DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdn and si:dkeyp-113d7.1

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_999959.1	Gene:	si:dkeyp-113d7.1 / 407709	ZFINID:	ZDB-GENE-030131-755	Length:	498	Species:	Danio rerio

Alignment Length:	584	Identity:	145/584 - (24%)
Similarity:	226/584 - (38%)	Gaps:	153/584 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DAGTPTKAAHDEILSSLLRINNFDSISS-----------IKDE-SLD----IDLSACVTISSASL 76
            |.||||..    :|||........|::|           ||.| .||    :|||....:|:|.|
Zfish    31 DCGTPTLT----MLSSECSTPTLSSLASEIVEPMAMLPCIKSEPDLDPIRTVDLSVIQPLSTAEL 91

  Fly    77 VNGN---SLSSTDFWRV---LDESAQNNTEL-----NLSSDVCRDDLAATSSST--VPSTLTSDN 128
            .:..   .:|..|:.:.   .|..:.::|||     :....:..|.::..|.|.  :.|...||.
Zfish    92 GSDQIKMEISGLDYIKSEHHSDLHSFHSTELGSYKSHYEPSLVFDYISHVSDSLEYIKSEHHSDL 156

  Fly   129 HS--SSEFSVTFLRPEPPNAFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMPQSQLLQRKPKL 191
            ||  :||........||  .|..|.. ||..:|.        |.:|           :.:.:.:|
Zfish   157 HSYYASELGTIKTEYEP--IFMTSHI-KTEMNGL--------ESIH-----------MAELRTEL 199

  Fly   192 PAATAVRLKVFKEEPPEEKHPPEQVVTKVEVCESELLPPSFTIFQQAKSAESVADAASMPPPAAS 256
                             :|..||.::..:...:|:.  .|.::::......:.|.||..|
Zfish   200 -----------------DKLRPETLIDGIGKLDSDF--SSNSLYELTSVHANKAQAAHHP----- 240

  Fly   257 ETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQREFELLAGLKKHLKTH 321
             |......|.| .|..:..|   |.|                :.|::|.:.|..|..||.|.:.|
Zfish   241 -TSTKGHGPTP-RKPRNPTG---EKP----------------FSCTQCGKNFSTLGNLKTHKRIH 284

  Fly   322 RTEGRKDTWKKCPDCGKCL-KLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKP 385
            ..| |..|   |..|||.. :.|::..|:.||:..|.|.|..|.:.|.:..:|..|.|:|:.|||
Zfish   285 TGE-RPYT---CSQCGKSFGQAGNLKRHQLIHTGQKPYTCAHCPKGFTKADDLRSHQRLHTGEKP 345

  Fly   386 YECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFACTVCDKS 450
            :.|.||.|.|.:...|:.||..|...|.:.|..|||.:..|...:.|..:|:.::|::|:.|.||
Zfish   346 FSCAECGKSFSQTKELKAHQLSHTGERPFCCSLCGKSFSKETSYRNHQQIHMGEKPYSCSQCGKS 410

  Fly   451 FISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGEHLENIPSYCSKKST 515
            |.::..||.|..||:|.|||.|..|.:.|..    |.|.:...::  .|||.    |..|.:..
Zfish   411 FSNSGVLKTHEKIHSGERPFGCTQCGKHFGR----LGHLKAHQQI--HTGER----PYTCQQCG- 464

  Fly   516 TNKAQKAAAAAAAAAAASSAVNPNELSASSELKAKANLTSTAAPAPAKQARKKKQPQQATLAAL 579
                                   ...|.|..|||.            :|..|:::|..::.::|
Zfish   465 -----------------------KNFSQSGHLKAH------------EQIHKRERPDLSSGSSL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		RPB9	333..425	CDD:224510	34/92 (37%)
		C2H2 Zn finger	333..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..369	CDD:290200	8/24 (33%)
		zf-C2H2	358..380	CDD:278523	7/21 (33%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..395	CDD:290200	11/22 (50%)
		zf-C2H2	386..408	CDD:278523	8/21 (38%)
		C2H2 Zn finger	388..436	CDD:275368	16/47 (34%)
		zf-H2C2_2	400..425	CDD:290200	9/24 (38%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	8/23 (35%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	457..481	CDD:290200	12/23 (52%)
		C2H2 Zn finger	472..493	CDD:275368	5/20 (25%)
si:dkeyp-113d7.1	NP_999959.1	COG5048	<260..414	CDD:227381	55/173 (32%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	276..299	CDD:290200	11/26 (42%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		zf-H2C2_2	304..328	CDD:290200	7/23 (30%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		zf-H2C2_2	332..357	CDD:290200	12/24 (50%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		zf-H2C2_2	360..384	CDD:290200	9/23 (39%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	388..413	CDD:290200	8/24 (33%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	5/25 (20%)
		zf-H2C2_2	444..469	CDD:290200	6/54 (11%)
		C2H2 Zn finger	460..480	CDD:275368	7/55 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100