DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10000 and Galnt10

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_598950.2	Gene:	Galnt10 / 171212	MGIID:	1890480	Length:	603	Species:	Mus musculus

Alignment Length:	511	Identity:	165/511 - (32%)
Similarity:	265/511 - (51%)	Gaps:	69/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 YNIHLSNALGLIRKLPVTRHHSCTTRNSILPAPLEANVSVVISFHNEARSMLLRTIVSLLSRSPE 139
            :||::|:.:.|.|.||..||.:|.::..:...|   |.|::|.||||..|.||||:.|:|:|||.
Mouse   113 FNIYVSDKISLNRSLPDIRHPNCNSKLYLETLP---NTSIIIPFHNEGWSSLLRTVHSVLNRSPP 174

  Fly   140 DYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRGASLASGRY 204
            :.:.|::||||.|.|: .|...|:.:| .:|.|     :..||.::|.|||.:|..|||.|:|..
Mouse   175 ELVAEIVLVDDFSDRE-HLKKPLEDYM-ALFPS-----VRILRTKKREGLIRTRMLGASAATGDV 232

  Fly   205 VLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYR-KGNELLKGGFDWSLHFHWL 268
            |.|||||||.|..||.|||:|:|.|....|.|::|.||.....|. :..:.::|.|||.:::
Mouse   233 VTFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYY--- 294

  Fly   269 KR-----QLTNQESLEMPYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLWLCGG 328
            ||     :|...:..: |::||..|||:..:.|:||.:||.::|.|:|||||..|::.|:|:|||
Mouse   295 KRIPIPPELQKADPSD-PFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGG 358

  Fly   329 QIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNMFYALRPAARR 393
            ::|.:||||:|||:|:     :.|..    .||..:...|.|.:||.|:|||....|..||..|.
Mouse   359 RMEDIPCSRVGHIYRK-----YVPYK----VPAGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRH 414

  Fly   394 IPLDHTYDELQRMRKERRCHPFEWYLRHVSPELRMHFDEL----SATGTLRNE------------ 442
            :.......: :::|....|..|:|::..::.:|...:..:    :|.|.:||.
Mouse   415 LSAGDVVAQ-KKLRVSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCTDTKLGT 478

  Fly   443 -------DRCVHARQK---DSQPILASCYLSDITQWSMLRQSGQLSTHRELCL-AVGFGMRIALE 496
                   :.|:..|.:   :|..:....:..||       :.|.....::.|. ||.....:.|.
Mouse   479 LGSPLRLETCIRGRGEAAWNSMQVFTFTWREDI-------RPGDPQHTKKFCFDAVSHTSPVTLY 536

  Fly   497 PCGRNETVRRSQRW-VRLGTHLLHAESHLCLDNPLKD-RLEMSTCRSHAVSQSFQF 550
            .|   .:::.:|.| .|....|.|..|..|:|....| |:.|:||...:::|.:.|
Mouse   537 DC---HSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRVFMNTCNPSSLTQQWLF 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	122/314 (39%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	29/137 (21%)
Galnt10	NP_598950.2	WcaA	144..443	CDD:223539	124/322 (39%)
		Catalytic subdomain A	144..253		56/118 (47%)
		pp-GalNAc-T	148..443	CDD:133004	122/315 (39%)
		Catalytic subdomain B	311..373		32/61 (52%)
		Flexible loop. /evidence=ECO:0000250	373..384		4/19 (21%)
		Ricin_B_lectin	459..587	CDD:279046	29/137 (21%)
		RICIN	461..589	CDD:238092	28/137 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810