DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10000 and Galnt14

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_082140.2	Gene:	Galnt14 / 71685	MGIID:	1918935	Length:	550	Species:	Mus musculus

Alignment Length:	526	Identity:	188/526 - (35%)
Similarity:	269/526 - (51%)	Gaps:	86/526 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 WRVFISHTPETSED---FYQYNIHLSNALGLIRKLPVTRHHSCTTRNSILPAPLEANVSVVISFH 119
            |||        .:|   .|.:|...|..:...|.:|.|||..|:........|   ..|::|:||
Mouse    67 WRV--------GDDPYKLYAFNQRESERISSNRAVPDTRHKRCSLLVYCTDLP---PTSIIITFH 120

  Fly   120 NEARSMLLRTIVSLLSRSPEDYLHELILVDDGSQ--RDVTLLDDLKRWMGGVFGSRYRLGLTFLR 182
            |||||.|||||.|:|:|:|...:.|:|||||.|.  .|...|..|.:             :..||
Mouse   121 NEARSTLLRTIRSVLNRTPMHLIQEIILVDDFSNDPEDCKQLIKLPK-------------VKCLR 172

  Fly   183 NQERMGLIWSRNRGASLASGRYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLS 247
            |.||.||:.||.|||.:|.|..:.|||||||||..||:|||.|:..:....|.|::|.|:..|.:
Mouse   173 NNERQGLVRSRMRGADIAQGTTLTFLDSHCEVNRDWLQPLLHRVKEDYTRVVCPVIDIINLDTFN 237

  Fly   248 YRKGNELLKGGFDWSLHFHWLKRQLTNQESLEM----PYQSPAFAGGVLMMSREWFLKLGSFNPY 308
            |.:....|:|||||||||.|.:..| .|::|.:    |.::|..|||:.::.:.||..||.::..
Mouse   238 YIESASELRGGFDWSLHFQWEQLSL-EQKALRLDPTEPIRTPIIAGGLFVIDKAWFDYLGKYDVD 301

  Fly   309 LKIWGGESIELAIKLWLCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIA 373
            :.|||||:.|::.::|:|||.:||:||||:||:||::|.:.||..:       ..||:.|:|..|
Mouse   302 MDIWGGENFEISFRVWMCGGGLEIIPCSRVGHVFRKKHPYVFPDGN-------ANTYIKNTKRTA 359

  Fly   374 ESWLDEYKNMFYALRPAARRIPLDHTYDELQRMRKERRCHPFEWYLRHVSPELRMHFDELSATGT 438
            |.|:||||..:||.||.|...|..:..:.| .:||...|..|:|||.:|.||||:..|.....|.
Mouse   360 EVWMDEYKQYYYAARPFALERPFGNIENRL-NLRKNLHCQTFKWYLENVYPELRVPPDSSIQKGN 423

  Fly   439 LRNEDRCVHARQKDSQPIL------------------ASCYLSDITQWSMLRQSGQLSTHRELCL 485
            :|...:|:.::::..|.||                  |..|...|.|             .||||
Mouse   424 IRQRQKCLESQKQKKQEILRLSPCAKVKGDGAKSQVWAFTYTQQIIQ-------------EELCL 475

  Fly   486 AVGF---GMRIALEPCGRNETVRRSQRWVRLGTHLLHAESHLCLDNPL-----KDRLE--MSTCR 540
            :|..   |..:.|..|...:   ..|.|.:.|..:.|..||||||..:     :|..|  ::.|.
Mouse   476 SVVTLFPGAPVVLALCKNGD---ERQLWTKTGARIEHIASHLCLDTDMFGDSTEDGKEVVVNPCE 537

  Fly   541 SHAVSQ 546
            |..:||
Mouse   538 SSLMSQ 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	134/314 (43%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	34/140 (24%)
Galnt14	NP_082140.2	Catalytic subdomain A	110..215		57/120 (48%)
		Glyco_tranf_2_3	111..337	CDD:290369	106/242 (44%)
		pp-GalNAc-T	114..408	CDD:133004	134/315 (43%)
		Catalytic subdomain B	274..336		27/61 (44%)
		RICIN	422..547	CDD:238092	34/138 (25%)
		Ricin_B_lectin	422..545	CDD:279046	34/138 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3365
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	1	1.000	-	-		FOG0001204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.830