DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and Kiss1r

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_076482.2	Gene:	Kiss1r / 78976	RGDID:	70930	Length:	396	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	107/345 - (31%)
Similarity:	171/345 - (49%)	Gaps:	36/345 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GTLP-----WIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPF 94
            |:.|     |:|..||..:.:.|..||.|||.|:..:.:|::.||..|.||||.|:.|::.|:||
  Rat    34 GSAPRPLDAWLVPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPF 98

  Fly    95 TATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAI 159
            ||..|.:..|..|.|.|:.|.|:..|:..|:..||..||:||:...|.|:|:...||..:.|...
  Rat    99 TALLYPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVS 163

  Fly   160 VTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLG---PRTYQVTFFISSYLLPLM 221
            :::|:....||.||...|          .::.|..|:.:..|..   .|.:.:...::.|||||:
  Rat   164 LSIWVGSAAVSAPVLALH----------RLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLL 218

  Fly   222 IISGLYMRMIMRLWRQGT----------GVRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLIL 276
            .....|..|:..|.|...          |..:::.:...|.:|:|||..||:.||:.|.|:||.|
  Rat   219 ATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFL 283

  Fly   277 LLKSL---DVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQ--- 335
            :|::|   ......:.....:::.|..::||:|.:||||||||..:||:||.:...|..:.|
  Rat   284 VLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCGPQRQRRP 348

  Fly   336 --NYTSDLPPPRKTSCARTS 353
              :..||...|.....:|.:
  Rat   349 HASAHSDRAAPHSVPHSRAA 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	43/116 (37%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	85/273 (31%)
Kiss1r	NP_076482.2	7tmA_KiSS1R	43..334	CDD:320223	97/300 (32%)
		TM helix 1	45..69	CDD:320223	10/23 (43%)
		TM helix 2	78..100	CDD:320223	11/21 (52%)
		TM helix 3	116..138	CDD:320223	7/21 (33%)
		TM helix 4	161..177	CDD:320223	3/15 (20%)
		TM helix 5	202..225	CDD:320223	6/22 (27%)
		TM helix 6	262..284	CDD:320223	11/21 (52%)
		TM helix 7	302..327	CDD:320223	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..396		4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020