DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdn and wor

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	465	Identity:	99/465 - (21%)
Similarity:	177/465 - (38%)	Gaps:	98/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ESAQNNTELNLSSDVCRDDLAATSSSTVPSTLTSDNHSSS-------EFSV----TFLRPEP-PN 145
            ::|.|.|:..|:..:..:  ....:...|...|.:..:.|       ||.:    ..:.||| |.
  Fly    69 DAAMNQTKEQLARRIWEE--TREIARAFPDVFTREEIAKSLARLGYGEFELPPEEEVMEPEPEPE 131

  Fly   146 AFTNSPFKKTSSSGTSTPVKLSPEQLHQQHQLQMPQSQLLQRKPKLPAATAVRLKVFKEE----- 205
              .:.|.:.|..: :.|.:|..|.. .:|..|:...:.||  |........::::..|||
  Fly   132 --QHLPLRYTRDA-SPTIIKAEPSD-EEQFPLRNYNNNLL--KSIAEYEDCMKMQNIKEEIPPIP 190

  Fly   206 PPEEKHPPEQVVTKVE---VCESELLPPSFTIFQQAKSAESVADAASM--PPPAASETKPLEVDP 265
            .|:..:||...:.:.|   |.:..:|..:..:...|::..|:...|..  |||         :|.
  Fly   191 SPQLFYPPPTPLAEPEDLSVTQRRVLSENMNLQNVARALLSMQHMAPQHAPPP---------IDM 246

  Fly   266 APLHKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQREFELLAGLKKHLKTHRTEGRK--- 327
            ....:..|.|.|.:::.::            |.|:|.:|.:.:...|||.||.:||..|..:
  Fly   247 EEDQENQDINQLKIKSSND------------LYYQCQQCNKCYATYAGLVKHQQTHAYESTEYKI 299

  Fly   328 ------------DTWKKCPDCGKCLKLGSMWMHRKIHSDN-------------KKYQCDICGQKF 367
                        |..:.|.|....|          |.:.|             .:|.|..||:.:
  Fly   300 IRSQPGGSGAIVDQTEFCTDQASAL----------IQAANVASAQSMQKPVGVPRYHCQDCGKSY 354

  Fly   368 VQKINLTHHARIH--SSE-----KPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKT 425
            .....|:.|.:.|  |:|     |.:.|..|.|.:.....|:.|.:.|  |...:|..|||.:..
  Fly   355 STYSGLSKHQQFHCPSAEGNQVKKVFSCKNCDKTYVSLGALKMHIRTH--TLPCKCPICGKAFSR 417

  Fly   426 ERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTR 490
            ...|:.|...|..::||:|..|:::|...|.|:.|...|:.::.:.|..|.:.|:......||.:
  Fly   418 PWLLQGHIRTHTGEKPFSCQHCNRAFADRSNLRAHMQTHSDVKKYSCPTCTKSFSRMSLLAKHLQ 482

  Fly   491 RRHKVDHKTG 500
            ...:.:...|
  Fly   483 SGCQTEQSGG 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		RPB9	333..425	CDD:224510	26/111 (23%)
		C2H2 Zn finger	333..352	CDD:275368	3/18 (17%)
		zf-H2C2_2	344..369	CDD:290200	6/37 (16%)
		zf-C2H2	358..380	CDD:278523	6/21 (29%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	372..395	CDD:290200	9/29 (31%)
		zf-C2H2	386..408	CDD:278523	5/21 (24%)
		C2H2 Zn finger	388..436	CDD:275368	13/47 (28%)
		zf-H2C2_2	400..425	CDD:290200	8/24 (33%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	8/23 (35%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..481	CDD:290200	6/23 (26%)
		C2H2 Zn finger	472..493	CDD:275368	5/20 (25%)
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		C2H2 Zn finger	317..334	CDD:275368	5/26 (19%)
		zf-C2H2	345..367	CDD:278523	6/21 (29%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		PHA00732	379..>417	CDD:177300	11/39 (28%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		zf-C2H2_8	405..482	CDD:292531	21/76 (28%)
		zf-C2H2	406..428	CDD:278523	6/21 (29%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		zf-H2C2_2	421..444	CDD:290200	7/22 (32%)
		zf-C2H2	434..456	CDD:278523	7/21 (33%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		zf-H2C2_2	448..473	CDD:290200	6/24 (25%)
		C2H2 Zn finger	464..481	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930