Protein Alignment wdn and PRDM10

DIOPT Version :10

• Sequence 1: NP_476900.1
• Gene: wdn / 43398
• FlyBaseID: FBgn0005642
• Length: 869
• Species: Drosophila melanogaster
• Sequence 2: NP_064613.2
• Gene: PRDM10 / 56980
• HGNCID: 13995
• Length: 1160
• Species: Homo sapiens
• Alignment Length: 933
• Identity: 203/933 - (21%)
• Similarity: 319/933 - (34%)
• Gaps: 255/933 - (27%)

  Fly    57 KDESLDIDLSACVTISSASLVNGNSLSSTDFWRVLDESAQNNTELNL--------------SSDV 107
            |:..|..||  ...:|..:|.|         |.:....|||:.|.||              .:..
Human   263 KERDLHEDL--WFELSDETLCN---------WMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVE 316

  Fly   108 CRDDLAATSSSTVPSTLTSDNHSSSEFSVTFLRPEPPN---AFTNSPFKKTSSSGTSTPVKLSPE 169
            .:.:|....:::....:....|..||.....||.:..|   ...|..|             :|.|
Human   317 PKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWPCYECNRRF-------------ISSE 368

  Fly   170 QLHQQHQLQMPQSQL-------------------LQRKPKLPAATAVRLKVFKEEPPEEKHPPEQ 215
            || ||| |.....:|                   ..|:|..| ...:||::..|...:.....:.
Human   369 QL-QQH-LNSHDEKLDVFSRTRGRGRGRGKRRFGPGRRPGRP-PKFIRLEITSENGEKSDDGTQD 430

  Fly   216 VV---TKVEVCESELLPPSFTIFQQAKSAESVADAASMPPPAAS------ETKPLEVDPAPLHKC 271
            ::   ||.:..|:|  |.:.....|.:  ::......:|....|      ||..|.:.|......
Human   431 LLHFPTKEQFDEAE--PATLNGLDQPE--QTTIPIPQLPQETQSSLEHEPETHTLHLQPQHEESV 491

  Fly   272 LDCNGLLLETPDEVAKHEAAAHRLRL-----------------TYRCSECQREFELLAGLKKHLK 319
            :.....|  |.|::.:    |.|:||                 .::|.:|.:.|.....|.:||:
Human   492 VPTQSTL--TADDMRR----AKRIRLELQNAALQHLFIRKSFRPFKCLQCGKAFREKDKLDQHLR 550

  Fly   320 THRTEGRKDTWKKCP-DCGKC----LKLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARI 379
            .|..||      .|| .|..|    :...|:..|.|:|||.|.|.|..|.:.|.:...|..|..|
Human   551 FHGREG------NCPLTCDLCNKGFISSTSLESHMKLHSDQKTYSCIFCPESFDRLDLLKDHVAI 609

  Fly   380 HSSEKPYECPECQKRFQERSHLQRH-QKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFA 443
            |.::..:.||.|:|||.:...:::| :.:|:: :.|:|.:|.|.:.....|::|.|.|.:::.|.
Human   610 HINDGYFTCPTCKKRFPDFIQVKKHVRSFHSE-KIYQCTECDKAFCRPDKLRLHMLRHSDRKDFL 673

  Fly   444 CTVCDKSFISNSKLKQH-SNIHTGMR--------------------------PFKCNYCPRDFTN 481
            |:.|.|.|....||::| ..:|...|                          .|||..|...|..
Human   674 CSTCGKQFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRITSTDYDSFTFKCRLCMMGFRR 738

  Fly   482 FPNWLKHTRRRHKVDHKTGEHLENIP---------------SYCSKKSTTNKAQKA-------AA 524
            ....:.|..:||. |.|    :|.:|               .||.|...:...:||       .|
Human   739 RGMLVNHLSKRHP-DMK----IEEVPELTLPIIKPNRDYFCQYCDKVYKSASKRKAHILKNHPGA 798

  Fly   525 AAAAAAAASSAVNPNELSASSELKAKANLTSTAAPAP------AKQAR---------KKKQPQQA 574
            ....:........|.|  ....|.....||.|.|..|      :||..         :||.|:.|
Human   799 ELPPSIRKLRPAGPGE--PDPMLSTHTQLTGTIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEFA 861

