DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10000 and Galnt5

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_113984.1	Gene:	Galnt5 / 83627	RGDID:	620361	Length:	930	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	168/509 - (33%)
Similarity:	260/509 - (51%)	Gaps:	88/509 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 YNIHLSNALGLIRKLPVTRHHSCTTR--NSILPAPLEANVSVVISFHNEARSMLLRTIVSLLSRS 137
            :|::||:.:.:.|.:..||...|..:  ::.||     ..|:::.|.:|..|.|||::.|:|:||
  Rat   454 FNVYLSDLIPVDRAIEDTRPAGCAEQLVHNDLP-----TTSIIMCFVDEVWSALLRSVHSVLNRS 513

  Fly   138 PEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRGASLASG 202
            |...:.|::||||.|.:|. |..:|.::|     |::. .:..||.:||.|||.:|..||..|:|
  Rat   514 PPHLIKEILLVDDFSTKDY-LKANLDKYM-----SQFP-KVRILRLKERHGLIRARLAGAQNATG 571

  Fly   203 RYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRKGNELLKGGFDWSLHFHW 267
            ..:.|||||.|.|.|||||||||:.||......|:::.|:...:||...:...:|.|.|.::|.|
  Rat   572 DVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDNFQRGVFTWPMNFGW 636

  Fly   268 --------LKRQLTNQESLEMPYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLW 324
                    .|..:...:.:    :.|..|||:..:.:.:|.:||:::|.|.:||||::||:.|:|
  Rat   637 RTIPPDVIAKNGIKETDII----RCPVMAGGLFSIDKSYFYELGTYDPGLDVWGGENMELSFKVW 697

  Fly   325 LCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNMFYALRP 389
            :|||:|||:||||:|||||..:.:.||  .||     .:|...|...:||.||||||.:||...
  Rat   698 MCGGEIEIIPCSRVGHIFRNDNPYSFP--KDR-----MKTVERNLVRVAEVWLDEYKELFYGHG- 754

  Fly   390 AARRIPLDHTYD---------ELQRMRKERRCHPFEWYLRHVSPELRMHFDELSATGTLRN--ED 443
                   ||..|         :.:.:||:.:|..|:|||.:|.|:|:.  ..:.|:|...|  ..
  Rat   755 -------DHLIDQGLDVGNLTQQRELRKKLKCQSFKWYLDNVFPDLKA--PVVRASGVFINLALG 810

  Fly   444 RCVHARQKDSQPILASCYLSDITQWSMLRQSG----QLSTHRELCLA-VGFGMRIALEPC-GRNE 502
            :||..  |:...:|..|..|     |.|:|..    :|..|.|.|:| :.....:.|.|| .||.
  Rat   811 KCVSI--KNITVVLEDCDGS-----SELQQFNYTWVRLIKHGEWCVAPIPDKGSLTLYPCDNRNN 868

  Fly   503 TVRRSQRWVRLGTHLLHAESHLCLDNPLKDRLEMSTCRSHAVSQSFQFALEMEG 556
            .:    :|:.......|.|        |.|         |.|.:|:|..|.|||
  Rat   869 RL----KWLHRSASAFHPE--------LVD---------HIVFESYQQLLCMEG 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	121/325 (37%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	29/120 (24%)
Galnt5	NP_113984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377
		WcaA	484..>599	CDD:223539	54/126 (43%)
		Catalytic subdomain A	485..594		51/120 (43%)
		pp-GalNAc-T	489..790	CDD:133004	121/326 (37%)
		Catalytic subdomain B	654..716		30/65 (46%)
		RICIN	804..925	CDD:214672	33/126 (26%)
		RICIN	810..924	CDD:238092	32/120 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820