DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wdn and Zfp251

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_001178840.1	Gene:	Zfp251 / 366954	RGDID:	1311138	Length:	633	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	123/458 - (26%)
Similarity:	188/458 - (41%)	Gaps:	80/458 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 ELNLSSDVCRDDLAATSSSTVPS---TLTSDNHSSSEFSV-TFLRPEPPNAFTNSPFKKTSSSGT 160
            |..|..||..::....:|...|.   .|.|......|..| ..|..|.|...        .|.||
  Rat    36 ERALYRDVMLENYGNVASLGFPGPKPELISQLEQEEELWVLDLLGAEEPEVL--------RSCGT 92

  Fly   161 STPVKLSPEQ--LHQQHQLQMPQSQLLQRKPKLPAATAVRLKVFKEEPPEEKHPPEQV------V 217
            .:.:|...|:  |:|:...::...:|.|:.|:..:..:...:....|...:.......      |
  Rat    93 DSEIKSEKERSILNQKCSEEVKTPELSQKFPRANSQASESKEACAHESQGDGSQGSSATQGLKGV 157

  Fly   218 TKVE--VCESELLPPSFTIFQQAKSAESVADAASMPPPAASETKPLEVDPAPLHKCLDCNGLLLE 280
            .|.:  ||...|  |..|   ||.||..    ..:.|..:..|.........:.||..||.:...
  Rat   158 AKKDSTVCREHL--PENT---QASSAFD----KHLNPSQSGVTIQRNKTGQRIFKCDICNKMFKY 213

  Fly   281 TPDEVAKH----------------EAAAHRLRL-----------TYRCSECQREFELLAGLKKHL 318
            ..| :::|                .|..|...|           .::|.||.:.|    ||..:|
  Rat   214 NSD-LSRHRRSHTGEKPYECGPCGRAFTHSSNLILHQRIHTGNKPFKCDECGKTF----GLNSYL 273

  Fly   319 KTHRTEGRKDTWKK---CPDCGKCL-KLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARI 379
            :.|:   |..|.:|   |.:|||.. :..|:..||.||:..|.|:|:.||:.|.|...||.|.||
  Rat   274 RLHQ---RIHTGEKPFGCNECGKAFSRSSSLIQHRIIHTGEKPYKCNECGKAFSQSPQLTQHQRI 335

  Fly   380 HSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFAC 444
            |:.|||:.|..|.|.|...:.|.:||:.|...:.::|.:|||.:.....|.:|:.||..::|:.|
  Rat   336 HTGEKPHGCSWCGKAFSRNASLIQHQRIHTGEKPHKCTQCGKAFSQSSSLFLHHRVHTGEKPYVC 400

  Fly   445 TVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGEHLENIPSY 509
            ..|.::|..||.|.:|..||||.:|:.|..|.:.|:.....::| ||.|     |||.    |..
  Rat   401 GECGRAFGFNSHLTEHVRIHTGEKPYVCGECGKAFSRSSTLMQH-RRVH-----TGEK----PYQ 455

  Fly   510 CSK 512
            |::
  Rat   456 CAE 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		RPB9	333..425	CDD:224510	37/92 (40%)
		C2H2 Zn finger	333..352	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..369	CDD:290200	11/24 (46%)
		zf-C2H2	358..380	CDD:278523	10/21 (48%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		zf-H2C2_2	372..395	CDD:290200	12/22 (55%)
		zf-C2H2	386..408	CDD:278523	7/21 (33%)
		C2H2 Zn finger	388..436	CDD:275368	14/47 (30%)
		zf-H2C2_2	400..425	CDD:290200	8/24 (33%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	8/23 (35%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		zf-H2C2_2	457..481	CDD:290200	10/23 (43%)
		C2H2 Zn finger	472..493	CDD:275368	6/20 (30%)
Zfp251	NP_001178840.1	KRAB	15..75	CDD:214630	9/38 (24%)
		KRAB	15..54	CDD:279668	4/17 (24%)
		COG5048	82..467	CDD:227381	112/412 (27%)
		zf-C2H2	202..224	CDD:278523	6/22 (27%)
		C2H2 Zn finger	204..224	CDD:275368	5/20 (25%)
		zf-H2C2_2	216..241	CDD:290200	3/25 (12%)
		C2H2 Zn finger	232..252	CDD:275368	3/19 (16%)
		zf-H2C2_2	244..267	CDD:290200	4/22 (18%)
		C2H2 Zn finger	260..280	CDD:275368	9/26 (35%)
		zf-H2C2_2	272..297	CDD:290200	9/27 (33%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		zf-H2C2_2	300..325	CDD:290200	11/24 (46%)
		C2H2 Zn finger	316..336	CDD:275368	9/19 (47%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		zf-H2C2_2	356..381	CDD:290200	8/24 (33%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..407	CDD:290200	7/22 (32%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		zf-H2C2_2	412..437	CDD:290200	10/24 (42%)
		C2H2 Zn finger	428..448	CDD:275368	6/20 (30%)
		zf-H2C2_2	441..465	CDD:290200	9/28 (32%)
		C2H2 Zn finger	456..476	CDD:275368	1/3 (33%)
		zf-H2C2_2	469..493	CDD:290200
		C2H2 Zn finger	484..504	CDD:275368
		C2H2 Zn finger	557..577	CDD:275368
		C2H2 Zn finger	585..602	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910