Protein Alignment AstA-R2 and CYSLTR2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_065110.1
• Gene: CYSLTR2 / 57105
• HGNCID: 18274
• Length: 346
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 97/369 - (26%)
• Similarity: 167/369 - (45%)
• Gaps: 78/369 - (21%)

  Fly     3 NTTMLANISLNATRNEENI-TSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFN 66
            |.|...|.|.|.|  .||. ..||          .:.:::.||:||:      ||.|.|.|.:..
Human    20 NGTFSNNNSRNCT--IENFKREFF----------PIVYLIIFFWGVL------GNGLSIYVFLQP 66

  Fly    67 NNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYY-----WPYGRFWCRSVQYLIVVTAFASI 126
            ....::.|:.::|||.:||:| |..:||.|.    ||     |.:|...||.:.|.:.|..::||
Human    67 YKKSTSVNVFMLNLAISDLLF-ISTLPFRAD----YYLRGSNWIFGDLACRIMSYSLYVNMYSSI 126

  Fly   127 YTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKN--I 189
            |.|.::|:.||||:|||.|...:.:.....|....:||:::..|:       :::|..:::|  :
Human   127 YFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSI-------MLLDSGSEQNGSV 184

  Fly   190 T-------YGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYM---RMIMRLWRQGTGVRMS 244
            |       |.:....|.:::.        .:...|||...:|..|:   |:::::....:|:|:|
Human   185 TSCLELNLYKIAKLQTMNYIA--------LVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVS 241

  Fly   245 KESQRGRKRVTRLVVVVVIAFASLWLPVQLI----LLLKSLDVIETNTLTKLVIQVTAQTLAYSS 305
            .     ||.:|.:::.::|.|. .:||...:    |....:.:.:......|||.:   .||.::
Human   242 H-----RKALTTIIITLIIFFL-CFLPYHTLRTVHLTTWKVGLCKDRLHKALVITL---ALAAAN 297

  Fly   306 SCINPLLYAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSC 349
            :|.|||||.|..|||:.....|:.         ...|...||.|
Human   298 ACFNPLLYYFAGENFKDRLKSALR---------KGHPQKAKTKC 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	82/305 (27%)
		TM helix 1	40..66	CDD:320224	9/25 (36%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	13/29 (45%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	6/31 (19%)
		TM helix 6	249..279	CDD:320224	8/33 (24%)
		TM helix 7	292..317	CDD:320224	12/24 (50%)
CYSLTR2	NP_065110.1	7tmA_CysLTR2	39..316	CDD:320285	84/321 (26%)
		TM helix 1	39..66	CDD:320285	11/42 (26%)
		TM helix 2	73..98	CDD:320285	11/29 (38%)
		TM helix 3	111..141	CDD:320285	13/29 (45%)
		TM helix 4	153..175	CDD:320285	4/28 (14%)
		TM helix 5	198..227	CDD:320285	6/36 (17%)
		TM helix 6	240..270	CDD:320285	8/35 (23%)
		TM helix 7	284..309	CDD:320285	12/27 (44%)