DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wdn and Zfp626

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_081979.1	Gene:	Zfp626 / 71163	MGIID:	1918413	Length:	676	Species:	Mus musculus

Alignment Length:	516	Identity:	136/516 - (26%)
Similarity:	207/516 - (40%)	Gaps:	113/516 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 QQAKSAESVADAASMPP-----PAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRL 295
            |:..:.:.|.....:||     .|.|..||.|....  .||.:|:..|       ::|: :.|..
Mouse   143 QEGDAGQQVTKKEGVPPYTCQTLAHSLQKPYECKQC--GKCFNCSSTL-------SQHQ-SVHAG 197

  Fly   296 RLTYRCSECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWM-HRKIHSDNKKYQ 359
            ...|.|.|..:.|.|...|.:|.|:|.:|...:    |.:|||...|..:.. |:..|:..|.::
Mouse   198 EKPYECKEYGKVFRLPQQLTRHQKSHSSEKPFE----CNECGKAFHLPHLLQNHKTTHTGTKAFE 258

  Fly   360 CDICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYK 424
            |:.||:.|.:..||..|..||:..|||:|.||.|.|:.||:..:|||.|:..|.::|::|||.:.
Mouse   259 CEECGKIFNRVSNLVAHRIIHADVKPYKCNECGKAFKRRSYYMQHQKIHSGERPFQCKECGKAFI 323

  Fly   425 TERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHT 489
            ....|..|.::|..::.|||..|.|:|....:|.:|...|:|.||||||.|.:.|. ||:.||.
Mouse   324 FLAHLNGHQMIHTGEKSFACKECGKAFRLLQQLTRHQKFHSGDRPFKCNECGKAFP-FPDRLKL- 386

  Fly   490 RRRHKVDHKTGEHLENIPSYCSKKSTTNKAQKAAAAAAAAAAASSAVNPNELS-ASSELKAKANL 553
                   ||| .|....|..|.:   ..|:.|..:..|......:.|.|.|.| .......::||
Mouse   387 -------HKT-IHTNTKPFECRE---CGKSFKCVSHLAQHRIIHADVKPYECSECGKAFNRRSNL 440

  Fly   554 TSTAAPAPAKQARKKKQPQQATLAALGIT-LPAGTALQQVH----PV------------PLAQQH 601
            ..      .::....::|.:........| ||..|..|::|    |.            |...||
Mouse   441 IQ------HQKIHSGEKPFECKDCGKAFTVLPQLTRHQRIHTGEKPFECKECGKKFYTGPHLAQH 499

  Fly   602 QQELTTVLVPLAPPAPKQT----KAKRERKQLAPKQ---LQQKP----------------QLLQQ 643
            |:..|       ...|.:.    ||.|.|..|:..|   :::||                .|.:|
Mouse   500 QRVHT-------GEKPFECNVCGKAFRLRACLSEHQKTHIEEKPFKCKLCGSAFRSRYQLSLHRQ 557

  Fly   644 GQP-------QQSSLEPIPAVPQIKKEPVQTQGPFLDLHGLSLTSAEELIMEQALEMEECG 697
            ..|       |:.....|.....|:.:.|.|.                   |::.|.:|||
Mouse   558 THPHVRPFQCQECGKAYILLAQLIQHQTVHTG-------------------ERSFECKECG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		RPB9	333..425	CDD:224510	36/92 (39%)
		C2H2 Zn finger	333..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..369	CDD:290200	7/25 (28%)
		zf-C2H2	358..380	CDD:278523	7/21 (33%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		zf-H2C2_2	372..395	CDD:290200	12/22 (55%)
		zf-C2H2	386..408	CDD:278523	11/21 (52%)
		C2H2 Zn finger	388..436	CDD:275368	18/47 (38%)
		zf-H2C2_2	400..425	CDD:290200	9/24 (38%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	9/23 (39%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..481	CDD:290200	12/23 (52%)
		C2H2 Zn finger	472..493	CDD:275368	8/20 (40%)
Zfp626	NP_081979.1	KRAB	14..75	CDD:214630
		COG5048	170..572	CDD:227381	121/441 (27%)
		C2H2 Zn finger	175..195	CDD:275368	5/29 (17%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	10/19 (53%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	11/29 (38%)
		C2H2 Zn finger	399..419	CDD:275368	4/22 (18%)
		C2H2 Zn finger	427..447	CDD:275368	3/25 (12%)
		C2H2 Zn finger	455..475	CDD:275368	5/19 (26%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..559	CDD:275368	2/19 (11%)
		C2H2 Zn finger	567..587	CDD:275368	3/19 (16%)
		C2H2 Zn finger	595..615	CDD:275368	3/5 (60%)
		zf-H2C2_2	607..631	CDD:372612
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	651..671	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4021
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950