DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10000 and gly-5

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001379253.1	Gene:	gly-5 / 176736	WormBaseID:	WBGene00001630	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	178/548 - (32%)
Similarity:	279/548 - (50%)	Gaps:	76/548 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NELLSFMNESEESDHLDWRVFISHTPETSEDFYQY---------NIHLSNALGLIRKLPVTRHHS 96
            |:.:....::.::..|...|.:..|..::|:..:|         |.:.|:.:.:.|.||......
Worm   100 NDPIYKKGDAAQAGELGKAVVVDKTKLSTEEKAKYDKGMLNNAFNQYASDMISVHRTLPTNIDAE 164

  Fly    97 CTTR--NSILPAPLEANVSVVISFHNEARSMLLRTIVSLLSRSPEDYLHELILVDDGSQRDVTLL 159
            |.|.  |..||     ..||:|.|||||.|:||||:.|:|.|:|:..|.|::||||.|..|.| .
Worm   165 CKTEKYNENLP-----RTSVIICFHNEAWSVLLRTVHSVLERTPDHLLEEVVLVDDFSDMDHT-K 223

  Fly   160 DDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRGASLASGRYVLFLDSHCEVNEGWLEPLLE 224
            ..|:.:| ..||.:.::    ||.::|.|||.:|.|||::|:|..:.:||||||..|||:||||:
Worm   224 RPLEEYM-SQFGGKVKI----LRMEKREGLIRARLRGAAVATGEVLTYLDSHCECMEGWMEPLLD 283

  Fly   225 RLALNTNLAVSPLLDPIDPTTLSYRKGNELLK--GGFDWSLHFHW---LKRQLTNQESLEMPYQS 284
            |:..:....|.|::|.||..|..|........  |||||.|.|:|   .:|...|:.....|.:|
Worm   284 RIKRDPTTVVCPVIDVIDDNTFEYHHSKAYFTSVGGFDWGLQFNWHSIPERDRKNRTRPIDPVRS 348

  Fly   285 PAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLWLCGGQIEIVPCSRIGHIFRRRHAFD 349
            |..|||:..:.:::|.|||:::|...|||||::||:.|:|:|||.:||||||.:||:||:|..:.
Worm   349 PTMAGGLFSIDKKYFEKLGTYDPGFDIWGGENLELSFKIWMCGGTLEIVPCSHVGHVFRKRSPYK 413

  Fly   350 FPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNMFYALRPAARRIPLDHTYDEL---------QR 405
            :        .........||..:||.|||:||..:|           :...::|         ::
Worm   414 W--------RTGVNVLKRNSIRLAEVWLDDYKTYYY-----------ERINNQLGDFGDISSRKK 459

  Fly   406 MRKERRCHPFEWYLRHVSPELRMHFDELSATGTLRNED-------RCVHARQKDSQPI-LASCYL 462
            :|::..|..|:|||.::.|||.:. .|..|.|.:||..       .|:..|.:.::|: ...|:.
Worm   460 LREDLGCKSFKWYLDNIYPELFVP-GESVAKGEVRNSAVQPARCLDCMVGRHEKNRPVGTYQCHG 523

  Fly   463 SDITQWSMLRQSGQLSTHRELCLAVGFGMRIALEPCGRNETVRRSQRWVRLG---THLLHAESHL 524
            ....|:.||.:.|:: ...|.|:... |..:.:.||   ..::.:|.| |..   ..|.||.|..
Worm   524 QGGNQYWMLSKDGEI-RRDESCVDYA-GSDVMVFPC---HGMKGNQEW-RYNHDTGRLQHAVSQK 582

  Fly   525 CLDNPLKD--RLEMSTCRSHAVSQSFQF 550
            || ...||  :|||..|:.....|.::|
Worm   583 CL-GMTKDGAKLEMVACQYDDPYQHWKF 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	124/322 (39%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	33/125 (26%)
gly-5	NP_001379253.1	pp-GalNAc-T	178..477	CDD:133004	124/323 (38%)
gly-5	NP_001379253.1	Ricin_B_lectin	488..607	CDD:395527	33/125 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920