DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and KISS1R

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_115940.2	Gene:	KISS1R / 84634	HGNCID:	4510	Length:	398	Species:	Homo sapiens

Alignment Length:	325	Identity:	104/325 - (32%)
Similarity:	163/325 - (50%)	Gaps:	33/325 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AINGTLP-------WIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVI 89
            |.:|.:|       |:|..||..:.:.|..||.|||.|:..:..||:.||..|.||||.|:.|::
Human    29 ASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLL 93

  Fly    90 LCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENI 154
            .|:||||..|.:..|..|.|.|:.|.|:..|:..|:..||..||:||:...|.|:|:...||..:
Human    94 CCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRL 158

  Fly   155 TLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLG---PRTYQVTFFISSY 216
            .|...:::|:....||.||...|          .::.|...:.:..|..   .|.:.:...::.|
Human   159 ALAVSLSIWVGSAAVSAPVLALH----------RLSPGPRAYCSEAFPSRALERAFALYNLLALY 213

  Fly   217 LLPLMIISGLYMRMIMRLWRQGT----------GVRMSKESQRGRKRVTRLVVVVVIAFASLWLP 271
            ||||:.....|..|:..|.|...          |..:::.:...|.:|:|||..||:.||:.|.|
Human   214 LLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGP 278

  Fly   272 VQLILLLKSLDVI---ETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSR 333
            :||.|:|::|...   ...:.....::..|..::||:|.:||||||||..:||:||.:...|:.|
Human   279 IQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPR 343

Fly 334 333
Human 344 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	44/116 (38%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	85/273 (31%)
KISS1R	NP_115940.2	7tm_4	53..>157	CDD:304433	43/103 (42%)
		7tm_1	59..323	CDD:278431	85/273 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..363		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9822
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020