DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wdn and ZNF582

DIOPT Version :9

Sequence 1:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster
Sequence 2:	NP_001307300.2	Gene:	ZNF582 / 147948	HGNCID:	26421	Length:	517	Species:	Homo sapiens

Alignment Length:	285	Identity:	92/285 - (32%)
Similarity:	129/285 - (45%)	Gaps:	44/285 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 HKCLDCNGLLLETPDEVAKHEAAAHRLRLTYRCSECQREFELLAGLKKHLKTHRTEGRKDTWKKC 333
            :||.:| |...:....:.:|| ..|..:..|.|.||.:.|...:...:|.:.|  .|.|.  .:|
Human   199 YKCKEC-GKAFKYGSRLIQHE-NIHSGKKPYECKECGKAFNSGSNFIQHQRVH--TGEKP--YEC 257

  Fly   334 PDCGKCLKLGSMWM-HRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKPYECPECQKRFQE 397
            .||.|.....|..: |::.|:..|.|||..||:.|.:..:|..|.|||:.||||.|.||.|.|..
Human   258 KDCEKAFSRSSQLIEHQRTHTGEKPYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSH 322

  Fly   398 RSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSN 462
            ||.|.:||..|...:.|.|::|||.:.....|..|..:|..::|:.|.||.|:|..:|:||||..
Human   323 RSQLIQHQTVHTGRKLYECKECGKAFNQGSTLIRHQRIHTGEKPYECKVCGKAFRVSSQLKQHQR 387

  Fly   463 IHTGMRPFKCNYCPRDFTNFPNWLKHTRRRHKVDHKTGE------------------------HL 503
            ||||.:|::|..|.|.|....:...|.|..      |||                        |.
Human   388 IHTGEKPYQCKVCGRAFKRVSHLTVHYRIH------TGEKPYECKECGKAFSHCSQLIHHQVIHT 446

  Fly   504 ENIP---SYCSK----KSTTNKAQK 521
            |..|   ..|.|    .|||.:.|:
Human   447 EKKPYEYKECEKTLSHDSTTVQPQR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		RPB9	333..425	CDD:224510	39/92 (42%)
		C2H2 Zn finger	333..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..369	CDD:290200	10/25 (40%)
		zf-C2H2	358..380	CDD:278523	9/21 (43%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		zf-H2C2_2	372..395	CDD:290200	13/22 (59%)
		zf-C2H2	386..408	CDD:278523	11/21 (52%)
		C2H2 Zn finger	388..436	CDD:275368	18/47 (38%)
		zf-H2C2_2	400..425	CDD:290200	9/24 (38%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	9/23 (39%)
		C2H2 Zn finger	444..464	CDD:275368	10/19 (53%)
		zf-H2C2_2	457..481	CDD:290200	13/23 (57%)
		C2H2 Zn finger	472..493	CDD:275368	6/20 (30%)
ZNF582	NP_001307300.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4021
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950