Protein Alignment AstA-R2 and TACR2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 112/368 - (30%)
• Similarity: 165/368 - (44%)
• Gaps: 51/368 - (13%)

  Fly     8 ANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFF-FGVIAITGFFGNLLVILVVVFNNNMRS 71
            ||||.....|...||:|......||:     |...:. ..::|:|   ||.:||.:::.:..||:
Human    10 ANISSGPESNTTGITAFSMPSWQLAL-----WATAYLALVLVAVT---GNAIVIWIILAHRRMRT 66

  Fly    72 TTNLMIVNLAAADLMFVILCI-PFTATDYMVY----YWPYGRFWCRSVQYLIVVTA-FASIYTLV 130
            .||..|||||.||     ||: .|.|....||    .|.:||.:| ..|.|..:|| |.|||::.
Human    67 VTNYFIVNLALAD-----LCMAAFNAAFNFVYASHNIWYFGRAFC-YFQNLFPITAMFVSIYSMT 125

  Fly   131 LMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCT 195
            .::.||::|:|||.:.|:....  |...|..:|:|.|.::.|..|...|.:|..|.|      |.
Human   126 AIAADRYMAIVHPFQPRLSAPS--TKAVIAGIWLVALALASPQCFYSTVTMDQGATK------CV 182

  Fly   196 FTTNDFLGPRT---YQVTFFISSYLLPLMIISGLYMRMIMRLWR------QGTGVRMSKESQRGR 251
            ....:..|.:|   |.:......|.|||.::...|..:.:.|||      |..|..:  ...:..
Human   183 VAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANL--RHLQAM 245

  Fly   252 KRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQT--LAYSSSCINPLLYA 314
            |:..:.:|:||:.||..|||..|..:|.|..  |.....|.:.||....  ||.||:..||::|.
Human   246 KKFVKTMVLVVLTFAICWLPYHLYFILGSFQ--EDIYCHKFIQQVYLALFWLAMSSTMYNPIIYC 308

  Fly   315 FLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSCARTSTTGL 357
            .|:..||..|..|..|...       :.|.::.....|.||.|
Human   309 CLNHRFRSGFRLAFRCCPW-------VTPTKEDKLELTPTTSL 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	94/302 (31%)
		TM helix 1	40..66	CDD:320224	6/26 (23%)
		TM helix 2	73..99	CDD:320224	13/26 (50%)
		TM helix 3	111..141	CDD:320224	12/30 (40%)
		TM helix 4	153..173	CDD:320224	5/19 (26%)
		TM helix 5	204..233	CDD:320224	7/31 (23%)
		TM helix 6	249..279	CDD:320224	10/29 (34%)
		TM helix 7	292..317	CDD:320224	9/26 (35%)
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	95/309 (31%)
		TM helix 1	35..61	CDD:320670	7/33 (21%)
		TM helix 2	68..94	CDD:320670	14/30 (47%)
		TM helix 3	106..136	CDD:320670	12/30 (40%)
		TM helix 4	147..168	CDD:320670	6/22 (27%)
		TM helix 5	194..223	CDD:320670	6/28 (21%)
		TM helix 6	243..273	CDD:320670	10/29 (34%)
		TM helix 7	286..311	CDD:320670	9/24 (38%)