DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10000 and Galnt3

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_056551.2	Gene:	Galnt3 / 14425	MGIID:	894695	Length:	633	Species:	Mus musculus

Alignment Length:	616	Identity:	186/616 - (30%)
Similarity:	292/616 - (47%)	Gaps:	128/616 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HCSFYIIAFLICQLFFLVIFI------------------RNDDASSANELLSFMNESEES----- 53
            |..|:.:..:|  .||||:.|                  ||  ..:.|::|.||.|:..:
Mouse    17 HRKFWKLGAVI--FFFLVVLILMQREVSVQYSKEESKMERN--LKNKNKMLDFMLEAVNNIKDAM 77

  Fly    54 ----------DHLDWR----------------VF------------------ISH-TP------E 67
                      :::|.|                ||                  |:| :|      |
Mouse    78 PKMQIGAPIKENIDVRERPCLQGYYTAAELKPVFDRPPQDSNAPGASGKPFKITHLSPEEQKEKE 142

  Fly    68 TSEDFYQYNIHLSNALGLIRKL-PVTRHHSCTTRNSILPAPLEANVSVVISFHNEARSMLLRTIV 131
            ..|..:.:|...|:.:.|.|.| |.||...|..:......|| ...||:|.|||||.|.||||:.
Mouse   143 RGETKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPL-PTTSVIIVFHNEAWSTLLRTVH 206

  Fly   132 SLLSRSPEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRG 196
            |:|..||...|.|:|||||.|..|. |.:.|:.::     .::.: :..:|.|||.|||.:|..|
Mouse   207 SVLYSSPAILLKEIILVDDASVDDY-LHEKLEEYI-----KQFSI-VKIVRQQERKGLITARLLG 264

  Fly   197 ASLASGRYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRK----GNELLKG 257
            |::|:...:.|||:|||...|||||||.|:|.|....|||.:..||..|..:.|    |:...:|
Mouse   265 AAVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRG 329

  Fly   258 GFDWSLHFHW-----LKRQLTNQESLEMPYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESI 317
            .|||||.|.|     .::|....|:  .|.::|.||||:..:|:::|..:||::..::|||||:|
Mouse   330 NFDWSLSFGWESLPDHEKQRRKDET--YPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWGGENI 392

  Fly   318 ELAIKLWLCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKN 382
            |::.::|.||||:||:|||.:||:||.:....||        ...:....|...:||.|:||||.
Mouse   393 EMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFP--------KGTQVIARNQVRLAEVWMDEYKE 449

  Fly   383 MFYALRPAARRIPLDHTYDELQR---MRKERRCHPFEWYLRHVSPELRMHFDELS--ATGTLRN- 441
            :||.....|.:|....::.:|.:   ::|..:|..|.|||..:.||  .:..:|:  .:|.:::
Mouse   450 IFYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPE--AYVPDLNPVISGYIKSV 512

  Fly   442 -EDRC--VHARQKDSQP-ILASCY---LSDITQWSMLRQSGQLSTHRELCLAVGFGMRIALEPCG 499
             :..|  |....:..:| ||.:|:   .:...::|..|:. :.:..:||||....|: :.|:.|
Mouse   513 GQPLCLDVGENNQGGKPLILYTCHGLGGNQYFEYSAQREI-RHNIQKELCLHATQGV-VQLKAC- 574

  Fly   500 RNETVRRSQRWVRLGTHLLHAESHLCLDNPL 530
                |.:..|.:..|..:........|.|||
Mouse   575 ----VYKGHRTIAPGEQIWEIRKDQLLYNPL 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	125/320 (39%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	23/104 (22%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..145		4/32 (13%)
		WcaA	184..>302	CDD:223539	56/125 (45%)
		Catalytic subdomain A	184..293		53/116 (46%)
		pp-GalNAc-T	188..493	CDD:133004	125/321 (39%)
		Catalytic subdomain B	356..418		29/61 (48%)
		Ricin_B_lectin	506..627	CDD:279046	23/103 (22%)
		RICIN	507..629	CDD:238092	23/102 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820