DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and Rp1

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_035413.1	Gene:	Rp1 / 19888	MGIID:	1341105	Length:	2095	Species:	Mus musculus

Alignment Length:	1441	Identity:	255/1441 - (17%)
Similarity:	480/1441 - (33%)	Gaps:	438/1441 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DKINDFYEFREMCYATNKQTRNLLGLKQIEPARLIDLKRIVKEERPISGAVGKRGRKRKGEESWP 141
            :|:|.|         .|.:|:.||..::..|.:::..:|:.|:|      :|:..:.....:|..
Mouse   743 NKLNTF---------QNPKTQKLLAKRKSRPRKIVSTERLRKQE------IGQEDKILLHSDSKL 792

  Fly   142 KNNNVKPQ--------VKKESFVWHKKQKLQPSQITSL------VSKRE--PEIKD--------- 181
            ..::::.|        ::::..|.|:    .|.|:..:      ::|:.  |::.|
Mouse   793 CESHLEKQSLFHVFNILEEDQKVLHR----PPFQVEKVARNLKGMAKKSLVPKVNDLHIMLRNQK 853

  Fly   182 -----------EPAEQDTSLKGPPKKAGRK-----SICSVCGEKFLSKEL--ADEHKSLVHVPSI 228
                       |.:||..:.:..|..:.:|     .|....|:.::.:.|  .:.:....|..|.
Mouse   854 KQMGVKLKSGAEVSEQHVTTRADPLASLKKPDFPEGIPHHSGKSYVKRWLQNINSYPDFEHRKSG 918

  Fly   229 PRYIC-NACNQTHHNQSDIRAHQLWHKLSK----------------------------------- 257
            |  :| |..:..::|::....:.|....||
Mouse   919 P--LCQNRSDVVNYNRNGFLGNNLHTTSSKGNGFLMESNKSKTKNDNWSGNTNQETGKSLVAKDN 981

  Fly   258 ----TPYKCPLCESSVANAYAFTRH----LREHT--PPTPVQLLVLDRECPLCKKTFVTNFFYNT 312
                ..:.|.....|:.::|..:.|    |.:.|  .|:....|.:::..|..|..:....|...
Mouse   982 GEELNKHHCESQNGSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPEVKLVYQEMNFATK 1046

  Fly   313 HR---CAIRKRKCGGCSRTLNTEAAYMRHAPTCPKIYLNHSKH--------------IMPQVVTN 360
            .:   .||:....|.........|..:||...   ...|:.||              :.|.|:.|
Mouse  1047 RQSIEVAIQVDTMGENVLKDYLPALLLRHLEA---FVPNNQKHQNGISQIPGSLAEVVFPSVIDN 1108

  Fly   361 E------AQMLIKN---------EIEEELLGLPPATTVPPDFVIDEGMQPVVVLERL-------- 402
            .      |.:|:.|         :.:...:...|:.|.    .:.|.::.|.:.|..
Mouse  1109 SSTNLLLAWLLVLNLKRTMNSFCQSDAHKMTNRPSETA----ALLEVLKHVAITEEADDLKAAVA 1169

  Fly   403 ----SSPLLRSSSGTDQ-----------LVAAKSKNSDRVSARNYLKRVDQLLKNTINTLV--SI 450
                |:.....|||.:|           |.:....|.:..:.:..|.....::.:..:.:|  |.
Mouse  1170 NLMESTKTCSGSSGREQDMLPVNCTASSLHSVDECNENGSAQKTLLDEGYSVMGDCTSEMVSKSC 1234

  Fly   451 KHEPEVH-INDTGPPRGQAESDPE---------PERNEEHPSFGDDIQAANDECQECQPETE--- 502
            ....|:| ::.|.||: |.:...:         ..:......|..|...:::.|.:.:...|
Mouse  1235 NSSCEMHMVSKTNPPK-QVDDQSDGLLTSNSCTVSQRSTGACFLTDGVYSHEACAQKEGVYEGAC 1298

  Fly   503 -SDK--ISVAACDDIPSVSVKQEPEYDGYEKQTGVKQEPLKLKLKITKNHGKLNSSLIDDLDEAG 564
             ||:  |.:..|..|.||..|:....|..|     ..|.||...|:.|....|..|:..: |...
Mouse  1299 LSDETHIPIRDCHTIHSVHSKENKCTDDLE-----STEELKTVDKVPKGLSILADSMYKN-DSNV 1357

  Fly   565 QAFGRSSKKKKKRKHKEREKEASNETENCRTESQNQPAIKI--KQEPVDYAPEATVMTTIPMTQF 627
            ..|...:|...:|....:....|::..:...|.||.|..||  |::.:....|.:..:..|.: .
Mouse  1358 STFQNVNKLSSQRTLLSKTYLDSDKDYSPLEEFQNCPRKKIVNKKKSISSDKEESRTSEEPRS-I 1421

