Protein Alignment Prp39 and Prpf39

DIOPT Version :10

• Sequence 1: NP_733256.2
• Gene: Prp39 / 43399
• FlyBaseID: FBgn0039600
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_808474.2
• Gene: Prpf39 / 328110
• MGIID: 104602
• Length: 665
• Species: Mus musculus
• Alignment Length: 779
• Identity: 272/779 - (34%)
• Similarity: 391/779 - (50%)
• Gaps: 142/779 - (18%)

  Fly   274 RKAENESVKSTEDKDASSHESSTKDKSSEQYNPGSPTSESNDAQPSEKKLKVEESEPKEKKKEKE 338
            |.::|.|..::.:.....|    .|.|:|..|. :...:|.||.|| .....||:|.
Mouse    10 RNSDNGSTGNSSEVAVVEH----PDFSTEIMNV-TEMEQSPDASPS-AHASTEENEM-------- 60

  Fly   339 RDKDKEKDKDKDNNKDKEKERKKLPDLDKYWRAVKEDSTDFTGWTYLLQYVDNESDAEAAREAYD 403
                    .:..|....|.|....|:.:|:|:.|:.:..|||||.||||||:.|:...|||:|:|
Mouse    61 --------ANAVNLPVTEAEGDFPPEFEKFWKTVEMNPQDFTGWVYLLQYVEQENHLMAARKAFD 117

  Fly   404 TFLSHYPYCYGYWRKYADYEKRKGIKANCYKVFERGLEAIPLSVDLWIHYLMHVKS--NHGDDE- 465
            .|..|||||||||:||||.|||........:|:.|||:||||||||||||:..:|.  :.||.|
Mouse   118 KFFVHYPYCYGYWKKYADLEKRHDNIKQSDEVYRRGLQAIPLSVDLWIHYINFLKETLDPGDQET 182

  Fly   466 -TFVRSQYERAVKACGLEFRSDKLWDAYIRWENESKRYHRVVQIYDRLLAIPTQGYNGHFDNFQD 529
             |.:|..:|.||.|.|.:|||||||:.||.||||......|..:|||:|.||||.|:.||..|::
Mouse   183 NTTIRGTFEHAVLAAGTDFRSDKLWEMYINWENEQGNLREVTAVYDRILGIPTQLYSHHFQRFKE 247

  Fly   530 LINQHDVTITLANEEVIRLRKDFHERQQSKSSKSSSKHRRDSSSSSKDKDSKEREREKDKDKDKD 594
            .:..:.....|..|:.|:||::.         .|.:.|..|......|..|
Mouse   248 HVQNNLPRDLLTGEQFIQLRREL---------ASVNGHSGDDGPPGDDLPS-------------- 289

  Fly   595 KDKEKRETVGGGVGKSPKDTSETQVDESDSTTDLTTESESSHAASKPAMQIDFSDLSTLNDEEVV 659
                       |:               :..||             ||..|          .|:.
Mouse   290 -----------GI---------------EDITD-------------PAKLI----------TEIE 305

  Fly   660 SIRDRAISARRKVHKLTVSAVTARWSFEEGIKRPYFHVKPLERAQLKNWKDYLDFEIEKGDRERV 724
            ::|.|.|...:::.......|:.||:||||||||||||||||:|||||||:||:||||.|..|||
Mouse   306 NMRHRIIEIHQEMFNYNEHEVSKRWTFEEGIKRPYFHVKPLEKAQLKNWKEYLEFEIENGTHERV 370

  Fly   725 LVLFERCLIACALYDEFWLKMLRYLESLEDQSGVVDLVRDVYRRACRIHHPDKPSLHLMWAAFEE 789
            :||||||:|:||||:|||:|..:|:|:..     ::.||.|:.|||.:|.|.||..|::||||||
Mouse   371 VVLFERCVISCALYEEFWIKYAKYMENHS-----IEGVRHVFSRACTVHLPKKPMAHMLWAAFEE 430

  Fly   790 CQMNFDDAAEILQRIDQRCPNLLQLSYRRINVERRRGALDKCRELYKHYIESTKNKGIAGSLAIK 854
            .|.|.::|..||:..::....|..:..||:::|||.|.:::...|.:..|::.|:...:...|||
Mouse   431 QQGNINEARIILRTFEECVLGLAMVRLRRVSLERRHGNMEEAEHLLQDAIKNAKSNNESSFYAIK 495

  Fly   855 YARFLNKICHDLDAGLAALQQALERDPANTRVALQMIDL---CLQRPKVDEQEVVEIMDKFMARA 916
            .||.|.||..:|......|.:|:|:|..||::.|.::::   |  ..|.:|:.::...||.: ..
Mouse   496 LARHLFKIQKNLPKSRKVLLEAIEKDKENTKLYLNLLEMEYSC--DLKQNEENILNCFDKAI-HG 557

  Fly   917 DIEPDQKVLFAQRKVEFLEDFGSTARGLQDA----QRALQQALTKAKEAQKKSDGSPSRKNSSSS 977
            .:....::.|:||||||||||||....|.:|    |..|::..|..::|:..|: .|..|.:.:.
Mouse   558 SLPIKMRITFSQRKVEFLEDFGSDVNKLLNAYDEHQTLLKEQDTLKRKAENGSE-EPEEKKAHTE 621

  Fly   978 KEGPVPTGSAAAAYNNGGSAAAVAGYNYGAANPYYGQQNTAAAYPSQTPQQASYDSYYNQWGYG 1041
                   ..::|...:|...|..|.|||.|...|                     :|.|.|.||
Mouse   622 -------DLSSAQIIDGDLQANQAAYNYSAWYQY---------------------NYQNPWNYG 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp39	NP_733256.2	PHA03169	11..>269	CDD:223003
		RNA14	359..>535	CDD:227438	91/179 (51%)
		Spy	755..>962	CDD:443119	71/213 (33%)
		TPR repeat	884..915	CDD:276808	7/33 (21%)
Prpf39	NP_808474.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		3/17 (18%)
		RNA14	68..>538	CDD:227438	214/546 (39%)
		HAT 1	107..139		20/31 (65%)
		HAT 2	141..173		16/31 (52%)
		HAT 3	181..216		19/34 (56%)
		HAT 4	218..251		13/32 (41%)
		HAT 6	365..397		20/31 (65%)
		HAT 7	402..434		18/31 (58%)
		TPR repeat	453..481	CDD:276809	7/27 (26%)
		TPR repeat	486..520	CDD:276809	11/33 (33%)
		TPR repeat	525..555	CDD:276809	7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	599..625		5/33 (15%)