DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1523 and CAF4

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_012962.3	Gene:	CAF4 / 853908	SGDID:	S000001744	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	181	Identity:	44/181 - (24%)
Similarity:	77/181 - (42%)	Gaps:	44/181 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DNSLMRRIYSSMNMFNSYHANCWPTDAGRTGAIFNLEFNA--------DGNVVVAA--------- 66
            |.:|.|.||...:....      .|:...|..|.|.|.:.        |...:|:.
Yeast   391 DLNLSREIYLDHSPLKE------KTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHW 449

  Fly    67 --TERKCVLVFDAI---TQKEIFKVPDAHTDSVNC-----------IKFFDERLFATGSDDFTVA 115
              |..||:...|.|   |..:| |:|....::..|           ::.::..| |||:.|..|.
Yeast   450 DLTTGKCIQQLDLIFTPTHSDI-KMPARSLNNGACLLGTEAPMIGALQCYNSAL-ATGTKDGIVR 512

  Fly   116 LWDLRNMKQKLRVLHGHSNWVKNIEYSSKDKLLVSSGFDGSIFTWDINSQT 166
            ||||| :.:.:|:|.||::.:.::::.|:.  ||:...|.|:..||:.:.:
Yeast   513 LWDLR-VGKPVRLLEGHTDGITSLKFDSEK--LVTGSMDNSVRIWDLRTSS 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	39/157 (25%)
		WD40	<45..>218	CDD:225201	38/155 (25%)
		WD40 repeat	51..87	CDD:293791	13/57 (23%)
		WD40 repeat	95..129	CDD:293791	13/44 (30%)
		WD40 repeat	136..174	CDD:293791	7/31 (23%)
		WD40 repeat	181..210	CDD:293791
CAF4	NP_012962.3	Caf4	65..124	CDD:402971
		WD40	318..641	CDD:238121	44/181 (24%)
		WD40 repeat	322..360	CDD:293791
		WD40 repeat	366..422	CDD:293791	9/36 (25%)
		WD40 repeat	427..461	CDD:293791	5/33 (15%)
		WD40 repeat	472..526	CDD:293791	15/55 (27%)
		WD40 repeat	532..563	CDD:293791	7/31 (23%)
		WD40 repeat	571..611	CDD:293791
		WD40 repeat	617..641	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900