Protein Alignment AstA-R2 and RXFP3

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_057652.1
• Gene: RXFP3 / 51289
• HGNCID: 24883
• Length: 469
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 90/326 - (27%)
• Similarity: 148/326 - (45%)
• Gaps: 51/326 - (15%)

  Fly    40 IVGFFFGVIAITGFFGNLLVILVVVFNNNMR-STTNLMIVNLAAADLMFVILCIPFTATDYMV-Y 102
            ::...:.|:...|..|||||:.::......| |:.||.:.|||..|..|| |.:||.|.:..: :
Human    83 LISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFV-LTLPFWAVENALDF 146

  Fly   103 YWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTEN-------------- 153
            .||:|:..|:.|..:..:..:||::.|..||:.|:.:|...::|...|...
Human   147 KWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCC 211

  Fly   154 ITLIAI-VTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSY- 216
            .:..|: |.:|.:..:.|:|.|.....|      |.:...:|.....|.|..|..|  |::..|
Human   212 FSAKALCVWIWALAALASLPSAIFSTTV------KVMGEELCLVRFPDKLLGRDRQ--FWLGLYH 268

  Fly   217 --------LLPLMIISGLYM---RMIMRLWRQGT-------GVRMSKESQRGRKRVTRLVVVVVI 263
                    :|||.||...|:   |.|......||       |.|.:..|.|...:||:.|.:||:
Human   269 SQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVL 333

  Fly   264 AFASLWLPVQLI----LLLK--SLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRK 322
            :|...|||.|.:    :|:|  ::...:...|.::.....:..||:|:||:||:||..:...|||
Human   334 SFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRK 398

  Fly   323 A 323
            |
Human   399 A 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	90/326 (28%)
		TM helix 1	40..66	CDD:320224	7/25 (28%)
		TM helix 2	73..99	CDD:320224	12/25 (48%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	4/34 (12%)
		TM helix 5	204..233	CDD:320224	12/40 (30%)
		TM helix 6	249..279	CDD:320224	12/33 (36%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)
RXFP3	NP_057652.1	7tmA_RNL3R1	82..400	CDD:320592	90/326 (28%)
		TM helix 1	83..109	CDD:320592	7/25 (28%)
		TM helix 2	117..142	CDD:320592	12/25 (48%)
		TM helix 3	155..185	CDD:320592	8/29 (28%)
		TM helix 4	212..232	CDD:320592	4/19 (21%)
		TM helix 5	264..289	CDD:320592	7/24 (29%)
		TM helix 6	319..349	CDD:320592	11/29 (38%)
		TM helix 7	368..393	CDD:320592	9/24 (38%)