DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and GPR84

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_065103.1	Gene:	GPR84 / 53831	HGNCID:	4535	Length:	396	Species:	Homo sapiens

Alignment Length:	380	Identity:	82/380 - (21%)
Similarity:	141/380 - (37%)	Gaps:	129/380 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWC 111
            |:|:||..||:|.:|.:.....:|:..||:|.||..|||::..|..||:...|:..:|..|..:|
Human    29 VVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFC 93

  Fly   112 RSVQYLIVVTAFASIYTLVLMSIDRFLAVVHP-IRSRMMRTENITLIAIVTLWIV---------V 166
            |....|:..:...||.||.|:::.|:|.:.|| :..::...:.|.| |:|:.|:|         .
Human    94 RVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL-ALVSTWVVGVASFAPLWP 157

  Fly   167 LVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIIS------- 224
            :.:.|||..|                 |:|   |.:..|.|........::|.|..:.
Human   158 IYILVPVVCT-----------------CSF---DRIRGRPYTTILMGIYFVLGLSSVGIFYCLIH 202

  Fly   225 ---------------------------------GLYMRMIMRLWRQGTGVRMSKE---------- 246
                                             |.:..:..||...|....:|.|
Human   203 RQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTL 267

  Fly   247 ------------SQRGRK------------------------------RVTRLVVVVVIAFASLW 269
                        |:|.::                              :|||:...|.:.||..:
Human   268 EGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSY 332

  Fly   270 LPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAF 324
            :|..|      |::::.......|:.:.|..|.:.:.||||:|||.::..||:|:
Human   333 IPFLL------LNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAY 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	39/117 (33%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	72/359 (20%)
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	81/378 (21%)
		TM helix 1	22..48	CDD:320338	8/18 (44%)
		TM helix 2	55..78	CDD:320338	11/22 (50%)
		TM helix 3	93..123	CDD:320338	10/29 (34%)
		TM helix 4	137..155	CDD:320338	6/18 (33%)
		TM helix 5	175..200	CDD:320338	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..311		7/66 (11%)
		TM helix 6	312..342	CDD:320338	9/35 (26%)
		TM helix 7	349..374	CDD:320338	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100