DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1523 and APAF1

DIOPT Version :10

Sequence 1:NP_651635.2 Gene:CG1523 / 43400 FlyBaseID:FBgn0039601 Length:621 Species:Drosophila melanogaster
Sequence 2:NP_863651.1 Gene:APAF1 / 317 HGNCID:576 Length:1248 Species:Homo sapiens


Alignment Length:652 Identity:137/652 - (21%)
Similarity:223/652 - (34%) Gaps:192/652 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 YHANCWPTD--------AGRTGAIFNLE-------------------FNADGNVVVAATERKCVL 73
            ||| |:..|        |.:|..:|..|                   |:.|...:...:..|.|.
Human   619 YHA-CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682

  Fly    74 VFDAITQKEIFKVPDAHTDSVNCIKFFDER---LFATGSDDFTVALWDLRNMKQKLRVLHGHSNW 135
            :::::| .|:....|.|::.|||..|.:..   |.||||.|..:.|||| |.|:....:.||:|.
Human   683 IWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL-NQKECRNTMFGHTNS 745

  Fly   136 VKNIEYSSKDKLLVSSGFDGSIFTWDINSQTEQGLISQRVFHAS----------GLMRCRISPTG 190
            |.:..:|..||||.|...||::..||..|..|:..|:.:.|..:          .:..|..|..|
Human   746 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810

  Fly   191 DKLVLC-----------TSG--GYIMIIHHLDLTTLHKDLCGFRPGIYRLMQLGEQYIPQAAKYD 242
            .::::.           |||  |.|...||..:     ..|.|.|..:..:....||.       
Human   811 ARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTI-----QYCDFSPQNHLAVVALSQYC------- 863

  Fly   243 HVFSKRQKKNRVELVTDFPENNDAEMIMALQIHPHCCCMLTRNVSCDEQSEWTCIHDINEEP--- 304
                       |||     .|.|:...:|               .|.....|  :|.:...|   
Human   864 -----------VEL-----WNTDSRSKVA---------------DCRGHLSW--VHGVMFSPDGS 895

  Fly   305 --VRSEDEQDEVEPQPKRKRVSTTLASRSSLNESQDQDTVGLTPRQARRPLRVSSVQVFQLDNSG 367
              :.|.|:|.....:.|:      :...|::...|:.|.|  ........|.|..::..||.|  
Human   896 SFLTSSDDQTIRLWETKK------VCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLIN-- 950

  Fly   368 AGRGASDNPSVLTRSDSFIPDIWAAEVTVQERAIRQNRARVS----NNHVSGYNFVYAISSGVLP 428
               |.:.....||                        .|:||    :.|:.  ...:...:|.:.
Human   951 ---GRTGQIDYLT------------------------EAQVSCCCLSPHLQ--YIAFGDENGAIE 986

  Fly   429 LRQLGANSLMGSSTSPRPLTTPPPTESNQSSSSSSSSSSSSSSSSSSNNSDTTV-RLEIGNRLRL 492
            :.:|..|.:..|.           .:..::......::...:..|||::::..| ..::...:.|
Human   987 ILELVNNRIFQSR-----------FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL 1040

  Fly   493 RSFNSPVTTPTFKENGHSILVNAKKLLYYAAETNTKPGFI----KEPGFSADGRVVCSPYGNGVR 553
            |....  |...|:      |:...:||.::.:...|...|    ||..|      ||  :...|.
Human  1041 RGHQE--TVKDFR------LLKNSRLLSWSFDGTVKVWNIITGNKEKDF------VC--HQGTVL 1089

  Fly   554 LFGYSEDCCDYPKCQAFEEVKSKPRK------LVELAKITEHQDVVLCAKFSPREPLLVTGCNGG 612
            ....|.|...:....|     .|..|      |:.|.::..|...|.|:.||....||.||.:.|
Human  1090 SCDISHDATKFSSTSA-----DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNG 1149

  Fly   613 EV 614
            |:
Human  1150 EI 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1523NP_651635.2 WD40 <46..>212 CDD:441893 55/210 (26%)
WD40 repeat 51..87 CDD:293791 8/54 (15%)
WD40 repeat 95..129 CDD:293791 15/36 (42%)
WD40 repeat 136..174 CDD:293791 14/37 (38%)
WD40 repeat 181..210 CDD:293791 10/41 (24%)
APAF1NP_863651.1 CARD_APAF1 7..92 CDD:260034
NB-ARC 129..374 CDD:395745
APAF1_C 453..587 CDD:465560
WD40 <604..912 CDD:441893 79/340 (23%)
WD 1-1 613..652 9/33 (27%)
WD40 repeat 623..655 CDD:293791 5/31 (16%)
WD 1-2 655..694 6/39 (15%)
WD40 repeat 660..697 CDD:293791 6/37 (16%)
WD 1-3 697..738 17/41 (41%)
WD40 repeat 703..741 CDD:293791 15/38 (39%)
WD 1-4 741..780 16/38 (42%)
WD40 repeat 746..791 CDD:293791 15/44 (34%)
WD 1-5 796..836 7/39 (18%)
WD40 repeat 802..870 CDD:293791 19/95 (20%)
WD40 805..1234 CDD:441893 85/463 (18%)
WD 1-6 838..877 13/81 (16%)
WD 1-7 880..910 6/31 (19%)
WD40 repeat 885..939 CDD:293791 10/61 (16%)
Interpropeller linker. /evidence=ECO:0000250 910..921 2/16 (13%)
WD 2-1 922..958 9/42 (21%)
WD 2-2 959..998 9/64 (14%)
WD40 repeat 964..990 CDD:293791 4/27 (15%)
WD 2-3 1001..1040 4/38 (11%)
WD40 repeat 1006..1030 CDD:293791 3/23 (13%)
WD 2-4 1042..1080 9/45 (20%)
WD40 repeat 1047..1082 CDD:293791 9/46 (20%)
WD 2-5 1083..1122 9/45 (20%)
WD40 repeat 1089..1124 CDD:293791 7/39 (18%)
WD 2-6 1125..1164 11/27 (41%)
WD40 repeat 1130..1172 CDD:293791 10/22 (45%)
WD 2-7 1175..1212
WD40 repeat 1180..1213 CDD:293791
WD 2-8 1213..1248
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.