DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10000 and GALNT5

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_016858726.1	Gene:	GALNT5 / 11227	HGNCID:	4127	Length:	956	Species:	Homo sapiens

Alignment Length:	513	Identity:	168/513 - (32%)
Similarity:	269/513 - (52%)	Gaps:	80/513 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 YNIHLSNALGLIRKLPVTRHHSCTTR--NSILPAPLEANVSVVISFHNEARSMLLRTIVSLLSRS 137
            :|::||:.:.:.|.:..||...|..:  ::.||     ..||::.|.:|..|.|||::.|:::||
Human   464 FNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLP-----TTSVIMCFVDEVWSTLLRSVHSVINRS 523

  Fly   138 PEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERMGLIWSRNRGASLASG 202
            |...:.|::||||.|.:|. |.|:|.::|     |::. .:..||.:||.|||.:|..||..|:|
Human   524 PPHLIKEILLVDDFSTKDY-LKDNLDKYM-----SQFP-KVRILRLKERHGLIRARLAGAQNATG 581

  Fly   203 RYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRKGNELLKGGFDWSLHFHW 267
            ..:.|||||.|.|.|||||||||:.|:......|:::.|:...:||...:...:|.|.|.::|.|
Human   582 DVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDNFQRGIFVWPMNFGW 646

  Fly   268 --------LKRQLTNQESLEMPYQSPAFAGGVLMMSREWFLKLGSFNPYLKIWGGESIELAIKLW 324
                    .|.::...:::    :.|..|||:..:.:.:|.:||:::|.|.:||||::||:.|:|
Human   647 RTIPPDVIAKNRIKETDTI----RCPVMAGGLFSIDKSYFFELGTYDPGLDVWGGENMELSFKVW 707

  Fly   325 LCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIAESWLDEYKNMFYALRP 389
            :|||:|||:||||:|||||..:.:.||  .||     .:|...|...:||.||||||.:||...
Human   708 MCGGEIEIIPCSRVGHIFRNDNPYSFP--KDR-----MKTVERNLVRVAEVWLDEYKELFYGHG- 764

  Fly   390 AARRIPLDHTYD---------ELQRMRKERRCHPFEWYLRHVSPELRMHFDELSATGTLRNE--D 443
                   ||..|         :.:.:||:.:|..|:|||.:|.|:||...  :.|:|.|.|.  .
Human   765 -------DHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAPI--VRASGVLINVALG 820

  Fly   444 RCVHARQKDSQPILASCYLSDITQ-----WSMLRQSGQLSTHRELCLA-VGFGMRIALEPC-GRN 501
            :|:..  :::..||..|..|...|     |..|.:.|      |.|:| :.....:.|.|| .||
Human   821 KCISI--ENTTVILEDCDGSKELQQFNYTWLRLIKCG------EWCIAPIPDKGAVRLHPCDNRN 877

  Fly   502 ETVRRSQRWVRLGTHLLHAE---SHLCLDNPLKDRLEMSTCRSHAVSQSFQFALEMEG 556
                :..:|:...|.:.|.|   :..|...|....|::    :|.|.::.|..|.:||
Human   878 ----KGLKWLHKSTSVFHPELLSNSACGSFPALLSLQV----NHIVFENNQQLLCLEG 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	121/325 (37%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	30/124 (24%)
GALNT5	XP_016858726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820