DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdn and znf-782

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	165/782 - (21%)
Similarity:	242/782 - (30%)	Gaps:	277/782 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 PEEKHPPEQVVTKVEVCESELLPPSFTIFQQAKSAESVADAASMPPPAASETKPLEVDPAPLHKC 271
            |::.|..:....:.|..|.|||.......::.:..|: :|:||....|.|.           |..
Worm    16 PDDIHMKDPEEEEFEEYEDELLEEEEEFDEELEELEN-SDSASSLVSAGSP-----------HGS 68

  Fly   272 LDCNG-------LLLETPDEVAKHEAAAHRLRLTYRCSECQREFELLAGLKKHLKTHRTEGRKDT 329
            ...||       |.:::|.:.:....:          ...|.|       |:|:
Worm    69 SSSNGSHGSSPPLQVQSPSQGSGSSGS----------PTGQPE-------KRHI----------- 105

  Fly   330 WKKCPDCGKCLKLGS-MWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKPYECPECQK 393
               |..|||.....| :..|::.|:..|.|.|..|.:.|.||..|..|.|.|:.|:||:|..|:|
Worm   106 ---CTVCGKGFSYFSILESHKRSHTGEKPYNCHFCQKTFAQKATLQVHERTHTGERPYKCRYCEK 167

  Fly   394 RFQERSHLQRHQK-YHAQTRSYRCEKCGKMY---------------KTERC-------------- 428
            .|.:......|:| .|...|:|:|.||.|:.               ||.||
Worm   168 TFAQYGTKTVHEKSAHLGIRNYKCPKCDKLLSSPSALYTHKKTHGDKTFRCDFCPKTFALKNYLK 232

  Fly   429 ----------------------------LKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHT 465
                                        |:||...|..:||:.|..|.|:|.|...|:.|...||
Worm   233 LHVKQVHEQNERKHVCVYCNKGFAYAGSLQVHVRTHTGERPYVCKFCPKAFASQGNLQSHERTHT 297

  Fly   466 GMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGEHLEN--------IP--------------- 507
            |.||:.|.:|.|.|..     |.....|:..|.|.:|..|        :|
Worm   298 GERPYSCQFCQRTFIQ-----KSQLTAHESTHLTQKHSVNPDSTTADILPVAGSVTDHQMVGNYE 357

  Fly   508 -SYCSKK---------STTNKAQKAAAAAAAAAAASSAVNPNELSASSELKAKANLTSTAAPAPA 562
             ::|:||         ......:|:|.:........|.            |...|:......|..
Worm   358 CTFCNKKYPYASSLYIHMRKHTEKSAYSCDGCGKPYSQ------------KISLNIHQDQCEAFK 410

  Fly   563 KQARKKKQPQQATLAALGITLPAGTALQQVHPVPLAQQHQQELTTVLVPLAPPAPKQTKAKRERK 627
            .:.:.............|.:.....|| |:| |...:.|                         |
Worm   411 NRLKTTDSQFSHNCDGCGKSFVQRIAL-QIH-VDSCEPH-------------------------K 448

  Fly   628 QLAPKQLQQKPQLLQQGQPQQSSLE--------PIPAVPQIKKEPVQTQGPFLDLHGLSLTSAEE 684
            .||..:|.|     ||.|.|.|..|        |:|. |.:...|...|.|
Worm   449 NLARLKLSQ-----QQNQNQNSDSESDTEMKICPLPN-PPLTLAPTHQQIP-------------- 493

  Fly   685 LIMEQALEMEECGLYDAPNANTEMGTSDNAISDSAAALHFQIKNELPDELLPDDDFLPCKPSDRL 749
                     ....:|........:|:.....|.:...|:|.:
Worm   494 ---------PPVNIYAQQPPPNPLGSILGNTSLTPQTLNFGL----------------------- 526

  Fly   750 PCPSLESSPFSS-PASMELTAVSCASS------VAISTNALPVRSGNYYLPAFTLNAHGKL--SS 805
              |||.|:.||| .|....|.|...:|      .|...:|:|.......|.||.     |:  ||
Worm   527 --PSLSSASFSSLNAHAPFTPVELPNSADFGPLTASKPHAVPFHPSEMCLSAFR-----KVPESS 584

  Fly   806 TGNGVQSVTTSLAQTPSVSMVNVPLLVRSNQMLPSVDTLLFTNQTGGSRFFAGKSAT------AA 864
            :.:|:.|::||:..|.         |:...|..|..:.||..|........:|.|||      |.
Worm   585 SISGLGSLSTSILSTQ---------LLLQLQHTPDFNYLLNQNLLSSLAGLSGLSATLGPQLQAT 640

  Fly   865 TP 866
            ||
Worm   641 TP 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	4/19 (21%)
		RPB9	333..425	CDD:224510	34/108 (31%)
		C2H2 Zn finger	333..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..369	CDD:290200	8/25 (32%)
		zf-C2H2	358..380	CDD:278523	9/21 (43%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..395	CDD:290200	10/22 (45%)
		zf-C2H2	386..408	CDD:278523	7/22 (32%)
		C2H2 Zn finger	388..436	CDD:275368	20/105 (19%)
		zf-H2C2_2	400..425	CDD:290200	9/40 (23%)
		C2H2 Zn finger	416..433	CDD:275368	10/73 (14%)
		zf-H2C2_2	429..453	CDD:290200	10/23 (43%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		zf-H2C2_2	457..481	CDD:290200	11/23 (48%)
		C2H2 Zn finger	472..493	CDD:275368	5/20 (25%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	6/19 (32%)
		zf-H2C2_2	119..143	CDD:290200	7/23 (30%)
		C2H2 Zn finger	134..154	CDD:275368	8/19 (42%)
		zf-H2C2_2	147..171	CDD:290200	11/23 (48%)
		C2H2 Zn finger	162..180	CDD:275368	5/17 (29%)
		COG5048	<187..404	CDD:227381	47/233 (20%)
		C2H2 Zn finger	191..211	CDD:275370	4/19 (21%)
		C2H2 Zn finger	218..239	CDD:275368	1/20 (5%)
		C2H2 Zn finger	248..268	CDD:275368	3/19 (16%)
		zf-H2C2_2	260..285	CDD:290200	10/24 (42%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	11/24 (46%)
		C2H2 Zn finger	304..324	CDD:275368	6/24 (25%)
		C2H2 Zn finger	386..403	CDD:275368	3/28 (11%)
		C2H2 Zn finger	424..441	CDD:275368	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000