DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1523 and AgaP_AGAP008003

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	XP_555462.3	Gene:	AgaP_AGAP008003 / 3291629	VectorBaseID:	AGAP008003	Length:	1497	Species:	Anopheles gambiae

Alignment Length:	646	Identity:	129/646 - (19%)
Similarity:	217/646 - (33%)	Gaps:	189/646 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PDAHTDSVNCIKFF--DERLFATGSDDFTVALW----DLRNMKQKLRVLHGHSNWVKNIEYSS-- 143
            |:..|..|:.: |.  |:::.|||..|..:.||    |...|..:. :|.||:..|..:..:|
Mosquito    15 PNTPTHCVSSV-FLSRDQKILATGCYDGQICLWQVDPDTLQMTPRC-LLVGHTAPVLCLTRASII 77

  Fly   144 -KDKLLVSSGFDGSIFTWDI--NSQTEQGLISQ-----RVFHASGLMRCRISPTGDKLVLCTSGG 200
             .:..||||..:|.:.|||:  ...||...:.|     :.:|   :..|      |.:.|..:|.
Mosquito    78 QDNNFLVSSSENGEMCTWDLVDGKCTESIKMPQVHTNIQAYH---MANC------DDIRLFCNGY 133

  Fly   201 Y--IMIIHHLDLTTLHKDLCGFRPGIYRLMQLGEQYIPQAAKYDHVFSKRQKKNRVELV------ 257
            |  ||::....|..|   .|           |..:..|......||....::|:.|.|.
Mosquito   134 YAEIMVMDPFSLEVL---FC-----------LSSKVNPDWISALHVLRPSKRKDDVVLAITTTGT 184

  Fly   258 ----------TDFPE---NNDAEMIMALQ-IHPHCCCMLTRNVSCDEQSEWTCIHDINEEPVRSE 308
                      ..:.|   .|:::.|..|. |..:||....|.|.......|. |:|..:..|..
Mosquito   185 VKVWTLLGNENKYSEPIYENESKQIRCLNAITMNCCSQNQRTVLIVCAKYWQ-IYDAGDFTVLC- 247

  Fly   309 DEQDEVEPQPKRKRVSTTLAS------------------RSSLNESQD-------QDTVGL---T 345
               ..:.|..:|......|::                  .:|:.:::|       :||..|   .
Mosquito   248 ---SVISPSGERWMGGDFLSNDRVILWSDEGKGYLFRLPANSIPDNKDFHGPSVGKDTPFLYCIL 309

  Fly   346 PRQARRPLRV-SSVQVFQLDNSGAGRGASDNPSVLTRSDS--FIPDIWAA---------EVTVQE 398
            .:...:||.. .::::...:.||      .....|.|.||  :: :|||.         ::..|:
Mosquito   310 SQTGEKPLSCPPTMKLVTSNRSG------KTQKYLLRGDSEGYV-NIWAVPDISMEQIKQIQTQK 367

  Fly   399 RAIRQNRARVSNNHVSGYNFVYAISSGVLPLRQLGANS-----LMGSSTSPR-----------PL 447
            :......:.:..:.:..:|.:..:..|:|.  ||..||     |..|...|:           .:
Mosquito   368 QHPASLESTICTSLLEAWNKMNPLPVGILD--QLYQNSEPMIKLTASIYLPQQSRLVVGREDGSI 430

  Fly   448 TTPPPTESNQSSSSSSSSSSSSSSSSSSNNSDTTVRLEI--GNRLRLRSFNSPVTTPTFKENGHS 510
            ...|.|:                          ||.|.:  ||..:...:     .|....||||
Mosquito   431 IIVPATQ--------------------------TVMLHLLHGNHQQFSDW-----PPHQILNGHS 464

  Fly   511 ILVNAKKLLYYAAETNTKPGFIKEPG--FSA------DGRVV---CSPYGNGVRLFGYSEDC--- 561
            ..||. .|....|.:......:...|  |:.      .|.::   |...|...:|......|
Mosquito   465 GRVNC-LLCPSLAHSRYDKSHLVSGGVDFAVCLWDLYSGSLIHRFCVHAGEITQLLVPPPTCSPR 528

  Fly   562 -----CDYPKCQAFEEVKSKPRKLVELAKITEHQDVVLCAKFSPREPLLVTGCNGGEV-TW 616
                 |......:...:..:.||.|.||  :.|...|:..|:.|.:..|:.||:.|.| .|
Mosquito   529 ILKCICSVASDHSVTLLSLQERKCVTLA--SRHLFPVISIKWRPLDDFLIVGCSDGTVYVW 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	41/165 (25%)
		WD40	<45..>218	CDD:225201	39/148 (26%)
		WD40 repeat	51..87	CDD:293791	129/646 (20%)
		WD40 repeat	95..129	CDD:293791	10/39 (26%)
		WD40 repeat	136..174	CDD:293791	13/47 (28%)
		WD40 repeat	181..210	CDD:293791	7/30 (23%)
AgaP_AGAP008003	XP_555462.3	WD40	22..>188	CDD:295369	45/190 (24%)
		WD40 repeat	23..63	CDD:293791	11/41 (27%)
		WD40 repeat	68..107	CDD:293791	12/38 (32%)
		WD40	104..587	CDD:225201	101/553 (18%)
		WD40 repeat	118..152	CDD:293791	11/56 (20%)
		WD40 repeat	160..204	CDD:293791	6/43 (14%)
		WD40 repeat	212..251	CDD:293791	10/43 (23%)
		WD40 repeat	258..280	CDD:293791	1/21 (5%)
		WD40	408..>600	CDD:295369	42/214 (20%)
		WD40 repeat	409..462	CDD:293791	11/83 (13%)
		WD40 repeat	468..510	CDD:293791	6/42 (14%)
		WD40 repeat	515..556	CDD:293791	6/40 (15%)
		WD40 repeat	564..598	CDD:293791	8/24 (33%)
		WD40	<1336..>1441	CDD:225201
		WD40	<1371..1467	CDD:295369
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900