DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1647 and Leo1

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001034611.1	Gene:	Leo1 / 235497	MGIID:	2685031	Length:	667	Species:	Mus musculus

Alignment Length:	624	Identity:	115/624 - (18%)
Similarity:	206/624 - (33%)	Gaps:	188/624 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 IDDLDEAGQAFGRSSKKKKKRKHKEREKEASNETENCRTES--------------QNQPAIK--- 604
            ::||      ||..::.:.:||..|.|.::.::.:|..:.|              ..||:.|
Mouse     4 MEDL------FGSEAESEAERKDSESESDSDSDQDNGASGSNASGSESDQDDRGDSGQPSNKELF 62

  Fly   605 ---IKQEPVDYAPEATVMTTIPMTQFESSLNESERSEEVDEAMIQS-QEDVKPNRMELDRMMQIS 665
               .::|...:              ...|.|.||||:...||..:| .||.:|
Mouse    63 GDDSEEEGASH--------------HSGSDNHSERSDNRSEASERSDHEDNEP------------ 101

  Fly   666 NVTSGVDMAEEAMALERAEEACPEDSLHKVKSVKSTARKSTGGAERKTYSPPRTNTLPQIVAVVS 730
               |..|.       ....||..:|.....:|.:.:......|:|:......:.:
Mouse   102 ---SDEDQ-------HSGSEAHNDDDDEGHRSDEGSRHSEAEGSEKAQSDDEKWD---------- 146

  Fly   731 GESAFNMISIKPEPRNLGYGDEEPEDQRETTEEINHNDMMEEEKEYIGSLDLSDVSVKQERELDI 795
            ||..    |.:.:...|...|:|..:|....:::.::|..||:.:.....|.:.:|....::|
Mouse   147 GEDK----SDQSDDEKLQNSDDEDREQGSDEDKLQNSDDDEEKMQNTDDEDRAQISDDDRQQL-- 205

  Fly   796 CEIDAVHRNGLEKSDEDDD-----DGNEDSASSADE------AEEAMERDTEERIYREIELPPLE 849
                    :..||.:.||:     |.:|:..:|.||      .||.|:...:||        |..
Mouse   206 --------SEEEKGNSDDEHPVASDNDEEKQNSDDEDQPQVSDEEKMQNSDDER--------PQV 254

  Fly   850 LQNESSRKDLESERMDTEVSTALPASETPSQTRDVLGVEKSEASAFSLVITNICSQAVPQPSAAC 914
            ...:..|.|.|.|:.....|.....||.     :||.:::              ..|:|..|.|
Mouse   255 SDEDGRRSDGEEEQDQKSESARGSDSED-----EVLRLKR--------------KNAIPSDSEA- 299

  Fly   915 SNDIECSIGPSPSTTNEPHSHT-VENVQSPANDLQTSAQVAIAAQSQPDPCIVSQPAASSESQAD 978
                       .|.|..|..:. ..::...|:|:                          .|.:|
Mouse   300 -----------DSDTEVPKDNNGTMDLFGGADDI--------------------------SSGSD 327

  Fly   979 TKDLPPAASQIQTFNTESLPIHVHSETEDNSIENDASYLESRAQVDCQSAGTE--NPSVVLEQNE 1041
            .:|.||...|         |:..:...:|...|....  |:|.:|:.....|:  |....::
Mouse   328 GEDKPPTPGQ---------PVDENGLPQDQQEEEPIP--ETRIEVEIPKVNTDLGNDLYFVK--- 378

  Fly  1042 SLPSGSCVSPIPENPSPGNSPPQHDESESLDKPEMAAGSAYCLATVSLDAPKDTEALALPPCDAA 1106
             ||:...|.|.|.:|.  ....:.::.|.||:............|:.....:|.|...:...:|.
Mouse   379 -LPNFLSVEPRPFDPQ--YYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNAR 440

  Fly  1107 IIDSNYTSDEEQQNVLNHELSEQQLAIM--EHRQLLVHE 1143
            |:.   .||......|.:|:.:...|.:  :|..|.:.:
Mouse   441 IVK---WSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQ 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	297..314	CDD:275368
Leo1	NP_001034611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..362		91/499 (18%)
		PHA02664	<61..209	CDD:177447	34/207 (16%)
		Leo1	375..533	CDD:281933	21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900