Protein Alignment Prp39 and prp-39

DIOPT Version :10

• Sequence 1: NP_733256.2
• Gene: Prp39 / 43399
• FlyBaseID: FBgn0039600
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_504495.1
• Gene: prp-39 / 178955
• WormBaseID: WBGene00017768
• Length: 710
• Species: Caenorhabditis elegans
• Alignment Length: 704
• Identity: 194/704 - (27%)
• Similarity: 327/704 - (46%)
• Gaps: 132/704 - (18%)

  Fly   297 KDKSSEQYNPGSPTSESNDAQPSEKKLKVEESEPKEKKKEKERDKDKEKDKDKDNNKDKEKERKK 361
            :|:||        :|:::|...|....|.|:|.  .::.::.||.|:::|:.:.:.......|.:
 Worm     3 RDRSS--------SSDTDDYYRSSSSRKREDSH--RRRDDRHRDSDRDRDRRRRSRSRSNSNRHR 57

  Fly   362 L------------------------PDLDKYWRAVKEDSTDFTGWTYLLQYVDNESDAEAAREAY 402
            .                        |.:..::.....|..||..|..:|..||...|.:.|||.|
 Worm    58 TTGGSQRSRSSRHGSDYKDTSLMTRPSVASHFGTPPIDVADFDNWVNILAKVDQSDDVDFAREKY 122

  Fly   403 DTFLSHYPYCYGYWRKYADYEKRKGIKANCYKVFERGLEAIPLSVDLWIHYLMHVKSNHGDDETF 467
            .:|||.||.|||:|:|||:|||:.|..|....|:|:|:.:||||:|||:.|...||:........
 Worm   123 RSFLSRYPNCYGFWQKYAEYEKKMGNIAEAKAVWEKGIISIPLSIDLWLGYTADVKNIKNFPPES 187

  Fly   468 VRSQYERAVKACGLEFRSDKLWDAYIRWE-----------NESKRYHRVVQIYDRLLAIPTQGYN 521
            :|..|.||::..|||::||:||...|.:|           |.:....|:..::|:||:.||....
 Worm   188 LRDLYARAIEIAGLEYQSDRLWLEAIGFERAVYMDELCKGNTNASCKRIGVLFDKLLSTPTFHAP 252

  Fly   522 GHFDNFQDLINQHDVTITLANEEVIRLRKDFHERQQSKSSKSSSKHRRDSSSSSKDKDSKERERE 586
            .|||.:...:|..:..:.|::.|.
 Worm   253 SHFDRYVQYLNTIEPHLLLSDREY----------------------------------------- 276

  Fly   587 KDKDKDKDKDKEKRETVGGGVGKSPKDTSE-------TQVDESDSTTDLTTESESSHAASKPAMQ 644
                      :|..:.|...:|||.::..:       .|..|:.....:|..:|.:...:..::|
 Worm   277 ----------EEIMKMVCKQLGKSIEELVQQVQLSYICQSGENGMLNIMTESAEGTFPITVNSLQ 331

  Fly   645 IDFSDLSTLNDEEVVSIRDRAISARRKVHKLTVSAVTARWSFEEGIKRPYFHVKPLERAQLKNWK 709
            .|.:.|..        ||...::.|::::...:.....|..||..|||||||||||:..||.||.
 Worm   332 HDPTALQL--------IRGEIVARRKRIYDKNMKECEIRAGFEANIKRPYFHVKPLDYPQLFNWM 388

  Fly   710 DYLDFEIEKGDRERVLVLFERCLIACALYDEFWLKMLRYL-ESLEDQSGVVDLVRDVYRRACRIH 773
            .||||||::|..|||.:||:||||.|:||:|||:|..|:. ::.:.::    ..|::|.:| :||
 Worm   389 SYLDFEIKEGHEERVKILFDRCLIPCSLYEEFWIKYARWTWKTYKSKT----KSREIYMKA-KIH 448

  Fly   774 HPDKPSLHLMWAAFEECQMNFDDAAEILQRIDQRCPNLLQLSYRRINVERRR------GA----- 827
            .|...:|.|..:.|||...|||||.:||....:..|..:.|..|.:.|.||:      ||
 Worm   449 CPTSLNLALSESGFEESVENFDDAIKILDNFREEYPGYVLLELRYLGVLRRKSEKEGHGAPSEFV 513

  Fly   828 LDKCRELYKHYIESTKNKGIAGSLAIKYARFLNKICHDLDAGLAALQQALERDPANTRVALQMID 892
            :::...|.:   :|..:..:....::|.||:..|...|.......|::|:..||.|.::..|.:|
 Worm   514 MNQYESLIR---DSQSSPNLHSFYSLKLARYHQKSRRDPKLAQKVLKKAISIDPFNLQLYSQYVD 575

  Fly   893 LCLQRPKVDEQEVVEIMDKFMARADIEPDQKVLFAQRKVEFLEDFGSTARGLQD 946
            :......:.|.:|::..|..: .:::..:.||.|:|||::|||:.|:....::|
 Worm   576 IAYSSESMSELDVIQSFDVAL-DSNLRLEDKVRFSQRKLDFLEELGNNILAVED 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp39	NP_733256.2	PHA03169	11..>269	CDD:223003
		RNA14	359..>535	CDD:227438	68/210 (32%)
		Spy	755..>962	CDD:443119	54/203 (27%)
		TPR repeat	884..915	CDD:276808	5/30 (17%)
prp-39	NP_504495.1	HAT	114..145	CDD:214642	19/30 (63%)
		HAT	398..427	CDD:214642	17/28 (61%)
		LapB	<468..>585	CDD:442196	29/119 (24%)