DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1523 and AgaP_AGAP010152

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	XP_554046.3	Gene:	AgaP_AGAP010152 / 3292129	VectorBaseID:	AGAP010152	Length:	950	Species:	Anopheles gambiae

Alignment Length:	473	Identity:	84/473 - (17%)
Similarity:	173/473 - (36%)	Gaps:	114/473 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YSSMNMFNSYHANCWPTDAGRTGAIFNLEFNADGNVVVAATERKCVL-----------VFDAITQ 80
            |..|:..:.|.    |....:.|.:.|          ::.|::.|.:           :.:.:.|
Mosquito   409 YYHMSGAHKYE----PVRCKQFGQVSN----------ISGTDKMCFIGTQQGSIYITGLDENLKQ 459

  Fly    81 KEIFKVPDAHTDSVNCIKFFDERLFATGSDDFTVALWDLRN-----MKQKLRVLHGHSNWVKNIE 140
            ....||.:.:..||.    :.:...|.||:|..:.|.:|.:     .:.::..|.||:..:..::
Mosquito   460 LYCHKVANRYISSVE----YKQNYLAVGSNDHAIRLINLSDGFDGEQENEIITLEGHTEGICKVK 520

  Fly   141 YSSKD-KLLVSSGFDGSIFTWDINSQTEQGLISQRVFHASGLMRCRISPTGDKLVLCTSGGYIMI 204
            ::..| .||:||.:|.||..||..|.|...:...:.| |.|.:   .||..:.::|....|  :.
Mosquito   521 WNRGDTMLLLSSSYDCSIRIWDALSATCLSVFYTKSF-AYGAI---FSPLDENIILYVGKG--IP 579

  Fly   205 IHHLDLTTLHKDLCGFRPGIYRLMQLGEQYIPQAA--KYDHV-FSKRQKKNRVELVTDFPENNDA 266
            :...|.|..|                  ..:|:|:  ||..: |:..:....||.:.........
Mosquito   580 LSSYDYTKQH------------------DKVPKASSKKYPKIKFATLEDSKPVETMPGKKRGRGN 626

  Fly   267 EMIMALQIHPHCCCMLTRNVSCDEQSEWTCIHDINEEPVRSEDEQDEVEPQPKRKRVSTTLASRS 331
            :...|:.:          |.:.|:.::     ::.:..::   |...|:|.|.....:|...:..
Mosquito   627 KQPAAVSV----------NEAVDQLTD-----EVKKVTLK---EGAAVKPMPTPTLATTLPLTYR 673

  Fly   332 SLNESQD--QDTVGL--TPRQARRPLRVSSVQVFQLDNSGAGRGASD-------NPSVLTRSDSF 385
            ..|:.:|  :..|.|  ||.....|.::..      |.:|:...:.|       .|..:.:....
Mosquito   674 ETNKVKDVLECIVKLLHTPDPEPEPTKLDE------DENGSDNESLDEEFNRLIKPKAIEQKQPV 732

  Fly   386 I-PDIWAAEVTVQER---------AIRQNRARVSNNHVSGYNFVYAISSGVLPLRQL---GANSL 437
            : |.:..:|::..:.         :..||..::.......:......|.|::.|.||   ..:::
Mosquito   733 VEPPVNDSEMSAPDEKMFYNERLFSTEQNLKQLIEEEAKMHTITDVSSIGMVMLPQLLHKLKDTI 797

  Fly   438 MGSST----SPRPLTTPP 451
            :|..|    :|:.|...|
Mosquito   798 LGCITKKKLTPQMLALAP 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	40/208 (19%)
		WD40	<45..>218	CDD:225201	40/189 (21%)
		WD40 repeat	51..87	CDD:293791	5/46 (11%)
		WD40 repeat	95..129	CDD:293791	6/38 (16%)
		WD40 repeat	136..174	CDD:293791	12/38 (32%)
		WD40 repeat	181..210	CDD:293791	4/28 (14%)
AgaP_AGAP010152	XP_554046.3	WD40	250..585	CDD:225201	41/199 (21%)
		WD40 repeat	338..373	CDD:293791
		WD40 repeat	380..424	CDD:293791	4/18 (22%)
		WD40	<432..>572	CDD:295369	33/147 (22%)
		WD40 repeat	471..511	CDD:293791	9/43 (21%)
		WD40 repeat	516..552	CDD:293791	12/35 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900