DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1647 and T24E12.10

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_494646.2	Gene:	T24E12.10 / 188866	WormBaseID:	WBGene00020777	Length:	1318	Species:	Caenorhabditis elegans

Alignment Length:	740	Identity:	146/740 - (19%)
Similarity:	254/740 - (34%)	Gaps:	217/740 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 VKQEPLKLKLKITKNHGKLNSSLIDDLDEAGQAF--GRSSKKKKKRKHKEREKEASNETENCRTE 596
            |:|:|::|.....::   ||.:|:....:..:.|  |::::...:.:..|..:|.|.:......|
Worm     8 VEQDPVELATAAARD---LNLNLVQGTAQENRLFEHGQNTEAPVEVQGAEPNQEMSQDANQGSLE 69

  Fly   597 SQNQ----PAIK--------------IKQEPVDYAPEATVMTTIPMTQFESSLNESERSEEVDEA 643
            |:::    |.:.              |...|::.||:......:|..:.:..:.:.:::..|...
Worm    70 SEHKKVTFPGLDVYFSQIGELFKVSGILDAPIEPAPQKKKPNRVPNYKSKRKIQKKKKNIPVPTY 134

  Fly   644 MIQSQEDVKPNR-----------MELDRMMQ------ISNVTSGVDMAEEAMA-LERAEEACPED 690
            ...::...|..|           .|..|:.:      :|:.....|:..|::| ||.|:..  :|
Worm   135 TRSARRSTKSQRNLWQTNDVSSTSEATRIQEPIDWITLSDCDLDDDVPGESVAPLELAQNC--DD 197

  Fly   691 SLHKVKSVKSTARKSTGGAERKTYSPPRTNTLPQIVAVVSGESAFNMISIKPEPRNLGYGDEEPE 755
            .:..:....|::.......|.:..||     ||::                       .||.|.:
Worm   198 VVAPIAEPSSSSANHEASLEPQEVSP-----LPEV-----------------------QGDLEKD 234

  Fly   756 DQRETTEEINHNDMMEEEKEYIG--SLDLSDVSVKQERELDICEIDAVHRNGLEKSDEDDDDGNE 818
            |.    :.:..:|.:|.:.   |  ||::.....:...:.:.| :::|.......|.|..||..|
Worm   235 DH----DHLLPDDSVEPQN---GPTSLEVQGCEAEDGHDHEFC-VNSVVPQEPSPSPEVQDDQTE 291

  Fly   819 D----SASSADEAEEAMERDTEERIYREIELPPLELQNESSRKDLESERMDTEVSTALPASETPS 879
            |    |.|||                  :.:.|      |..||.....|..||.:..|.
Worm   292 DAQQFSVSSA------------------VPIAP------SIGKDDSQHEMSAEVQSMEPE----- 327

  Fly   880 QTRDVLGVEKSEASAFSLVITNICSQAVPQPSAACSNDIECSIGPSPSTTNEPHSHTVENVQSPA 944
                   |:...|..|             ....:|.|.:   :...|..:.|...:..|:    .
Worm   328 -------VQADFAKDF-------------HDHVSCVNSV---VPHEPVNSQEVQDYEAED----D 365

  Fly   945 NDLQTSAQVAIAAQSQPDPCIVSQPAASSESQADTKDLPPAASQIQTFN-TESLP---IHVHSET 1005
            |||  ||| ::|            |.|.|.|.|.|.: |....:||..: ...||   :...:||
Worm   366 NDL--SAQ-SVA------------PVAESFSSATTSE-PQEIVEIQEHHAAHQLPAVSVATFAET 414

  Fly  1006 EDNSIENDASYLESRAQVDCQSAGTENPSVVLEQNESLPSG--SCVSPIPENPSPG----NSPPQ 1064
            .||...::.| :|:............|    .|:....|.|  |.:.|:..:.||.    .:...
Worm   415 SDNKATDEMS-MEAPDDHQFSIHWVSN----FEEISFSPDGYNSLMDPLETSQSPEVRDYVNEDG 474

  Fly  1065 HDESESLDKPEMAAGSAYCLATVSLDAPKDTEALALPPCDAAIIDSNY----TSDEEQQNVLNHE 1125
            ||..:||.||:..:.|.......:.||             |..:..||    .|||        .
Worm   475 HDFCDSLIKPKELSQSTKVREAQAEDA-------------APSVSPNYEASLASDE--------A 518

  Fly  1126 LSEQQLAIMEHRQLLVHEEQPALLEVIPPGLSSRPIEETENR--------INEQQQDLEQGEERP 1182
            |.|..:.:.|.||.   ...||..:.        |||:.|..        |:|:...|......|
Worm   519 LCEIVVEVQEDRQF---SSSPASHDA--------PIEQQETSQSPENQYDIDEEAHHLSTQSVAP 572

  Fly  1183 PR-FQANDDSNINEIAENNNNANIE 1206
            .: |.|||::.....||.::|..:|
Worm   573 VKAFLANDETPHEISAEVHDNHQVE 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	297..314	CDD:275368
T24E12.10	NP_494646.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900