Protein Alignment AstA-R2 and CCKBR

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 100/512 - (19%)
• Similarity: 177/512 - (34%)
• Gaps: 192/512 - (37%)

  Fly     3 NTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNN 67
            |::.:.|:|....|    |....|.|..|||..||       :.||.:....||:|:|:|:..:.
Human    30 NSSSVGNLSCEPPR----IRGAGTRELELAIRITL-------YAVIFLMSVGGNMLIIVVLGLSR 83

  Fly    68 NMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLM 132
            .:|:.||..:::||.:||:..:.|:|||....::..:.:|...|::|.||:.|:...|..:||.:
Human    84 RLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAI 148

  Fly   133 SIDRFLAVVHPIRSRMMRTENITLIAIVTLWIV--VLVVSVPVAFTHDVVVDYDAKKNITYGMCT 195
            :::|:.|:..|:::|:.:|.:.....||..|::  :|:|..||
Human   149 ALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPV---------------------- 191

  Fly   196 FTTNDFLGPR---------------TYQVTFFISSYLLPLMIIS---GLYMRMI----------- 231
            :|....:|||               |:.|...:..:.:|.::::   ||..|.:
Human   192 YTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSD 256

  Fly   232 --------------------------MRLWR---------------------------------- 236
                                      ..|||
Human   257 SDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDW 321

  Fly   237 -------------------------------------------------------------QGTG 240
                                                                         .|:|
Human   322 AGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSG 386

  Fly   241 VRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSS 305
            .|.::.....:|||.|:::|:|:.|...||||......::.|....:.............|:|:|
Human   387 SRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYAS 451

  Fly   306 SCINPLLYAFLSENFRKAFYK-AVNCSSRYQNY------TSDLPPPRKTSCARTSTT 355
            :|:|||:|.|:...||:|..: ...|..|....      ..|.|.|...|.:|.|.|
Human   452 ACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYT 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	78/436 (18%)
		TM helix 1	40..66	CDD:320224	7/25 (28%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	10/29 (34%)
		TM helix 4	153..173	CDD:320224	5/21 (24%)
		TM helix 5	204..233	CDD:320224	8/83 (10%)
		TM helix 6	249..279	CDD:320224	11/29 (38%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	82/443 (19%)
		TM helix 1	57..81	CDD:320645	9/30 (30%)
		TM helix 2	90..112	CDD:320645	8/21 (38%)
		TM helix 3	128..150	CDD:320645	7/21 (33%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	3/22 (14%)
		TM helix 6	401..423	CDD:320645	8/21 (38%)
		TM helix 7	438..463	CDD:320645	9/24 (38%)