DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1523 and Grwd1

DIOPT Version :9

Sequence 1:	NP_651635.2	Gene:	CG1523 / 43400	FlyBaseID:	FBgn0039601	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_700468.2	Gene:	Grwd1 / 101612	MGIID:	2141989	Length:	446	Species:	Mus musculus

Alignment Length:	174	Identity:	38/174 - (21%)
Similarity:	69/174 - (39%)	Gaps:	43/174 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SMNMFNSYHANCWPTD----AGRTGAIFNLEF-----------NADGNV----VVAATERKCVLV 74
            :::::.......|..|    .|.|.::.:|::           :||.::    :.||..:.|:|.
Mouse   238 NVHLWTPTEGGSWNVDQRPFVGHTRSVEDLQWSPTEDTVFASCSADASIRIWDIRAAPGKACMLT 302

  Fly    75 FDAITQKEIFKVPDAHTDSVNCIKFF-DERLFATGSDDFTVALWDLRNMK--QKLRVLHGHSNWV 136
                       ...||...||.|.:. .|....:|.||..:.:||||..|  ..:.....|...|
Mouse   303 -----------TATAHDGDVNVISWSRREPFLLSGGDDGALKVWDLRQFKSGSPVATFKQHMAPV 356

  Fly   137 KNIEYSSKDK-LLVSSGFDGSIFTWDI---------NSQTEQGL 170
            .::|:..:|. :..:||.|..|..||:         .::|:.||
Mouse   357 TSVEWHPQDSGVFAASGADNQITQWDLAVERDPESGETETDPGL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1523	NP_651635.2	WD40	43..235	CDD:295369	37/160 (23%)
		WD40	<45..>218	CDD:225201	36/154 (23%)
		WD40 repeat	51..87	CDD:293791	7/50 (14%)
		WD40 repeat	95..129	CDD:293791	11/36 (31%)
		WD40 repeat	136..174	CDD:293791	12/45 (27%)
		WD40 repeat	181..210	CDD:293791
Grwd1	NP_700468.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		CAF1C_H4-bd	44..111	CDD:289068
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..141
		WD40 repeat	175..212	CDD:293791
		WD40	<194..>383	CDD:225201	34/155 (22%)
		WD40	206..>384	CDD:295369	35/156 (22%)
		WD 1	212..252		1/13 (8%)
		WD40 repeat	218..259	CDD:293791	2/20 (10%)
		WD 2	259..299		7/39 (18%)
		WD40 repeat	265..306	CDD:293791	7/51 (14%)
		WD 3	306..345		14/38 (37%)
		WD40 repeat	311..350	CDD:293791	12/38 (32%)
		WD 4	351..391		10/39 (26%)
		WD 5	412..445
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910