)
		C2H2 Zn finger	353..373	CDD:275368	3/20 (15%)
		C2H2 Zn finger	436..456	CDD:275368	0/19 (0%)
		C2H2 Zn finger	464..484	CDD:275368	3/19 (16%)
		C2H2 Zn finger	492..512	CDD:275368	6/21 (29%)
		C2H2 Zn finger	520..540	CDD:275368	4/19 (21%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100