  Fly   628 ESSLNESERSEEVDEAMIQSQEDVKPNRMELDRMMQISNVTSGVDMAEEAMALERAEEACPEDSL 692
            .:|:..|||: .:.|  ::|.|:::.....:..|    ||              |||:...::::
Mouse  1422 TNSMTSSERN-AISE--LESFEELESQDTSIFNM----NV--------------RAEKKSTKETM 1465

  Fly   693 HKVKSVKSTARKST---GGAERKTYSPPRTNTLPQIVAVVSGESAFNMISIKPEPRNLGYGDEEP 754
            .|    :|.||.|:   ..:.||.....|.||      .:...:|...::    |.:|.:.   .
Mouse  1466 QK----QSEARMSSELINVSGRKIIEQERRNT------AILETTARGQVT----PPSLAFC---Y 1513

  Fly   755 EDQRETTEEINHNDMMEEEKEYIGSLD---LSDVSVKQERELDICEIDAVHRN--GLEKSD--ED 812
            :..:.|.:||:..:.....|:.:.|::   .|:.|:..::.         ||:  .|:.||  .|
Mouse  1514 DSNKNTEKEISEGETKMRVKKMVDSMENESYSESSLNFKKH---------HRSPGTLDWSDYGSD 1569

  Fly   813 DDDG----------NEDSASSADEAEEAMERDTEERIYREIEL--PP----------------LE 849
            .:.|          |:||....:.....::| ..|::|.:.|:  ||                :|
Mouse  1570 SESGYPCKASSNSHNDDSGQEKEPTRGIVKR-AIEKLYGKAEIIKPPFFHGSIHKSQVCPYNSVE 1633

  Fly   850 LQNESSRKDLESERM----DTEVS-TALPASETPSQTRDVLG-------VEK-SEASAFSLVIT- 900
            :|........|||..    ..:|| ::|...|.|....:.:|       :|. :::||...|.|
Mouse  1634 VQCAKKTNFYESECQSLVSSEQVSRSSLIFQEFPQVDANGMGDSFGDSSIENVTKSSAHDRVFTE 1698

  Fly   901 --------------------NICSQAVPQPSAACSNDIECSIGPSPSTTNEPHSHTVENVQSPAN 945
                                .:.|........|.:..::..|  ..::...|:||..|....|..
Mouse  1699 KENGKLIDNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTLI--DKNSIEVPYSHFGELAPGPTM 1761

  Fly   946 DLQTSAQVAIAAQSQPDPCIVSQPAASSESQADTKDLPPAASQIQTFNTESLPIHVHSETEDNSI 1010
            ...:|:::....|.....|........|:|:...:|.|.|  |.:|...|.:|.| |:|.:.|
Mouse  1762 AELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFPDA--QNKTCPKEKIPNH-HTEEKGN-- 1821

  Fly  1011 ENDASYLESRAQVDCQSAGTENPSVVLEQNESLPSGSCVSPIPENPSPGNSPPQH--DESESLDK 1073
                 |...|.   |.|.   ..:.|...|:..|  .|...|...|.||::....  .|.:||||
Mouse  1822 -----YPSERL---CTSV---TQAFVSAGNKVHP--VCSDAIKTQPLPGSNITHGALQEGDSLDK 1873

  Fly  1074 PEMAAGSAYCLATVSLDAPKDTEALALPPCDAAIIDSNYTSDEEQQNVLNHEL----------SE 1128
            .....|....:.||.:. |.:.|:....          |..|.:.:|.|:.:|          |:
Mouse  1874 LYALCGQHCPILTVIIQ-PVNEESRGFA----------YRKDSDIENSLDFQLWMKIYPFMPQSK 1927

  Fly  1129 QQLAIMEHRQLLVHEE--------------QPALLEVIPPGLSS--------------------- 1158
            :.:...:.|.:.|.||              ..::::::....:|
Mouse  1928 KHVFRSDGRNVSVGEEFAGNVIGDLCDQLYFKSMIDLVDQRANSLGKEINLKKFQLYLKKSFSDP 1992

  Fly  1159 -------------------------RPIEETENRINEQQQDLEQGEERPPRFQANDDSNINEIAE 1198
                                     :.|:|..|.:|           |.|    |...|.|::..
Mouse  1993 LSTSLLVVENRNSVSLSPSSWTDNFKSIDENNNFLN-----------RLP----NSSKNPNQVVR 2042

  Fly  1199 NNNNANIEREL 1209
            .|.|.....||
Mouse  2043 ENTNFQFHLEL 2053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	5/21 (24%)
		C2H2 Zn finger	203..224	CDD:275368	2/22 (9%)
		C2H2 Zn finger	233..253	CDD:275368	4/20 (20%)
		C2H2 Zn finger	262..282	CDD:275368	5/23 (22%)
		C2H2 Zn finger	297..314	CDD:275368	3/16 (19%)
Rp1	NP_035413.1	DCX	35..110	CDD:176357
		DCX	157..232	CDD:176357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..379
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..887		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1400..1430		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1595		4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900