  Fly   575 TLAALGITLPAGTALQQVHPVPLAQQH---QQELTTVLVPLAPPAPKQT--------KAKRERKQ 628
            .|:.. |..|..||:....|..|....   :..:||.|:..|.....||        :...:|.|
Human   862 QLSNT-IHTPLTTAVISATPAVLTTDSATGETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQ 925

  Fly   629 LAPKQLQ----QKPQLLQ-----------QGQPQQSSL------EPIPAVPQ--IKKEPVQTQGP 670
            ..|....    |:||.:|           ..|.|||::      :|.| .||  |:.:.:|...|
Human   926 YIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQP-YPQHAIQVQHIQVSEP 989

  Fly   671 FLDLHGLSLTSAEELIMEQALEMEECGLYDAPNA-NTEMGTSDNAISDSAA----ALHFQIKNEL 730
            .......:..|.:.|               :|:| ..:.|.|.:.|..|::    ||..|.:.:.
Human   990 TASAPSSAQVSGQPL---------------SPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQ 1039

  Fly   731 PDELLPDDDFLPCK------PSDRLPCPSLESSPFSSPASMELTAVSCASSVAISTNALPVRSGN 789
            ...:  ...:||..      .|..:...:|....|....|...|.|:.....|::       ||:
Human  1040 NSSV--QHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVT-------SGH 1095

  Fly   790 YYLPAFTLNAHGK-LSSTGNGVQ 811
            |.|.........| .|:...|||
Human  1096 YVLSESQSELEEKQTSALSGGVQ 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	zf-C2HE	<279..321	CDD:465082	12/58 (21%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	333..352	CDD:275368	7/23 (30%)
		zf-C2H2	358..380	CDD:395048	6/21 (29%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	376..395	CDD:463886	7/18 (39%)
		zf-C2H2	386..408	CDD:395048	7/22 (32%)
		C2H2 Zn finger	388..436	CDD:275368	15/48 (31%)
		zf-H2C2_2	400..425	CDD:463886	6/25 (24%)
		C2H2 Zn finger	416..433	CDD:275368	4/16 (25%)
		SUF4-like	440..>507	CDD:411020	21/93 (23%)
		C2H2 Zn finger	444..465	CDD:411020	7/21 (33%)
		C2H2 Zn finger	444..464	CDD:275368	7/20 (35%)
		zf-H2C2_2	457..481	CDD:463886	9/50 (18%)
		C2H2 Zn finger	472..493	CDD:411020	4/20 (20%)
		C2H2 Zn finger	472..493	CDD:275368	4/20 (20%)
PRDM10	NP_064613.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..168
		zf_PR_Knuckle	<173..200	CDD:375871
		PR-SET_PRDM10	203..334	CDD:380971	15/81 (19%)
		N-terminal PR domain, essential for transcriptional activator activity. /evidence=ECO:0000250|UniProtKB:Q3UTQ7	227..331		15/78 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..412		3/25 (12%)
		Tristanin_u2	405..510	CDD:465211	22/115 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..499		6/34 (18%)
		C2H2 Zn finger	532..552	CDD:275368	6/19 (32%)
		COG5048	<559..692	CDD:227381	42/133 (32%)
		C2H2 Zn finger	562..582	CDD:275368	5/19 (26%)
		C2H2 Zn finger	590..610	CDD:275368	5/19 (26%)
		C2H2 Zn finger	618..638	CDD:275368	7/19 (37%)
		zf-C2H2	644..666	CDD:395048	7/21 (33%)
		C2H2 Zn finger	646..666	CDD:275368	6/19 (32%)
		C2H2 Zn finger	674..695	CDD:275368	7/20 (35%)
		C2H2 Zn finger	729..755	CDD:275368	8/30 (27%)
		C2H2 Zn finger	774..791	CDD:275368	5/16 (31%)
		SP1-4_N	<844..>1018	CDD:425404	41/190 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	953..973		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1001..1044		10/59 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1101..1160		5/18 (28%)