DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1523 and Apaf1

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001036023.1	Gene:	Apaf1 / 11783	MGIID:	1306796	Length:	1249	Species:	Mus musculus

Alignment Length:	701	Identity:	140/701 - (19%)
Similarity:	236/701 - (33%)	Gaps:	235/701 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YHANCWPTD--------AGRTGAIFNLE-------------------FNADGNVVVAATERKCVL 73
            ||| |:..|        |.:|..:|..|                   |::|.:.:...:..|.|.
Mouse   619 YHA-CFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVK 682

  Fly    74 VFDAITQKEIFKVPDAHTDSVNCIKFFDER---LFATGSDDFTVALWDLRNMKQKLRVLHGHSNW 135
            ::|:.|.| :....|.|::.|||..|.::.   |.||||:||.:.|||| |.|:....:.||:|.
Mouse   683 IWDSATGK-LVHTYDEHSEQVNCCHFTNKSNHLLLATGSNDFFLKLWDL-NQKECRNTMFGHTNS 745

  Fly   136 VKNIEYSSKDKLLVSSGFDGSIFTWDINSQTEQGLISQRVFHASG----------LMRCRISPTG 190
            |.:..:|..|:||.|...||::..||:.|..|:..|:.:.|..|.          :..|..|..|
Mouse   746 VNHCRFSPDDELLASCSADGTLRLWDVRSANERKSINVKRFFLSSEDPPEDVEVIVKCCSWSADG 810

  Fly   191 DKLVLCTSGGYIMIIHHLD--LTTLHK------DLCGFRPGIYRLMQLGEQYIPQAAKYDHVFSK 247
            ||:::......::...|..  |..:|.      ..|.|.|                  |||:...
Mouse   811 DKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSP------------------YDHLAVI 857

  Fly   248 RQKKNRVELVTDFPENNDAEMIMALQIHPHCCCMLTRNVSCDEQSEWTCIHDINEEP------VR 306
            ...:..|||     .|.|:.:.:|               .|.....|  :|.:...|      ..
Mouse   858 ALSQYCVEL-----WNIDSRLKVA---------------DCRGHLSW--VHGVMFSPDGSSFLTA 900

  Fly   307 SEDEQDEVEPQPKRKRVSTTLASRSSLNESQDQDTVGLTPRQAR---------------RPLRVS 356
            |:|:...|....|..:.|..:..:......|:.:|:.|.....|               ...:||
Mouse   901 SDDQTIRVWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVS 965

  Fly   357 ------------------SVQVFQLDN-----SGAG--------RGASDNPSVLTRSDSFIPDIW 390
                              ::::.:|.|     ||.|        :..:|..::::.|:..:..:|
Mouse   966 CCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVW 1030

  Fly   391 AAEVTVQERAIRQNRARVSNNHVSGYNFVYAISSGVLPLRQLGANSLMGSSTS------------ 443
                               |.....|.|:.|....|...|.|..:.|:..|..
Mouse  1031 -------------------NWQTGDYVFLQAHQETVKDFRLLQDSRLLSWSFDGTVKVWNVITGR 1076

  Fly   444 -PRPLTTPPPTESNQSSSSSSSSSSSSSSSSSSNNSDTTVRLEIGNRLRLRSFNSPVTTPTFKEN 507
             .|..|.       ...:..|.:.||.::..||.::|.|.::          ::..:.:|..:..
Mouse  1077 IERDFTC-------HQGTVLSCAISSDATKFSSTSADKTAKI----------WSFDLLSPLHELK 1124

  Fly   508 GHSILVNAKKLLYYAAETNTKPGFIKEPGFSADGRVVCSPYGNG-VRLFGYSE-----DCCDYPK 566
            ||:                   |.::...||.||.::.:...|| :|::..|:     .|....
Mouse  1125 GHN-------------------GCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCAPIS- 1169

  Fly   567 CQAFEEVKSKPRKLVELAKITEHQDVVLCAKFSPREPLLVTGCNGGEVTWY 617
                          ||....| |...|....|||....||:.  ||.:.|:
Mouse  1170 --------------VEEGTAT-HGGWVTDVCFSPDSKTLVSA--GGYLKWW 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	60/239 (25%)
		WD40	<45..>218	CDD:225201	56/212 (26%)
		WD40 repeat	51..87	CDD:293791	9/54 (17%)
		WD40 repeat	95..129	CDD:293791	16/36 (44%)
		WD40 repeat	136..174	CDD:293791	13/37 (35%)
		WD40 repeat	181..210	CDD:293791	6/30 (20%)
Apaf1	NP_001036023.1	CARD_APAF1	7..92	CDD:260034
		NB-ARC	129..374	CDD:395745
		APAF1_C	453..587	CDD:407760
		WD40	607..910	CDD:238121	80/333 (24%)
		WD 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	613..652		9/33 (27%)
		WD40 repeat	623..655	CDD:293791	5/31 (16%)
		WD 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	655..694		7/39 (18%)
		WD40 repeat	661..697	CDD:293791	7/36 (19%)
		WD 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	697..738		18/41 (44%)
		WD40 repeat	702..740	CDD:293791	17/38 (45%)
		WD 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	741..780		15/38 (39%)
		WD40 repeat	747..789	CDD:293791	13/41 (32%)
		WD 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	796..837		7/40 (18%)
		WD40 repeat	801..837	CDD:293791	7/35 (20%)
		WD 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	838..877		12/76 (16%)
		WD40 repeat	843..882	CDD:293791	13/76 (17%)
		WD 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	880..910		6/31 (19%)
		WD40 repeat	885..909	CDD:293791	4/23 (17%)
		Interpropeller linker	910..921		2/10 (20%)
		WD 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	922..958		4/35 (11%)
		WD 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	959..998		4/38 (11%)
		WD40	961..1235	CDD:238121	54/316 (17%)
		WD40 repeat	964..999	CDD:293791	4/34 (12%)
		WD 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1001..1040		6/57 (11%)
		WD40 repeat	1006..1030	CDD:293791	2/23 (9%)
		WD 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1042..1080		6/37 (16%)
		WD40 repeat	1048..1082	CDD:293791	5/33 (15%)
		WD 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1083..1122		8/55 (15%)
		WD40 repeat	1089..1124	CDD:293791	8/44 (18%)
		WD 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1125..1164		11/57 (19%)
		WD40 repeat	1130..1174	CDD:293791	11/58 (19%)
		WD 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1176..1213		11/31 (35%)
		WD40 repeat	1181..1203	CDD:293791	8/23 (35%)
		WD 2-8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1214..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810