DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10000 and Galnt12

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_766281.1	Gene:	Galnt12 / 230145	MGIID:	2444664	Length:	576	Species:	Mus musculus

Alignment Length:	485	Identity:	167/485 - (34%)
Similarity:	249/485 - (51%)	Gaps:	54/485 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ETSEDFYQYNIHLSNALGLIRKLPVTRHHSCTTRN---SILPAPLEANVSVVISFHNEARSMLLR 128
            |.|...:|.||:||:.:.|.|:||...:..|....   ..||     ..||||:|:|||.|.|||
Mouse    90 EESVKQHQINIYLSDRISLHRRLPERWNPLCREVKYDYDNLP-----KTSVVIAFYNEAWSTLLR 149

  Fly   129 TIVSLLSRSPEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSR 193
            |:.|:|..||:..|.|:|||||.|.|     :.||..:........::.|  :|...|.||:.:|
Mouse   150 TVYSVLETSPDILLEEVILVDDYSDR-----EHLKERLANELSQLPKVRL--IRASRREGLVRAR 207

  Fly   194 NRGASLASGRYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRKGN--ELLK 256
            ..|||.|.|..:.|||.|||.:||||||||:|:....:..|.|::|.||..|..| .||  |...
Mouse   208 LLGASAARGEVLTFLDCHCECHEGWLEPLLQRIHEKESAVVCPVIDVIDWNTFEY-LGNSGEPQI 271

  Fly   257 GGFDWSLHFHWLKRQLTNQESLEMP---YQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIE 318
            |||||.|.|.|.......::|:..|   .:||..|||:..:|:.:|..|||::..:::||||::|
Mouse   272 GGFDWRLVFTWHVVPQRERQSMRSPIDVIRSPTMAGGLFAVSKRYFDYLGSYDTGMEVWGGENLE 336

  Fly   319 LAIKLWLCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNM 383
            .:.::|.|||.:|..|||.:||:        ||.|:....|.|    |.||...||.|:||:|.:
Mouse   337 FSFRIWQCGGTLETHPCSHVGHV--------FPKQAPYSRSKA----LANSVRAAEVWMDEFKEL 389

  Fly   384 FYALRPAARRIPL-DHTYDELQRMRKERRCHPFEWYLRHVSPELRMHFDELSATGTLRN---EDR 444
            :|...|.||..|. |.|  |.:::|.:.:|..|:|:|..|.|||.:..|.....|.|:|   ...
Mouse   390 YYHRNPQARLEPFGDVT--ERKKLRAKLQCKDFKWFLDTVYPELHVPEDRPGFFGMLQNRGLRGY 452

  Fly   445 CVHARQKDS------QPILASCY---LSDITQWSMLRQSGQLSTHRELCLAVGFGM-RIALEPCG 499
            |:.....:.      |.:|..|:   .:...:::..::....:...|.|:.|..|. .:.::.|
Mouse   453 CLDYNPPNENHVEGHQVLLYLCHGMGQNQFFEYTTRKEIRYNTRQPEACITVEDGKDTLVMDLC- 516

  Fly   500 RNETVRRSQRWV--RLGTHLLHAESHLCLD 527
             .|||..:|.::  ..|| |:|..|..|::
Mouse   517 -RETVPENQEFILQEDGT-LVHKHSRKCVE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	126/314 (40%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	22/108 (20%)
Galnt12	NP_766281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58
		WcaA	129..424	CDD:223539	127/321 (40%)
		Catalytic subdomain A	130..239		55/120 (46%)
		pp-GalNAc-T	134..428	CDD:133004	126/315 (40%)
		Catalytic subdomain B	299..361		25/69 (36%)
		Ricin_B_lectin	440..569	CDD:279046	22/108 (20%)
		RICIN	442..571	CDD:238092	22/106 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820