Protein Alignment AstA-R2 and NPFFR1

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_071429.1
• Gene: NPFFR1 / 64106
• HGNCID: 17425
• Length: 430
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 107/377 - (28%)
• Similarity: 175/377 - (46%)
• Gaps: 37/377 - (9%)

  Fly    10 ISLNATRNEENITSFFTDEEWLAINGTLPWIVGFF--FGVIAITGFFGNLLVILVVVFNNNMRST 72
            :|.|.|..|....:..|...:  ...|.|....|.  :.:|.:....||.||..:|:.|.:|.:.
Human    15 LSQNGTNTEATPATNLTFSSY--YQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTV 77

  Fly    73 TNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRF 137
            ||:.|:|||.:||:..|.|:|.|..|.::..||:....|:....:..::..||::|||.::::||
Human    78 TNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERF 142

  Fly   138 LAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFT-------HDVVVDYDAKKNITYGM-- 193
            ..:|||.|.::  |....|:.|..:|.:.|::..|.|.|       |..:||   .:|.:|.:
Human   143 RCIVHPFREKL--TLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVD---ARNRSYPLYS 202

  Fly   194 CTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKE------SQRGRK 252
            |.....:....|.|....|...||.||.:|..:|.|:..:|. |..|.....|      :.|.|.
Human   203 CWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLC-QAPGPAPGGEEAADPRASRRRA 266

  Fly   253 RVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQV--TAQTLAYSSSCINPLLYAF 315
            ||..::|:|.:.|...|||:..:|||.....:....|..:.:..  .|..||:.:|..||::|.:
Human   267 RVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGY 331

  Fly   316 LSENFRKAF---YKAVNC---SSRYQNYTSDLP----PPRKTSCARTSTTGL 357
            .:||||:.|   ::|..|   |..::...|:.|    ..|.....|.|.:||
Human   332 FNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGL 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	89/303 (29%)
		TM helix 1	40..66	CDD:320224	7/27 (26%)
		TM helix 2	73..99	CDD:320224	12/25 (48%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	10/28 (36%)
		TM helix 6	249..279	CDD:320224	12/29 (41%)
		TM helix 7	292..317	CDD:320224	7/26 (27%)
NPFFR1	NP_071429.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		2/4 (50%)
		7tm_GPCRs	44..340	CDD:475119	89/301 (30%)
		TM helix 1	46..70	CDD:410628	7/23 (30%)
		TM helix 2	79..101	CDD:410628	10/21 (48%)
		TM helix 3	117..139	CDD:410628	5/21 (24%)
		TM helix 4	160..176	CDD:410628	3/15 (20%)
		TM helix 5	214..237	CDD:410628	8/22 (36%)
		TM helix 6	269..291	CDD:410628	6/21 (29%)
		TM helix 7	308..333	CDD:410628	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..413		3/5 (60%)