DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdn and Phs

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_648789.3	Gene:	Phs / 39697	FlyBaseID:	FBgn0036522	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	169/732 - (23%)
Similarity:	273/732 - (37%)	Gaps:	190/732 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PSKKLPPKIYGGDAGTPTKAAHDEILSSLLRINNFDSISSIKDESLDIDLSACVTISSASLVN-- 78
            |:.:.||....|....|:.|::|:  ..|..||  |.::.|..|.        |..:|:|.||
  Fly   294 PAPETPPPEQDGKEAPPSNASNDK--EDLTMIN--DMVAVIAAER--------VKKTSSSKVNKM 346

  Fly    79 ----------GNSLSSTDFWRVLDESAQNNTE--------------------LNLSSDVCRDDLA 113
                      |...:..:..|  ||  |:|.|                    |.......:.:..
  Fly   347 IIKLPMPKKRGRKRTKPESLR--DE--QDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENG 407

  Fly   114 ATSSSTVPSTLTS------DNHSSSEFSVTFLRPEP-PNAFTNS-------PFKKT--------- 155
            ||.|:.|.....:      |...|::.|.|  .|:. .||.|||       ..|:|
  Fly   408 ATQSNNVVKVQQNAKGSKKDGTQSAQKSET--NPKHLENAETNSKDNTESVALKETIHDKQLTID 470

  Fly   156 ----------------------SSSGTSTPVKLSPEQLHQQ--------HQLQMPQSQL------ 184
                                  :::|.|..|    :|:|||        || ||.:...
  Fly   471 EAGKAGTQKDDNSNQKQLDKSEANAGKSKMV----DQVHQQMPVESAKDHQ-QMTEEPTNSTKRK 530

  Fly   185 ---LQRKPKLPAATAVRLKVFKEEP--PEE--KHPPEQVVTKVEVCESELLPPSFTIFQQAKSAE 242
               .:||...|....:..|..||||  ||.  :...:.|...||:.:.|      ....:.:.||
  Fly   531 RGRKERKSPTPVLIPLGDKEIKEEPELPERRMRKSRQHVDYVVEIKDEE------EDDDEVEEAE 589

  Fly   243 SVADAASMPPPAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQRE 307
            ...|:::...|..|.|..            ....:..|:.:| ::|.....    .:.|:.|.:.
  Fly   590 VDDDSSATISPHNSSTDE------------SFTSIKRESSEE-SQHNGIGG----IHTCNFCGKT 637

  Fly   308 FELLAGLKKHLKTHRTEGRKDTWKK---CPDCGKCLKLGSMWM-HRKIHSDNKKYQCDICGQKFV 368
            |:..:.::.||:.|       |.:|   |..||:..:|....: |:..|...|.|:||||.....
  Fly   638 FKRFSRMQDHLRLH-------TGEKPYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLA 695

  Fly   369 QKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHN 433
            .|.:|:.|.|.|.:::.|:|.:|.|.|...|.|..|.:.|...:.|.|:.|||.::..:.|.||.
  Fly   696 TKQDLSLHMRHHKNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHR 760

  Fly   434 LVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHK 498
            ..||..:|..|.:|||.|.....::.|...|||.:|:.|:.|.|.:::..|.|:|..|.|.::
  Fly   761 RTHLGDKPIQCELCDKRFARKIDMRVHMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHGIE-- 823

  Fly   499 TGEHLENIP------SYCSKKSTTNKAQKAAAAAAAAAAASSAVNPNELSASSELKAKANLTSTA 557
                 |.:|      ...:|.:|.|:.:....|.||...........:::|..:|......:.:|
  Fly   824 -----EQVPGSGQADKKHTKTATENEQENEPKAKAAPRRPRREKLQQKIAAQEKLLNDLKRSLSA 883

  Fly   558 AP-APAKQARKKKQPQQATLAALGITLPAG----------TALQQVHPVPLAQQHQQELTTV--- 608
            .| .|.:.|       |..|...|..:||.          |...|:.|.|..:. .:|:|..
  Fly   884 MPEIPEESA-------QVKLDGSGQDIPADAGAGHAQVQVTLSMQMEPAPNTED-DEEITPEKEN 940

  Fly   609 LVPLAPPAPKQTKAKRE 625
            .:..:..|..:|||.|:
  Fly   941 ALSSSMTADGKTKANRK 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		RPB9	333..425	CDD:224510	31/92 (34%)
		C2H2 Zn finger	333..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	344..369	CDD:290200	8/25 (32%)
		zf-C2H2	358..380	CDD:278523	9/21 (43%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..395	CDD:290200	8/22 (36%)
		zf-C2H2	386..408	CDD:278523	8/21 (38%)
		C2H2 Zn finger	388..436	CDD:275368	16/47 (34%)
		zf-H2C2_2	400..425	CDD:290200	8/24 (33%)
		C2H2 Zn finger	416..433	CDD:275368	6/16 (38%)
		zf-H2C2_2	429..453	CDD:290200	11/23 (48%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..481	CDD:290200	8/23 (35%)
		C2H2 Zn finger	472..493	CDD:275368	7/20 (35%)
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	56/216 (26%)
		C2H2 Zn finger	631..651	CDD:275368	5/19 (26%)
		zf-H2C2_2	644..666	CDD:290200	8/28 (29%)
		zf-H2C2_2	699..724	CDD:290200	9/24 (38%)
		zf-C2H2	713..735	CDD:278523	8/21 (38%)
		C2H2 Zn finger	715..735	CDD:275368	7/19 (37%)
		zf-H2C2_2	727..750	CDD:290200	8/22 (36%)
		C2H2 Zn finger	743..763	CDD:275368	7/19 (37%)
		zf-H2C2_2	755..780	CDD:290200	11/24 (46%)
		C2H2 Zn finger	771..791	CDD:275368	6/19 (32%)
		zf-H2C2_2	783..808	CDD:290200	8/24 (33%)
		C2H2 Zn finger	799..816	CDD:275370	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100