Protein Alignment Prp39 and Prpf39

DIOPT Version :10

• Sequence 1: NP_733256.2
• Gene: Prp39 / 43399
• FlyBaseID: FBgn0039600
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001101496.2
• Gene: Prpf39 / 314171
• RGDID: 1308702
• Length: 664
• Species: Rattus norvegicus
• Alignment Length: 785
• Identity: 273/785 - (34%)
• Similarity: 393/785 - (50%)
• Gaps: 150/785 - (19%)

  Fly   277 ENESVKSTEDKDASSHESSTK------DKSSEQYNPGSPTSESNDAQPSEKKLKVEESEPKEKKK 335
            :|..:....:.|..|..:|::      |.|:|..|. :...:|.||.|| .::..||:|
  Rat     2 QNSHMDEYRNSDNGSTGNSSEVVIEHPDFSTEIMNV-TEMEQSPDASPS-VRVSTEENE------ 58

  Fly   336 EKERDKDKEKDKDKDNNKD---KEKERKKLPDLDKYWRAVKEDSTDFTGWTYLLQYVDNESDAEA 397
                         ..|..|   .|.|....|:.:|:|:.|:.:..|||||.||||||:.|:...|
  Rat    59 -------------MANAVDLPVTETEGNFPPEFEKFWKTVETNPQDFTGWVYLLQYVEQENHLMA 110

  Fly   398 AREAYDTFLSHYPYCYGYWRKYADYEKRKGIKANCYKVFERGLEAIPLSVDLWIHYLMHVKS--N 460
            ||:|:|.|..|||||||||:||||.|||........:|:.|||:||||||||||||:..:|.  :
  Rat   111 ARKAFDKFFIHYPYCYGYWKKYADLEKRHDNIKQSDEVYRRGLQAIPLSVDLWIHYINFLKETLD 175

  Fly   461 HGDDET--FVRSQYERAVKACGLEFRSDKLWDAYIRWENESKRYHRVVQIYDRLLAIPTQGYNGH 523
            .||.||  .:|..:|.||.|.|.:|||||||:.||.||||......|..:|||:|.||||.|:.|
  Rat   176 PGDPETNSTIRGTFEHAVLAAGTDFRSDKLWEMYINWENEQGNLREVTAVYDRILGIPTQLYSHH 240

  Fly   524 FDNFQDLINQHDVTITLANEEVIRLRKDFHERQQSKSSKSSSKHRRDSSSSSKDKDSKEREREKD 588
            |..|::.:..:.....|..|:.|:||::.         .|.:.|..|......|..|
  Rat   241 FQRFKEHVQNNLPRDLLTGEQFIQLRREL---------ASVNGHNGDDGPPGDDLPS-------- 288

  Fly   589 KDKDKDKDKEKRETVGGGVGKSPKDTSETQVDESDSTTDLTTESESSHAASKPAMQIDFSDLSTL 653
                             |:               :..||             ||..|
  Rat   289 -----------------GI---------------EDITD-------------PAKLI-------- 300

  Fly   654 NDEEVVSIRDRAISARRKVHKLTVSAVTARWSFEEGIKRPYFHVKPLERAQLKNWKDYLDFEIEK 718
              .|:.::|.|.|...:::.......|:.||:||||||||||||||||:|||||||:||:||||.
  Rat   301 --TEIENMRHRIIEIHQEMFNYNEHEVSKRWTFEEGIKRPYFHVKPLEKAQLKNWKEYLEFEIEN 363

  Fly   719 GDRERVLVLFERCLIACALYDEFWLKMLRYLESLEDQSGVVDLVRDVYRRACRIHHPDKPSLHLM 783
            |..|||:||||||:|:||||:|||:|..:|:|:..     ::.||.|:.|||.:|.|.||..|::
  Rat   364 GTHERVVVLFERCVISCALYEEFWIKYAKYMENHS-----IEGVRHVFSRACTVHLPKKPMAHML 423

  Fly   784 WAAFEECQMNFDDAAEILQRIDQRCPNLLQLSYRRINVERRRGALDKCRELYKHYIESTKNKGIA 848
            ||||||.|.|.::|..||:..::....|..:..||:::|||.|.:::...|.:..|.:.|:...:
  Rat   424 WAAFEEQQGNINEARIILRTFEECVLGLAMVRLRRVSLERRHGNMEEAEHLLQDAIRNAKSNNES 488

  Fly   849 GSLAIKYARFLNKICHDLDAGLAALQQALERDPANTRVALQMIDL---CLQRPKVDEQEVVEIMD 910
            ...|||.||.|.||..:|......|.:|:|:|..||::.|.::::   |  ..|.:|:.::...|
  Rat   489 SFYAIKLARHLFKIQKNLPKSRKVLLEAIEKDKENTKLYLNLLEMEYSC--DLKQNEENILNCFD 551

  Fly   911 KFMARADIEPDQKVLFAQRKVEFLEDFGSTARGLQDA----QRALQQALTKAKEAQKKSDGSPSR 971
            |.: ...:....::.|:||||||||||||....|.:|    |..|::..|..::|:..|: .|..
  Rat   552 KAI-HGSLPIKMRITFSQRKVEFLEDFGSDVNKLLNAYDEHQTLLKEQDTLKRKAENGSE-EPEE 614

  Fly   972 KNSSSSKEGPVPTGSAAAAYNNGGSAAAVAGYNYGAANPYYGQQNTAAAYPSQTPQQASYDSYYN 1036
            |.:.:.       ..::|...:|...|..|.|||.|...|                     :|.|
  Rat   615 KKAHTE-------DVSSAQIIDGDLQANQAAYNYSAWYQY---------------------NYQN 651

  Fly  1037 QWGYG 1041
            .|.||
  Rat   652 PWNYG 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp39	NP_733256.2	PHA03169	11..>269	CDD:223003
		RNA14	359..>535	CDD:227438	91/179 (51%)
		Spy	755..>962	CDD:443119	71/213 (33%)
		TPR repeat	884..915	CDD:276808	7/33 (21%)
Prpf39	NP_001101496.2	RNA14	67..>537	CDD:227438	214/546 (39%)
		TPR repeat	452..480	CDD:276809	7/27 (26%)
		TPR repeat	485..519	CDD:276809	11/33 (33%)
		TPR repeat	524..554	CDD:276809	7/31 (23%)