DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdn and ZNF251

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_612376.1	Gene:	ZNF251 / 90987	HGNCID:	13045	Length:	671	Species:	Homo sapiens

Alignment Length:	779	Identity:	164/779 - (21%)
Similarity:	271/779 - (34%)	Gaps:	197/779 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KGEGKRM--KEEAPSKKLPPKIYGGDAGTPTKAAHDEILSSLLRINNFDSISSIKDESLDIDLSA 67
            :.||:::  ::.|..:.:..:.||..|.........|::|.|.:......::.:..|..|| |.:
Human    26 QAEGRQLGPQQRALYRDVMLENYGNVASLGFPVPKPELISQLEQGKELWVLNLLGAEEPDI-LKS 89

  Fly    68 CVTISSASLVNGNSLSSTDFWRVLDESAQNNTELNLSSDVCRDDLAATSSSTVPSTLTSDNHSSS 132
            |..                     |.......||::.:....:::  .:...|...|..||..::
Human    90 CQK---------------------DSEVGTKKELSILNQKFSEEV--KTPEFVSRRLLRDNAQAA 131

  Fly   133 EFSVTFLRPEPPNAFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMPQSQLLQRKPKLPAATAV 197
            ||...:.|..          |.....|.|....|:...:|               |..|..||..
Human   132 EFREAWGREG----------KLKERVGNSAGQSLNKPNIH---------------KRVLTEATVG 171

  Fly   198 RLKVFKEEPPE-----------------EKHPPEQVVTKVEVCESELLPPSFTIFQQAKSAESVA 245
            |.:...|...|                 :::...:.|.|.::|              :|:.:..:
Human   172 RERSLGERTQECSAFDRNLNLDQNVVRLQRNKTGERVFKCDIC--------------SKTFKYNS 222

  Fly   246 DAASMPPPAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQREFEL 310
            |.:........| ||.|        |..|......:.:.|..|.  .|.....::|.||.:.|
Human   223 DLSRHQRSHTGE-KPYE--------CGRCGRAFTHSSNLVLHHH--IHTGNKPFKCDECGKTF-- 274

  Fly   311 LAGLKKHLKTHRTEGRKDTWKK---CPDCGKCLKLGS-MWMHRKIHSDNKKYQCDICGQKFVQKI 371
              ||..||:.||   |..|.:|   |.:|||.....| :..||.||:..|.|:|:.||:.|.|..
Human   275 --GLNSHLRLHR---RIHTGEKPFGCGECGKAFSRSSTLIQHRIIHTGEKPYKCNECGRGFSQSP 334

  Fly   372 NLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVH 436
            .||.|.|||:.|||:||..|.|.|...|.|.:|::.|...:.::|.:|||.:.....|.:|:.||
Human   335 QLTQHQRIHTGEKPHECSHCGKAFSRSSSLIQHERIHTGEKPHKCNQCGKAFSQSSSLFLHHRVH 399

  Fly   437 LEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGE 501
            ..::|:.|..|.::|..||.|.:|..||||.:|:.||.|.:.|......::| ||.|     |||
Human   400 TGEKPYVCNECGRAFGFNSHLTEHVRIHTGEKPYVCNECGKAFRRSSTLVQH-RRVH-----TGE 458

  Fly   502 HLENIPSYC-------SKKS---------TTNKAQKAAAAAAAAAAASSAVNPNELSASSELKAK 550
            .    |..|       |:.|         |..|.........|.:..|:.:...::.:....|.:
Human   459 K----PYQCVECGKAFSQSSQLTLHQRVHTGEKPYDCGDCGKAFSRRSTLIQHQKVHSGETRKCR 519

  Fly   551 ANLTSTAAPAPAKQARKKKQPQQATLAALGITLPAGTALQQVHPVPLAQQHQQEL----TTVLVP 611
            .:                           |.....|::|.....:|..::|.:..    ..:|..
Human   520 KH---------------------------GPAFVHGSSLTADGQIPTGEKHGRAFNHGANLILRW 557

  Fly   612 LAPPAPKQTKAKRERKQLAPKQLQQKPQLLQQGQPQQSSLEPIPAVPQIKKEPVQTQGPFLDLHG 676
            ......|........|..:|.....:.|::..|:                 :|.:.|.     .|
Human   558 TVHTGEKSFGCNEYGKAFSPTSRPTEDQIMHAGE-----------------KPYKCQE-----CG 600

  Fly   677 LSLTSAEELIMEQALEMEE----CGLYD---------APNANTEMGTSDNAISDSAAALHFQIK 727
            .:.:....||..|.....:    |.:|.         .|...|.:|... |::|.:......||
Human   601 NAFSGKSTLIQHQVTHTGQKPCHCSVYGKAFSQSSQLTPPQQTRVGEKP-ALNDGSKRYFIHIK 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		RPB9	333..425	CDD:224510	38/92 (41%)
		C2H2 Zn finger	333..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..369	CDD:290200	11/25 (44%)
		zf-C2H2	358..380	CDD:278523	10/21 (48%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		zf-H2C2_2	372..395	CDD:290200	13/22 (59%)
		zf-C2H2	386..408	CDD:278523	8/21 (38%)
		C2H2 Zn finger	388..436	CDD:275368	14/47 (30%)
		zf-H2C2_2	400..425	CDD:290200	7/24 (29%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	8/23 (35%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		zf-H2C2_2	457..481	CDD:290200	11/23 (48%)
		C2H2 Zn finger	472..493	CDD:275368	7/20 (35%)
ZNF251	NP_612376.1	KRAB	15..75	CDD:214630	9/48 (19%)
		C2H2 Zn finger	181..203	CDD:275368	1/21 (5%)
		COG5048	207..635	CDD:227381	121/518 (23%)
		C2H2 Zn finger	211..231	CDD:275368	3/33 (9%)
		C2H2 Zn finger	239..259	CDD:275368	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	11/26 (42%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
		C2H2 Zn finger	435..455	CDD:275368	7/20 (35%)
		C2H2 Zn finger	463..483	CDD:275368	3/19 (16%)
		C2H2 Zn finger	491..511	CDD:275368	2/19 (11%)
		C2H2 Zn finger	568..588	CDD:275368	3/19 (16%)
		C2H2 Zn finger	596..616	CDD:275368	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910