Protein Alignment AstA-R2 and MCHR2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_115892.2
• Gene: MCHR2 / 84539
• HGNCID: 20867
• Length: 340
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 87/313 - (27%)
• Similarity: 144/313 - (46%)
• Gaps: 41/313 - (13%)

  Fly    40 IVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYW 104
            |:....|:|..||..||:|::..:: .:..::..::.|.|||.|||:.:: .:||     :::.|
Human    36 ILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIV-GMPF-----LIHQW 93

  Fly   105 PYGRFW------CRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLW 163
            ..|..|      |..:..|.....||....:.:||:||:.|:|.|.|....||...|:...:.||
Human    94 ARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLW 158

  Fly   164 IVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRT---YQVTFFISSYLLPLMIISG 225
            ....::::||.....|:...|..::     |.|   |...|..   |.:...|:::..||.:|..
Human   159 AASFILALPVWVYSKVIKFKDGVES-----CAF---DLTSPDDVLWYTLYLTITTFFFPLPLILV 215

  Fly   226 LYMRMIMRLW---RQGTGVRMSKES---QRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVI 284
            .|:.::...|   :|....|....|   ||..| :|::|:|:|:.|.....|..:|.|:..  .:
Human   216 CYILILCYTWEMYQQNKDARCCNPSVPKQRVMK-LTKMVLVLVVVFILSAAPYHVIQLVNL--QM 277

  Fly   285 ETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENF--------RKAFYKAVN 329
            |..||...|....:..|:|:||.|||.||..||.||        |:|..|.:|
Human   278 EQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEIN 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	84/306 (27%)
		TM helix 1	40..66	CDD:320224	8/25 (32%)
		TM helix 2	73..99	CDD:320224	9/25 (36%)
		TM helix 3	111..141	CDD:320224	9/29 (31%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	7/31 (23%)
		TM helix 6	249..279	CDD:320224	10/29 (34%)
		TM helix 7	292..317	CDD:320224	10/24 (42%)
MCHR2	NP_115892.2	7tmA_MCHR2	35..317	CDD:320461	83/298 (28%)
		TM helix 1	36..62	CDD:320461	8/26 (31%)
		TM helix 2	68..94	CDD:320461	9/31 (29%)
		TM helix 3	106..136	CDD:320461	9/29 (31%)
		TM helix 4	148..168	CDD:320461	3/19 (16%)
		TM helix 5	194..223	CDD:320461	6/28 (21%)
		TM helix 6	244..274	CDD:320461	11/30 (37%)
		TM helix 7	285..310	CDD:320461	10/24 (42%)