Protein Alignment AstA-R2 and hcrtr2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001073337.1
• Gene: hcrtr2 / 561260
• ZFINID: ZDB-GENE-070228-3
• Length: 424
• Species: Danio rerio
• Alignment Length: 369
• Identity: 99/369 - (26%)
• Similarity: 175/369 - (47%)
• Gaps: 65/369 - (17%)

  Fly    29 EWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIP 93
            ||:.|.|   :|:.|...::      ||.||...|..|::||:.||..||||:.||::..|.|:|
Zfish    54 EWVLIAG---YILVFLVSLV------GNTLVCFAVWKNHHMRTVTNYFIVNLSFADILVTITCLP 109

  Fly    94 FTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIA 158
            .:....:...|.:|:..|:.:.||..::...|:.||..::.||:.|:.||::.:  .|......:
Zfish   110 ASLVVDITETWFFGQTLCKILPYLQTISVSVSVLTLSCIAQDRWYAICHPLKFK--STAKRARKS 172

  Fly   159 IVTLWIVVLVVSVPVAFTHDVVVDYDA------KKNITYGMCTFTTNDFLGPRTYQVTFFISSYL 217
            ||.:|:|..::.:|.|    ||::..:      .|...:.:|.....|.:.|:.|...|||.:|.
Zfish   173 IVLIWLVSCIMMIPQA----VVMESSSLMPELTNKTSLFTVCDEQWPDEIYPKVYHTCFFIVTYF 233

  Fly   218 LPLMIISGLYMRMIMRLWRQ-----------------------GTG----VRMSKESQ-----RG 250
            .||.::...|:::..:||.|                       |:|    ||.|..|.     :.
Zfish   234 APLCLMVLAYIQICHKLWCQQIPGSSSVLQRQWKSLQCSAHAVGSGESVKVRTSTVSAEAKQVKA 298

  Fly   251 RKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQ---VTAQTLAYSSSCINPLL 312
            |::..|:::||:..||..:||:.::.::|.:.....||..:..:.   ..:..|.|::|..||::
Zfish   299 RRKTARMLMVVLFVFALCYLPISILNIMKRVFGAFKNTGNRETVYAWFTFSHWLIYANSAANPII 363

  Fly   313 YAFLSENFRKAFYKA--VNCSSRYQNYTSDLPPPRKTSCARTST 354
            |.|||..||:.|..|  ..||.|.:.:       ::.:..||||
Zfish   364 YNFLSGKFREEFKAAFICQCSGRGETH-------KQRARGRTST 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	86/325 (26%)
		TM helix 1	40..66	CDD:320224	7/25 (28%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	9/29 (31%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	9/28 (32%)
		TM helix 6	249..279	CDD:320224	8/29 (28%)
		TM helix 7	292..317	CDD:320224	7/27 (26%)
hcrtr2	NP_001073337.1	7tmA_OXR	55..375	CDD:320336	89/334 (27%)
		TM helix 1	56..82	CDD:320336	9/34 (26%)
		TM helix 2	89..115	CDD:320336	11/25 (44%)
		TM helix 3	127..157	CDD:320336	9/29 (31%)
		TM helix 4	168..189	CDD:320336	6/24 (25%)
		TM helix 5	220..249	CDD:320336	9/28 (32%)
		TM helix 6	297..327	CDD:320336	8/29 (28%)
		TM helix 7	343..368	CDD:320336	7/24 (29%)
		Orexin_rec2	390..>424	CDD:427531	4/18 (22%)