Protein Alignment Prp39 and PRP39

DIOPT Version :10

• Sequence 1: NP_733256.2
• Gene: Prp39 / 43399
• FlyBaseID: FBgn0039600
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_013667.1
• Gene: PRP39 / 854960
• SGDID: S000004509
• Length: 629
• Species: Saccharomyces cerevisiae
• Alignment Length: 603
• Identity: 115/603 - (19%)
• Similarity: 221/603 - (36%)
• Gaps: 195/603 - (32%)

  Fly   318 PSEKKLKVEESEPKEKKKEKERDKDKEKDKD----KDNNKDKEKERKKLPDLDKYWRAVKEDSTD 378
            |.|....:|:.||:         .|..:..|    :||..           |.:.:|.:  |.:|
Yeast     2 PDETNFTIEDIEPR---------PDALRGLDTQFLQDNTA-----------LVQAYRGL--DWSD 44

  Fly   379 FTGWTYLLQYVD---------NESDAEAAREAYDTFLSHYPYCYGYWRKYADYEKRK-GIKANCY 433
            .:..|.::..::         |:|...|........|..||..:|:|:::|..|.:. |:|.: .
Yeast    45 ISSLTQMVDVIEQTVVKYGNPNDSIKLALETILWQILRKYPLLFGFWKRFATIEYQLFGLKKS-I 108

  Fly   434 KVFERGLEAIPLSVDLWIHYLMHVKSNHGDDETFVRSQYERAVKACGLEFRSDKLWDAYIRWENE 498
            .|....::..|.|::||..||..:..|:.::..|:|:.:|.|....|.:|.|...||.:|.:|..
Yeast   109 AVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEIAKDLIGKQFLSHPFWDKFIEFEVG 173

  Fly   499 SKRYHRVVQIYDRLLAIPTQGYNGHFDNFQDLINQHDVTITLANEEVIRLRKDFHERQQSKSSKS 563
            .|.:|.|.:||:.::.:|...|...|.:::..:|:.::. |..|.::: |||
Yeast   174 QKNWHNVQRIYEYIIEVPLHQYARFFTSYKKFLNEKNLK-TTRNIDIV-LRK------------- 223

  Fly   564 SSKHRRDSSSSSKDKDSKEREREKDKDKDKDKDKEKRETVGGGVGKSPKDTSETQVDESDSTTDL 628
                                                               ::|.|:|.
Yeast   224 ---------------------------------------------------TQTTVNEI------ 231

  Fly   629 TTESESSHAASKPAMQIDFSDLSTLNDEEVVSIRDRAISARRKVHKLTVSAVTARWSFEEGIKRP 693
                                                                   |.||..||:|
Yeast   232 -------------------------------------------------------WQFESKIKQP 241

  Fly   694 YFHVKPLERAQLKNWKDYLDFEIEKG---DRERVLVLFERCLIACALYDEFWLKMLRYL--ESLE 753
            :|::..:....|:||..||.|..:..   |:|.|:.:|:||||.|..::..|:..:::|  :::.
Yeast   242 FFNLGQVLNDDLENWSRYLKFVTDPSKSLDKEFVMSVFDRCLIPCLYHENTWMMYIKWLTKKNIS 306

  Fly   754 DQSGVVDLVRDVYRRACRIHHPDKPSLHLMWAAFEECQMNFDDAA------EILQRIDQRCPNLL 812
            |     ::|.|:|::|......|..:|...:..|.:.:...::..      |.:.|..:..||.:
Yeast   307 D-----EVVVDIYQKANTFLPLDFKTLRYDFLRFLKRKYRSNNTLFNNIFNETVSRYLKIWPNDI 366

  Fly   813 QLSYRRINVERR---RGALDKC-RELYKHYIESTKNKGIAGSLAIKYARFLNKICHDLDAGLAAL 873
            .|....:.:.:|   :.:||:. :|:.:.....||         |......|.|.:.:||.:..
Yeast   367 LLMTEYLCMLKRHSFKNSLDQSPKEILEKQTSFTK---------ILETSITNYINNQIDAKVHL- 421

  Fly   874 QQALERDPANTRVALQMI 891
             |.|..|...:.|.:::|
Yeast   422 -QTLINDKNLSIVVVELI 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp39	NP_733256.2	PHA03169	11..>269	CDD:223003
		RNA14	359..>535	CDD:227438	45/185 (24%)
		Spy	755..>962	CDD:443119	28/147 (19%)
		TPR repeat	884..915	CDD:276808	2/8 (25%)
PRP39	NP_013667.1	RNA14	121..>217	CDD:227438	27/96 (28%)