DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1523 and Rbcn-3B

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001284797.1	Gene:	Rbcn-3B / 31155	FlyBaseID:	FBgn0023510	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	128/651 - (19%)
Similarity:	198/651 - (30%)	Gaps:	202/651 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PDAHTDSVNCIKFFDERL-FATGSDDFTVALWDLRNMKQKLR---VLHGHSNWVKNIEYSS---K 144
            |.|.|..::.:...|::. ..||..|..:.||.:.....|:.   :|.|||..|..:..:|   :
  Fly    15 PTAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSPRCLLVGHSAPVLCLVRASLLPE 79

  Fly   145 DKLLVSSGFDGSIFTWDINSQTEQGLISQRVFHASGLMRCRISPTGDKLVLCTSGGY---IMIIH 206
            :..||||..:|.:.|||:........:.....|.. :.....:.:.|..:.|.  ||   ||::.
  Fly    80 NNFLVSSSENGEMCTWDLTDGKCMEAVKLPQVHTQ-IQSYHTANSEDVRLFCI--GYYAEIMVMD 141

  Fly   207 HLDLTTLHKDLCGFRPGIYRLMQLGEQYIPQAAKYDHVFSKRQKKNRVELVTDFP---------- 261
            ...|..::              .|..:..|......||....::|:.|.|.....
  Fly   142 PFSLEVIY--------------VLSSKVKPDWISAIHVLRPMRRKDDVVLAITTTGTVKVWTLTG 192

  Fly   262 -ENNDAEMIMALQ---------IHPHCCCMLTRNVSCDEQSEWTCIHDINEEPVRSEDEQDEVEP 316
             ||..||.|...:         |..:||....|.|.......|. |:|..:..|..    ..:.|
  Fly   193 NENKHAEPIYENESKEIRCLNAITMNCCAQNQRTVLLVCTKYWQ-IYDAGDFTVLC----SVIAP 252

  Fly   317 QPKRKRVSTTLAS-RSSLNESQDQDTVGLTPR---------QARRPLRVSSVQVFQLDNSG---- 367
            ..:|.:....:.| |..|...:.:..:...|.         .::..:|.:....:.|.::|
  Fly   253 ARERWQGGDFITSDRVMLWTDEGKGYLYKLPANCIPDNKEFHSKSVVRDAPYLYYVLQHAGDKVL 317

  Fly   368 ---------AGRGASDNPSVLTRSDSFIPDIWAAEVTVQERAIRQNRARVSNNHVSGYNFVYAIS 423
                     .|.|...|   |.|.||                             .||..|:.:.
  Fly   318 SCPPAMKLLQGAGGQHN---LLRGDS-----------------------------EGYISVWNVP 350

  Fly   424 SGVLPLRQLGANSLMGSSTSPRPL--------------TTPPPTE-SNQSSSSSSSSSSSSSSSS 473
            .  :||..:  :.|......||||              ..|||.. .:|.|..:.|....:||..
  Fly   351 E--VPLDNI--SILQAKQMPPRPLKPHVCTSLVEAWSIMDPPPVGILDQLSRITESPVKLTSSIY 411

  Fly   474 SSNNSDTTVRLEIGNRLRLRSFNSPVTTPTFKENGHSILVNAKKLLYYAAETNTKPGFIKEPG-- 536
            ....|    ||.||                 :|:|..::|.|.:.:........|..|...|.
  Fly   412 LPQQS----RLVIG-----------------REDGSIVIVPATQTVMMQLLVGIKQNFSDWPSHQ 455

  Fly   537 --FSADGRVVC--------SPYGNGVRLFG-----------YS---------------------E 559
              :...|||.|        |.|.....|.|           ||                     |
  Fly   456 ILYGHRGRVNCLLCPSMIHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPE 520

  Fly   560 DC--------CDYPKCQAFEEVKSKPRKLVELAKITEHQDVVLCAKFSPREPLLVTGCNGGEV-T 615
            .|        |......:...|..:.||.|.||  :.|...|:..|:.|.:..|:.||:.|.| .
  Fly   521 SCSPRILKCICSVASDHSVTLVSLQERKCVTLA--SRHLFPVVTIKWRPLDDFLIVGCSDGSVYV 583

  Fly   616 W 616
            |
  Fly   584 W 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	33/157 (21%)
		WD40	<45..>218	CDD:225201	32/140 (23%)
		WD40 repeat	51..87	CDD:293791	128/651 (20%)
		WD40 repeat	95..129	CDD:293791	7/37 (19%)
		WD40 repeat	136..174	CDD:293791	10/40 (25%)
		WD40 repeat	181..210	CDD:293791	6/31 (19%)
Rbcn-3B	NP_001284797.1	WD40	<11..>204	CDD:225201	44/205 (21%)
		WD40 repeat	20..63	CDD:293791	8/42 (19%)
		WD40	<22..202	CDD:295369	40/196 (20%)
		WD40 repeat	68..107	CDD:293791	10/38 (26%)
		WD40 repeat	118..152	CDD:293791	7/49 (14%)
		WD40 repeat	160..204	CDD:293791	10/43 (23%)
		WD40 repeat	212..251	CDD:293791	9/43 (21%)
		WD40 repeat	406..459	CDD:293791	14/73 (19%)
		WD40	<449..>607	CDD:225201	30/138 (22%)
		WD40	453..>597	CDD:295369	29/134 (22%)
		WD40 repeat	513..555	CDD:293791	9/43 (21%)
		WD40 repeat	560..596	CDD:293791	9/25 (36%)
		WD40	<1395..>1469	CDD:225201
		WD40	<1399..1495	CDD:295369
		WD40 repeat	1439..1466	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900