DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10000 and GALNT6

DIOPT Version :9

Sequence 1:	NP_651630.3	Gene:	CG10000 / 43394	FlyBaseID:	FBgn0039596	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_009141.2	Gene:	GALNT6 / 11226	HGNCID:	4128	Length:	622	Species:	Homo sapiens

Alignment Length:	523	Identity:	175/523 - (33%)
Similarity:	267/523 - (51%)	Gaps:	64/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 TP-ETSEDFYQYNIHLSNA-----LGLIRKL-PVTRHHSCTTRNSILPAPLEANVSVVISFHNEA 122
            || ||.|....|..|..||     :.|.|.| |.||...|..:......|| |..||:|.|||||
Human   126 TPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPL-ATTSVIIVFHNEA 189

  Fly   123 RSMLLRTIVSLLSRSPEDYLHELILVDDGSQRDVTLLDDLKRWMGGVFGSRYRLGLTFLRNQERM 187
            .|.||||:.|:|..:|...|.|:|||||.|..: .|.:.|::::      :....:..:|.:||.
Human   190 WSTLLRTVYSVLHTTPAILLKEIILVDDASTEE-HLKEKLEQYV------KQLQVVRVVRQEERK 247

  Fly   188 GLIWSRNRGASLASGRYVLFLDSHCEVNEGWLEPLLERLALNTNLAVSPLLDPIDPTTLSYRK-- 250
            |||.:|..|||:|....:.|||:|||...|||||||.|:|.:..:.|||.:..||..|..:.|
Human   248 GLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPV 312

  Fly   251 --GNELLKGGFDWSLHFHW-----LKRQLTNQESLEMPYQSPAFAGGVLMMSREWFLKLGSFNPY 308
              |....:|.|||||.|.|     .::|....|:  .|.:||.||||:..:|:.:|..:|:::..
Human   313 QRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDET--YPIKSPTFAGGLFSISKSYFEHIGTYDNQ 375

  Fly   309 LKIWGGESIELAIKLWLCGGQIEIVPCSRIGHIFRRRHAFDFPPQSDRQLSPAQETYLHNSKIIA 373
            ::|||||::|::.::|.||||:||:|||.:||:||.:....||        ........|...:|
Human   376 MEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFP--------KGTSVIARNQVRLA 432

  Fly   374 ESWLDEYKNMFYALRPAARRIPLDHTYDELQ---RMRKERRCHPFEWYLRHVSPELRMHFDELSA 435
            |.|:|.||.:||.....|.::..:.::.::.   ::|::..||.|.|||.:|.||  |...:|:.
Human   433 EVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPE--MFVPDLTP 495

  Fly   436 T--GTLRN--EDRC--VHARQKDSQP-ILASC-------YLSDITQWSMLRQSGQLSTHRELCLA 486
            |  |.::|  .::|  |....:..:| |:.||       |....||..:     :.:..::|||.
Human   496 TFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDL-----RHNIAKQLCLH 555

  Fly   487 VGFGMRIALEPC---GRNETVRRSQRWVRLGTHLL-HAESHLCLDNPLKDRLEMSTCRSHAVSQS 547
            |..| .:.|..|   |:|..|.:.:.|......|: ::.|..||.:..| :..|:.|......|.
Human   556 VSKG-ALGLGSCHFTGKNSQVPKDEEWELAQDQLIRNSGSGTCLTSQDK-KPAMAPCNPSDPHQL 618

  Fly   548 FQF 550
            :.|
Human   619 WLF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10000	NP_651630.3	pp-GalNAc-T	113..422	CDD:133004	119/320 (37%)
CG10000	NP_651630.3	Ricin_B_lectin	435..548	CDD:279046	31/130 (24%)
GALNT6	NP_009141.2	Catalytic subdomain A	176..285		52/116 (45%)
		pp-GalNAc-T	180..485	CDD:133004	119/321 (37%)
		Catalytic subdomain B	348..410		28/61 (46%)
		Ricin_B_lectin	497..619	CDD:306998	30/128 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920