DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wdn and ZNF34

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens

Alignment Length:	372	Identity:	112/372 - (30%)
Similarity:	154/372 - (41%)	Gaps:	80/372 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 KVFKEEPPEEKHPPEQV--VTKVEVCESELL----PPSFTIFQQAKSAESVAD--AASMPPPAAS 256
            :.|.||.|:...|.|..  ::|.|....:|:    |.:.|:.....|.||..:  ..|.|.|
Human   129 ETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGGNLRLLSRPVP--- 190

  Fly   257 ETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLT----------------------- 298
                   |..| |||..|. ...|....:..|: ..||.:.|
Human   191 -------DQRP-HKCDICE-QSFEQRSYLNNHK-RVHRSKKTNTVRNSGEIFSANLVVKEDQKIP 245

  Fly   299 -----YRCSECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWM-HRKIHSDNKK 357
                 :.||.|.:.|...|.|.||.:.| ||.:.   .||.:|||.......:: ||::||....
Human   246 TGKKLHYCSYCGKTFRYSANLVKHQRLH-TEEKP---YKCDECGKAFSQSCEFINHRRMHSGEIP 306

  Fly   358 YQCDICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKM 422
            |:||.||:.|.::.||..|.|||:.||||:|.||.|.|...|.|..||:.|...:.|:|..|||.
Human   307 YRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTGEKPYKCNDCGKA 371

  Fly   423 YKTERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLK 487
            :.....|..|...|..::||.|..|.|.|..:|.|.||..||||.:|:|||.|.:.|......::
Human   372 FSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVE 436

  Fly   488 HTRRR-------------------HKVDHK---TGEHLENIPSYCSK 512
            |.|..                   |.:.|:   |||.    |..||:
Human   437 HQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTGEK----PYKCSE 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		RPB9	333..425	CDD:224510	39/92 (42%)
		C2H2 Zn finger	333..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..369	CDD:290200	10/25 (40%)
		zf-C2H2	358..380	CDD:278523	10/21 (48%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		zf-H2C2_2	372..395	CDD:290200	14/22 (64%)
		zf-C2H2	386..408	CDD:278523	10/21 (48%)
		C2H2 Zn finger	388..436	CDD:275368	17/47 (36%)
		zf-H2C2_2	400..425	CDD:290200	9/24 (38%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	9/23 (39%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	457..481	CDD:290200	13/23 (57%)
		C2H2 Zn finger	472..493	CDD:275368	6/39 (15%)
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630
		KRAB	35..74	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		6/24 (25%)
		COG5048	188..554	CDD:227381	97/313 (31%)
		C2H2 Zn finger	197..217	CDD:275368	4/21 (19%)
		zf-C2H2	251..273	CDD:278523	8/21 (38%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	265..290	CDD:290200	11/28 (39%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-C2H2	307..329	CDD:278523	10/21 (48%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		zf-H2C2_2	321..345	CDD:290200	14/23 (61%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	349..373	CDD:290200	9/23 (39%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		zf-H2C2_2	378..402	CDD:290200	9/23 (39%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..430	CDD:290200	13/24 (54%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..458	CDD:290200	2/23 (9%)
		C2H2 Zn finger	449..469	CDD:275368	2/19 (11%)
		zf-H2C2_2	461..486	CDD:290200	8/23 (35%)
		C2H2 Zn finger	477..497	CDD:275368	2/3 (67%)
		zf-H2C2_2	493..514	CDD:290200
		C2H2 Zn finger	505..525	CDD:275368
		zf-H2C2_2	517..542	CDD:290200
		C2H2 Zn finger	533..553	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910