DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1523 and GRWD1

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_113673.3	Gene:	GRWD1 / 83743	HGNCID:	21270	Length:	446	Species:	Homo sapiens

Alignment Length:	185	Identity:	41/185 - (22%)
Similarity:	70/185 - (37%)	Gaps:	40/185 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DDNSLMRRIYSSMNMFNSYHANCW---------------------PTD-----------AGRTGA 50
            |:.:.|:.|:|.........|..|                     |||           .|.|.:
Human   199 DEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRS 263

  Fly    51 IFNLEFNADGNVVVAATERKC-VLVFD---AITQKEIFKVPDAHTDSVNCIKFF-DERLFATGSD 110
            :.:|:::...|.|.|:..... :.::|   |.::..:.....||...||.|.:. .|....:|.|
Human   264 VEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGD 328

  Fly   111 DFTVALWDLRNMK--QKLRVLHGHSNWVKNIEYSSKDK-LLVSSGFDGSIFTWDI 162
            |..:.:||||..|  ..:.....|...|.::|:..:|. :..:||.|..|..||:
Human   329 DGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDL 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	34/139 (24%)
		WD40	<45..>218	CDD:225201	32/126 (25%)
		WD40 repeat	51..87	CDD:293791	6/39 (15%)
		WD40 repeat	95..129	CDD:293791	11/36 (31%)
		WD40 repeat	136..174	CDD:293791	9/28 (32%)
		WD40 repeat	181..210	CDD:293791
GRWD1	NP_113673.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CAF1C_H4-bd	44..111	CDD:289068
		WD 1	54..110
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..141
		WD 2	163..204		1/4 (25%)
		WD40	<197..>383	CDD:225201	40/183 (22%)
		WD40	204..>384	CDD:295369	40/180 (22%)
		WD 3	205..250		7/44 (16%)
		WD40 repeat	218..259	CDD:293791	5/40 (13%)
		WD 4	251..297		8/45 (18%)
		WD40 repeat	265..306	CDD:293791	6/40 (15%)
		WD 5	298..343		14/44 (32%)
		WD40 repeat	311..350	CDD:293791	12/38 (32%)
		WD 6	344..405		10/40 (25%)
		WD 7	406..442
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910