Protein Alignment CG10000 and GALNT8

DIOPT Version :9

• Sequence 1: NP_651630.3
• Gene: CG10000 / 43394
• FlyBaseID: FBgn0039596
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_059113.1
• Gene: GALNT8 / 26290
• HGNCID: 4130
• Length: 637
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 167/532 - (31%)
• Similarity: 270/532 - (50%)
• Gaps: 75/532 - (14%)

  Fly    67 ETSEDFYQ---YNIHLSNALGLIRKLPVTRHHSC--TTRNSILPAPLEANVSVVISFHNEARSML 126
            :.::|.::   ||.:|||.|.|.|.:|.||.:.|  .|..|.||     ::||::.|.|||.|::
Human   138 KAAQDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLP-----SLSVILIFVNEALSII 197

  Fly   127 LRTIVSLLSRSPEDYLHELILVDDGS---QRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMG 188
            .|.|.|:::|:|...|.|:|||||.|   :..|.|.:.:|     ::..:|...|..:|:.||.|
Human   198 QRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIK-----LYNQKYPGLLKIIRHPERKG 257

  Fly   189 LIWSRNRGASLASGRYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRKGNE 253
            |..:||.|...|:...|..||:|.|||.||.||:|.|:..:..:.|||:.|.|...|....| .|
Human   258 LAQARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDK-YE 321

  Fly   254 LLKGGFDWSLHFHWLKRQLTNQESLEM-----PYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWG 313
            |...||:|.|   |.:.....|..:::     |.:||:.. |:|..:|.:..::||.:..:.|:|
Human   322 LAVDGFNWEL---WCRYDALPQAWIDLHDVTAPVKSPSIM-GILAANRHFLGEIGSLDGGMLIYG 382

  Fly   314 GESIELAIKLWLCGGQIEIVPCSRIGHIFR--RRHAFDFPPQSDRQLSPAQETYLHNSKIIAESW 376
            ||::||::::|.|||::||:|||||.|:.|  :.:|.|......|           |:..:||.|
Human   383 GENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYALDLTAALKR-----------NALRVAEIW 436

  Fly   377 LDEYKNMFYALRPAARRIPLDHT----YDELQRM--RKERRCHPFEWYLRHVSPELR-MHFDELS 434
            :||:|:|.|    .|..|||.::    .|...||  |::.:|..|:|||::|.|.|: :|  .:.
Human   437 MDEHKHMVY----LAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYPLLKPLH--TIV 495

  Fly   435 ATGTLRN---EDRCV-HARQKDSQPILASC--YLSDITQWSMLRQ--SGQL---STHRELCLA-V 487
            ..|.::|   |:.|: ......:.||:..|  :.|....:.:..:  .|||   ::..:.||. .
Human   496 GYGRMKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDP 560

  Fly   488 GFGMRIALEPCGRNETVRRSQRW-VRLGTHLLHAESHLCLDNPLKDR-----LEMSTCRSHAVSQ 546
            |...:..||||.:....|....| .:.|..:::.::..||:.. ||.     |.:.||.:..  .
Human   561 GKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMK-KDLLGSHVLVLQTCSTQV--W 622

  Fly   547 SFQFALEMEGQT 558
            ..|..:...|||
Human   623 EIQHTVRDWGQT 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	114/324 (35%)
		Ricin_B_lectin	435..548	CDD:279046	28/130 (22%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		1/9 (11%)
		SMC_N	<48..>161	CDD:330553	8/22 (36%)
		GT1 motif	182..298		47/120 (39%)
		pp-GalNAc-T	184..485	CDD:133004	114/325 (35%)
		Gal/GalNAc transferase motif	358..397		13/39 (33%)
		RICIN	498..624	CDD:238092	28/128 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810