Protein Alignment CG10000 and GALNT9

DIOPT Version :10

• Sequence 1: NP_651630.3
• Gene: CG10000 / 43394
• FlyBaseID: FBgn0039596
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001116108.1
• Gene: GALNT9 / 50614
• HGNCID: 4131
• Length: 603
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 148/522 - (28%)
• Similarity: 238/522 - (45%)
• Gaps: 113/522 - (21%)

  Fly    73 YQYNIHLSNALGLIRKLPVTRHHSCTTRNSILPAPLEANVSVVISFHNEARSMLLRTIVSLLSRS 137
            |.||..||:.:.|.|.:|..|...|...:.....|   .||||..|.|||.|::||::.|:::.:
Human   117 YGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLP---QVSVVFIFVNEALSVILRSVHSVVNHT 178

  Fly   138 PEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRGASLASG 202
            |...|.|:|||||.|. :|.|..:|.:::    ..||...:..:||..|.|||.:|.:|...|:.
Human   179 PSQLLKEVILVDDNSD-NVELKFNLDQYV----NKRYPGLVKIVRNSRREGLIRARLQGWKAATA 238

  Fly   203 RYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRKGNELLKGGFDWSLHFHW 267
            ..|.|.|:|.|.|.||.||.|.|:..:....|.|.:|.|..:|...::...... |::|.|   |
Human   239 PVVGFFDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYANAAH-GYNWGL---W 299

  Fly   268 LKRQLTNQESLE-----MPYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLWLCG 327
            ....:..|:.|:     .|.::||..|...::.||:|..:|..:|.::::|||::||.:::|.||
Human   300 CMYIIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMRVWQCG 364

  Fly   328 GQIEIVPCSRIGHIFRRRHAF--DFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNMFYALRPA 390
            |.:|::||||:.||.|.|..:  |....:.|           |:...||.|:|::|:..|    .
Human   365 GSMEVLPCSRVAHIERTRKPYNNDIDYYAKR-----------NALRAAEVWMDDFKSHVY----M 414

  Fly   391 ARRIPLDH------TYDELQRMRKERRCHPFEWYLRHVSPELRMHFDELSATGTLRNE------- 442
            |..||:.:      ...|...:|:..:|..|:|||.:|.||:|::.:.|: .|.:||.
Human   415 AWNIPMSNPGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLT-YGEVRNSKASAYCL 478

  Fly   443 -------DRCV----HARQK-----------------------DSQ----------PILASCYLS 463
                   ||.:    |....                       ||:          |.|..|  .
Human   479 DQGAEDGDRAILYPCHGMSSQLVRYSADGLLQLGPLGSTAFLPDSKCLVDDGTGRMPTLKKC--E 541

  Fly   464 DITQ-----WSMLRQSGQL---STHRELCLAV------GFGMRIALEPCGRNETVRRSQRWVRLG 514
            |:.:     |. ..|||.:   :|.|  ||.|      .||:|:.::.|...:.:.|:  |::..
Human   542 DVARPTQRLWD-FTQSGPIVSRATGR--CLEVEMSKDANFGLRLVVQRCSGQKWMIRN--WIKHA 601

  Fly   515 TH 516
            .|
Human   602 RH 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	103/321 (32%)
		beta-trefoil_Ricin-like	432..550	CDD:483949	29/150 (19%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		47/118 (40%)
		pp-GalNAc-T	154..453	CDD:133004	103/322 (32%)
		Catalytic subdomain B	318..380		25/61 (41%)
		beta-trefoil_Ricin_GALNT9	456..600	CDD:467351	29/151 (19%)